Eradication and reinfection of human papillomavirus after photodynamic therapy for cervical intraepithelial neoplasia

Ichimura, Hajime; Yamaguchi, Satoshi; Kojima, Atsumi; Tanaka, Tatsuya; Niiya, Kiyoshi; Takemori, Masayuki; Hasegawa, Kazuo; Nishimura, Ryuichiro

doi:10.1007/s10147-003-0354-4

Cited by 49 publications

(19 citation statements)

References 11 publications

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“…They occur on the male or female external genitalia, around the anus, and in women HPV infects the uterine cervix where (if the virus is type 16 or 17) it can lead to development of cervical intraepithelial neoplasia (CIN) and cervical cancer. Ichimura et al showed PDT (with a 630-nm YAG-OPO laser after 60 h of polyhematoporphyrin ether/ester 2 mg/kg IV) was effective not only in improving the cytological and histological measures when treating CIN but also for eradicating cervical HPV (115). …”

Section: Pdt For Clinical Infectious Diseasementioning

confidence: 99%

Photodynamic therapy for localized infections—State of the art

Dai

Huang

Hamblin

2009

Photodiagnosis and Photodynamic Therapy

677

494

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Photodynamic therapy (PDT) was discovered over one hundred years ago by observing the killing of microorganisms when harmless dyes and visible light were combined in vitro. Since then it has primarily been developed as a treatment for cancer, ophthalmologic disorders and in dermatology. However in recent years interest in the antimicrobial effects of PDT has revived and it has been proposed as a therapy for a large variety of localized infections. This revival of interest has largely been driven by the inexorable increase in drug resistance amongst many classes of pathogen. Advantages of PDT include equal killing effectiveness regardless of antibiotic resistance, and a lack of induction of PDT resistance. Disadvantages include the cessation of the antimicrobial effect when the light is turned off, and less than perfect selectivity for microbial cells over host tissue. This review will cover the use of PDT to kill or inactivate pathogens in ex vivo tissues and in biological materials such as blood. PDT has been successfully used to kill pathogens and even to save life in several animal models of localized infections such as surface wounds, burns, oral sites, abscesses and the middle ear. A large number of clinical studies of PDT for viral papillomatosis lesions and for acne refer to its anti-microbial effect, but it is unclear how important this microbial killing is to the overall therapeutic outcome. PDT for periodontitis is a rapidly growing clinical application and other dental applications are under investigation. PDT is being clinically studied for other dermatological infections such as leishmaniasis and mycobacteria. Antimicrobial PDT will become more important in the future as antibiotic resistance is only expected to continue to increase.

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Section: Pdt For Clinical Infectious Diseasementioning

confidence: 99%

Photodynamic therapy for localized infections—State of the art

Dai

Huang

Hamblin

2009

Photodiagnosis and Photodynamic Therapy

677

494

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“…In this study we expand on our preliminary report of the therapeutic effect of PDT in 31 CIN cases which suggested that PDT is effective for treating cervical dysplasia, and for the eradication of cervical HPV [12]. We now describe the effectiveness PDT in 105 cases, of CIN with a median follow-up period of 636 days.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy for Cervical Intraepithelial Neoplasia

Yamaguchi¹,

Tsuda²,

Takemori³

et al. 2005

Oncology

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Objectives: Photodynamic therapy (PDT) is a minimally invasive treatment for cervical intraepithelial neoplasia (CIN). We report the effectiveness of PDT in 105 cases of CIN. Methods: All patients received photofrin (PHE) 2 mg/kg intravenously and, 48–60 h later, phototherapy was performed using the Excimer dye laser or a YAG-OPO laser with an irradiation dose of 100 J/cm² using 630 nm wavelength. Results: Mild photosensitivity occurred in 48% (50/105) of patients. The complete response (CR) rate was 90% (94/105) at 3 months following treatment. In the remaining 11 patients, 5 patients had CIN1, 2 patients had CIN2, and 4 patients had mild cytologic findings. However, in 9 of these 11 patients, CR was achieved 6 months after PDT. In 69 patients, human papilloma virus (HPV) typing was performed before and after PDT therapy. Pre-treatment, 64 of 69 patients (93%), were HPV-positive including 30 cases of high-risk HPV (43%). Testing performed 3, 6 and 12 months following PDT revealed no HPV-DNA in 75% (52/69), 74% (48/65) and 72% (41/57) of patients. At present, the median follow-up period is 636 days (90–2,232 days). In 3 patients, recurrence requiring surgical treatment was identified at 646, 717 and 895 days after PDT. Conclusions: PDT is an effective and minimally invasive treatment for CIN, which also appears to eradicate HPV infection.

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“…Ces derniers entraînant la lyse cellulaire. Plusieurs études ont démontré l'avantage de la thérapie photodynamique (PDT) dans le traitement des SIL réduisant le risque de saignement après conisation, et améliorant les résultats à long terme diminuant les sténoses cervicales et les menaces d'accouchement prématuré [22,[25][26][27][28][29][30]. Les techniques de PDD et de PDT sont prometteuses mais toujours en cours d'expérimentation en gynécologie.…”

Section: Discussionunclassified