Eradication Effect of Javanese Turmeric (Curcuma Xanthorrhiza. Roxb.) Extract on the Early Phase of Candida Albicans Biofilm

Puspitawati, Ria; Lewiyonah, Rista; Herdiantoputri, Ranny Rahaningrum; Gultom, Ferry Pergamus; Suniarti, Dewi Fatma

doi:10.22159/ijap.2017.v9s2.29

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…The MIC and MFC of Javanese turmeric ethanol extract against planktonic C. albicans in this study were 20% and 35%, respectively. This study had higher MIC and MFC values than a previous study that reported extract MIC and MFC of 10% and 20%, respectively [6]. This difference could be due to the different xanthorrhizol content in the Javanese turmeric extracts used in the studies.…”

Section: Discussioncontrasting

confidence: 61%

“…during the proliferation phase (3 hours) [6]. From these two studies, we can see that the more mature the C. albicans biofilm, the higher the extract concentration required to eradicate the biofilm and the weaker the extract's eradication effect.…”

Section: Discussionmentioning

confidence: 91%

“…It was previously reported that xanthorrhizol, which is isolated from Javanese turmeric root, had an antifungal effect in inhibiting C. albicans biofilm with a minimum inhibitory concentration (MIC) of 1-5 mg/L and a minimum fungicidal concentration (MFC) of 5-10 mg/L [4,5]. Javanese turmeric ethanol extract had been reported to eradicate the early phase of C. albicans biofilm [6]. An agent's antifungal effect in penetrating and disrupting the development and morphology of the biofilm is known as its eradication effect [7].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that Javanese turmeric ethanol extract has an antifungal effect against planktonic C. albicans and could eradicate C. albicans biofilm in the initial phase [4,6]. The aim of this study was to investigate the potency of Javanese turmeric ethanol extract in inhibiting and eradicating the mature phase of C. albicans biofilm.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition and Eradication Effect of Javanese turmeric (Curcuma xanthorrhiza Roxb.) Extract Against Mature Phase Biofilm of Candida albicans

Puspitawati

Maira

Suniarti

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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Objective: To analyze the potency of Javanese turmeric extract in inhibiting and eradicating the mature phase of C. albicans biofilm. Material and Methods: C. albicans ATCC 10231 was cultured in Sabouraud Dextrose Broth on a 96-well plate and was incubated at 37ºC. To analyze its inhibitory effect, C. albicans cultures were incubated for 1.5 hours before being exposed to various concentrations of Javanese turmeric extract, followed by a further 48-hour incubation to reach the maturation phase. To analyze the eradication effect, the 48-hour C. albicans cultures were exposed to the extract and incubated further for 24 hours. Nystatin (100,000 IU) was used as a positive control. The percentage of viable C. albicans cells on the 48-hour biofilm was determined by a methylthiazol tetrazolium assay. This value was converted into the percentage of the extract's minimum inhibitory and eradication concentrations. Results: Against the mature phase C. albicans biofilm, the minimum biofilm inhibitory concentration of the Javanese turmeric extract was 40%, while the minimum biofilm eradication concentration was 45%. There were significant differences between the inhibition percentage of the positive control and that of the solutions exposed to Javanese turmeric with all the tested concentrations (p<0.05). There was a strong positive correlation between the increase in extract concentration and the eradication percentage of the mature C. albicans biofilm (r=0.981). Conclusion: Javanese turmeric extract is potential for inhibiting and eradicating mature phase C. albicans biofilm. The extract is more effective in inhibiting than in eradicating the biofilm.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inhibition and Eradication Effect of Javanese turmeric (Curcuma xanthorrhiza Roxb.) Extract Against Mature Phase Biofilm of Candida albicans

Puspitawati

Maira

Suniarti

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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“…Medicinal plant's extract from Acacia arabica, Tamarix aphylla L., and Melia azadirachta L. showed evidence of reducing oral biofilm formation and cleaning the well-developed oral biofilm [45]. Medicinal plant from South East Asia, C. xanthorrhiza Roxb., has also been proven through several studies to have eradication and inhibition effects against oral bacteria and candida biofilm [23,[46][47][48][49][50][51][52][53].…”

Section: Current Treatment and Challenges Using Chx And Other Antibac...mentioning

confidence: 99%

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Suniarti¹,

Puspitawati²,

Yanuar³

et al. 2022

Focus on Bacterial Biofilms

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Most common oral diseases are directly related to oral biofilm, a complex community of microorganisms inhibiting the oral cavity. Recent studies provide deeper knowledge on how free-floating bacteria form a structurally organized microecosystem and on its pathogenicity and its self-defense mechanisms; thus, creating an understanding of the challenges in eliminating oral biofilm and maintaining the balance of oral ecosystem. Chlorhexidine has been the standard oral antimicrobial agent for decades. However, studies showed that it is less effective against bacteria in the form of biofilm that leads to an ongoing search of another method to fight against biofilm, including the use of plant-derived compounds. Medicinal plants are known to contain secondary metabolites, which are not only important in protecting the plant from any harmful environment but also potential as antimicroorganism and antioral biofilm for humans. Curcuma xanthorrhiza Roxb., containing xanthorrhizol (XNT), an essential bioactive compound, is an Indonesian native medicinal plant proven to have antibacterial and antibiofilm activities by several in vitro studies. The understanding of biofilm formation, its resistance to common drugs, and the potential role of C. xanthorrhiza-derived compounds as antibacterial and antibiofilm may contribute to developing C. xanthorrhiza into the alternative weapon against oral biofilm-related diseases.

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Fractionation of bioactive materials temulawak rhizome (Curcuma xanthorrhiza) on fungal Candida albicans in search of phytopharmaca

Novianti

Kartika

2019

J. Phys.: Conf. Ser.

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Candida albicans fungus is a microbiota in the human body that is opportunistic. In general, infections caused by C. albicans are called candidiasis. Some studies have shown that C. albicans is resistant to antifungal agents, so an alternative antifungal medication is needed at affordable and safe prices. One alternative is to increase the use of medicinal herbs. The purpose of the research was to study the possibility of utilizing the Temulawak rhizome as a phytopharmaca material to treat candidiasis disease by C. albicans infection. The specific objective is to isolate the bioactive material and to determine the class of antifungal active fraction of Temulawak rhizome against C. albicans. Isolation of temulawak rhizome by way of extracted by stratified using soxhlet, then done fractionation using the method of vacuum chromatography, then bioautographic test using thin plate chromatography. Testing of bioactive fraction temulawak rhizome using thin plate chromatography obtained purple color indicating the class of terpenoids compounds and yellow color indicating the class of phenols compounds. The fraction of methanol extract from Temulawak rhizome makes it possible to be used as raw material of phytopharmaca because it has antifungal effectiveness against C. albicans.

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Eradication Effect of Javanese Turmeric (Curcuma Xanthorrhiza. Roxb.) Extract on the Early Phase of Candida Albicans Biofilm

Cited by 4 publications

References 11 publications

Inhibition and Eradication Effect of Javanese turmeric (Curcuma xanthorrhiza Roxb.) Extract Against Mature Phase Biofilm of Candida albicans

Inhibition and Eradication Effect of Javanese turmeric (Curcuma xanthorrhiza Roxb.) Extract Against Mature Phase Biofilm of Candida albicans

Curcuma Xanthorrhiza Roxb. An Indonesia Native Medicinal Plant with Potential Antioral Biofilm Effect

Fractionation of bioactive materials temulawak rhizome (Curcuma xanthorrhiza) on fungal Candida albicans in search of phytopharmaca

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