Equivalent Graft-Versus-Host Reactivity of Spleen Cells From Two Lines of Mice Genetically Selected for High and Low Humoral Antibody Formation

Byfield, Patricia; Howard, J. G.

doi:10.1097/00007890-197207000-00023

Cited by 19 publications

(5 citation statements)

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“…Our results indicate that CMI is better developed in HL than in LL mice. However, these results seem to be in direct contradiction to other published results which did not describe any T-cell-mediated interline difference (9,10,24,34). But this might only be an apparent contradiction since the absence of interline difference was observed with nonreplicating antigens, such as those involved in skin graft rejection, and contact-sensitizing antigens.…”

Section: Discussioncontrasting

confidence: 99%

“…The HL and LL differ greatly in the cytodynamics of their B-cell responses (4) and in the macrophagic functions, namely those concerning the metabolism and presentation of the antigen to lymphocytes (39). By contrast, the T-cell-mediated immunity (CMI) exhibited by these strains is quantitatively similar with regard to graft-versus-host (9) and allograft reactions (24), phytohemagglutinin responsiveness (25), and picryl-chloride sensitization (34).…”

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confidence: 99%

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Immunological behavior after mycobacterial infection in selected lines of mice with high or low antibody responses

Lagrange¹,

Hurtrel²,

Thickstun³

1979

Infect Immun

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Resistance and susceptibility to mycobacterial infection in the Biozzi high and low lines of mice which were genetically selected for their responses to heterologous erythrocytes have been found to be related to the innate ability of nonimmune macrophages to kill or inhibit the growth of the organisms during the first two weeks after infection and to their ability to mount specific and nonspecific immune responses. High antibody-producer mice were more capable of expressing cell-mediated immune parameters than low antibody-producer mice. A direct relationship was observed between the ability of bacteria (BCG vaccine) to multiply inside the reticuloendothelial system and the development of cell-mediated immunity, as measured by the delayed local reaction at the injection site, the lymphoproliferative response in the draining nodes, the tuberculin delayed-type hypersensitivity, the acquired resistance, and the adjuvant effect after BCG inoculation. In high line mice, apart from the inability of their macrophages to inhibit the early growth of bacteria, their lymphocytes in spleen and thymus were more capable of being stimulated in vitro by varying concentrations of living BCG. The data presented in this report are compatible with the hypothesis that a group of genes segregated in each line during the selective breeding controls the innate microbicidal activity.

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Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

Immunological behavior after mycobacterial infection in selected lines of mice with high or low antibody responses

Lagrange¹,

Hurtrel²,

Thickstun³

1979

Infect Immun

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“…A series of results obtained in strains of mice genetically selected for high and low antibody responsiveness, clearly demonstrated the independent polygenic regulation between the quantitative antibody response and several T‐cell‐mediated immunities, including DTH reactions [7–10].…”

Section: Introductionmentioning

confidence: 99%

Independent Genetic Control of B‐ and T‐Cell Tolerance in Strains of Mouse Selected for Extreme Phenotypes of Oral Tolerance

et al. 2001

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Two strains of mice were genetically selected for susceptibility (TS-Ab/HetS strain) or resistance (TR-Ab/ HetS strain) to oral tolerance of the humoral response by using ovalbumin (OVA). The progressive interstrain divergence produced by bi-directional selective breeding during 15 generations demonstrated the polygenic nature of oral tolerance. This paper shows the humoral and delayed-type hypersensitivity (DTH) responses, after intragastric administration of OVA and subsequent immunization with that immunogen in complete Freund adjuvant (CFA). Only the TS-Ab/HetS mice were tolerant for immunoglobulin (Ig)G production with its tolerance degree being the same as that obtained when Al (OH) 3 was employed. The DTH reactivity was not correlated to the antibody responsiveness, because both the TS-Ab/ HetS and TR-Ab/HetS strains had their DTH reactions suppressed. The cyclophosphamide (Cy) pretreatment prevented DTH suppression on TR-Ab/HetS but do not in TS-Ab/HetS mice. Interstrain difference was also observed for the splenic index in the Cy-treated groups, although the number of splenocytes was the same. Flux cytometry cell analysis showed the recovery of CD3 1 cell numbers in both strains, but only the TR-Ab/HetS mice had their CD4/CD8 pattern restored. These results suggest: firstly, the independent control of DTH and humoral tolerance responsiveness; secondly no support for the clonal anergy concept; and thirdly the matrix proteins neo-synthesis after Cy treatment may facilitate the tolerance abrogation.

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“…H and L lines, which differ widely in their antibody response to most antigens, do not differ significantly in their ability to mount T cell-mediated responses such as skin graft rejection [7], graftvs. -host reaction [9], delayed-type hypersensitivity [ 101 and mitotic response to phytohemagglutinin [ll].…”

Section: Introductionmentioning

confidence: 99%

Defective antigen presentation by macrophages from mice genetically selected for low antibody response

Adorini

Doria

1981

Eur J Immunol

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Rome Mice, selected for high (H) and low (L) antibody responses to xenogeneic erythrocytes (Biozzi mice, selection I), have been tested for their immune responsiveness to lysozymes. The anti-ring-necked pheasant egg-white lysozyme (REL) and anti-hen egg-white lysozyme (HEL) primary plaque-forming cell responses are 20 to 40-fold lower in L than in H mice. The heterogeneity of anti-HEL antibodies in the secondary response, as analyzed by isoelectric focusing, is highly reduced in L as compared to H mice. The in vitro anti-HEL plaque-forming cell secondary response of (H X L)Fl lymph node (LN) cells is induced by HEL-pulsed macrophages (M@) from H, but not from L, mice. Therefore, genetic differences affecting antibody responsiveness in H and L mice are expressed at the level of antigen-presenting cells. This genetic defect observed in L cells has been studied in more detail using an antigen-specific, T celldependent LN cell proliferative assay. After HEL-complete Freund's adjuvant (CFA) priming, LN cells from H or (H X L)Fl mice respond to HEL, REL (which is cross-reactive with HEL) and purified protein derivative of tuberculin (PPD), whereas LN cells from L mice do not respond to HEL or REL but proliferate in the presence of PPD. Proliferation of HEL-CFA primed (H X L)F1 LN cells is induced by HEL-or REL-pulsed M@ from H but not from L mice, whereas PPD-pulsed M@ from H or L mice give similar proliferative responses. By increasing %-fold the concentration of HEL used to pulse M@ from H and L mice, a comparable proliferative response is obtained when HEL-CFA-primed (H X L)Fl LN cells are stimulated with HEL-pulsed M@ from either line. This finding indicates that the genetic defect at the antigen-presenting cell level in L mice is not absolute, but rather reflects a different antigen handling by M@ in the two lines.

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Equivalent Graft-Versus-Host Reactivity of Spleen Cells From Two Lines of Mice Genetically Selected for High and Low Humoral Antibody Formation

Cited by 19 publications

References 0 publications

Immunological behavior after mycobacterial infection in selected lines of mice with high or low antibody responses

Immunological behavior after mycobacterial infection in selected lines of mice with high or low antibody responses

Independent Genetic Control of B‐ and T‐Cell Tolerance in Strains of Mouse Selected for Extreme Phenotypes of Oral Tolerance

Defective antigen presentation by macrophages from mice genetically selected for low antibody response

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