Eradication of C. albicans and T. rubrum with photoactivated indocyanine green, Citrus aurantifolia essential oil and fluconazole

Fekrazad, Reza; Mir, Arash Poorsattar Bejeh; Barghi, Vadood Ghasemi; Shams-Ghahfarokhi, Masoomeh

doi:10.1016/j.pdpdt.2014.12.009

Cited by 19 publications

(9 citation statements)

References 34 publications

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“…According to the World Health Organization (WHO), resistant microorganisms (including bacteria, fungi, viruses, and parasites) can withstand attack by antimicrobial drugs, so standard treatments can become ineffective and infections persist, increasing the risk of spread to other microbes, resulting in resistance. 57 The 2014 WHO report on global surveillance of antimicrobial resistance revealed that antimicrobial resistance, including antifungal resistance, is no longer a prediction for the future, as it is occurring worldwide now and is increasing the risk of being unable to properly treat common infections in the community and hospitals. For this reason, fostering innovative research and developing new vaccines, diagnostics, infection treatment options, and other tools is urgently needed.…”

Section: Discussionmentioning

confidence: 99%

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Caneschi

Almeida

Martins

et al. 2017

Brazilian Journal of Microbiology

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Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a–4f) and p-hydroxybenzoic acid (9a–9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series 4b–4e, mainly 4c and 4e compounds, were effective against filamentous fungi and yeast (MIC from 7.8 to 312 μg/mL). On the other hand, the amide series (9a–9f) did not present inhibitory effect against fungi, except amide 9c, which demonstrated activity only against C. albicans. This allowed us to infer that the presence of amine group and intermediate carbon number (8C–11C) in its aliphatic side chain seems to be important for antifungal activity. Although these compounds present cytotoxic activity on macrophages J774, our results suggest that these aromatic compounds might constitute potential as leader molecules in the development of more effective and less toxic analogs that could have considerable implications for future therapies of onychomycosis.

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Section: Discussionmentioning

confidence: 99%

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Caneschi

Almeida

Martins

et al. 2017

Brazilian Journal of Microbiology

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“…According to Arias et al (2005) Citrus aurantifolia possess an array of biologically active ingredients namely β-pinene, limonene, γ-terpinene, terpinolene, α-terpineol and citral responsible for its antimicrobial activity, in particular on Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis). According to a recent study conducted by Fekrazad et al (2015), photoactivated Citrus aurantifolia essential oil lead to considerable eradication of Candida albicans which could be beneficial for individuals having a high risk of Candida infections due to diabetes mellitus and other health complications.…”

Section: Use Value (Uv)mentioning

confidence: 99%

Ethnopharmacological analysis of medicinal plants used against non-communicable diseases in Rodrigues Island, Indian Ocean

Samoisy

Mahomoodally

2015

Journal of Ethnopharmacology

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“…In recent years, the incidence of fungal infections especially Candida -related disorders termed generally as “candidiasis” has increased dramatically in many countries [ 8 ]. On the other hand, it is known that disseminated infections with C. albicans cause significant morbidity and mortality among immunocompromised individuals, such as Human Immunodeficiency Virus (HIV) patients, transplant recipients, and cancer patients [ 8 , 9 , 10 , 11 ]. Furthermore, progression of the yeast with increasing the resistance of therapeutic conventional medicine increased the need for the most effective treatment [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and γ-Terpinene—An In Vitro Study

et al. 2017

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The candidiasis caused by C. albicans is a public health problem. The abuse of antifungals has contributed to the development of resistance. B. morelensis has demonstrated antibacterial and antifungal activities. In this work the activity of the essential oil of B. morelensis was evaluated and for its two pure compounds with analysis of the different mechanisms of pathogenesis important for C. albicans. The essential oil was obtained by the hydro-distillation method and analyzed using GC–MS. The anti-Candida activity was compared between to essential oil, α-Pinene and γ-Terpinene. GC–MS of the essential oil demonstrated the presence of 13 compounds. The essential oil showed antifungal activity against four C. albicans strains. The most sensitive strain was C. albicans 14065 (MFC 2.0 mg/mL and MIC50 0.125 mg/mL) with α-Pinene and γ-Terpinene having MFCs of 4.0 and 16.0 mg/mL respectively. The essential oil inhibited the growth of the germ tube in 87.94% (8.0 mg/mL). Furthermore, it was observed that the essential oil diminishes the transcription of the gene INT1. This work provides evidence that confirms the anti-Candida activity of the B. morelensis essential oil and its effect on the growth of the germ tube and transcription of the gene INT1.

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Eradication of C. albicans and T. rubrum with photoactivated indocyanine green, Citrus aurantifolia essential oil and fluconazole

Cited by 19 publications

References 34 publications

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Ethnopharmacological analysis of medicinal plants used against non-communicable diseases in Rodrigues Island, Indian Ocean

Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and γ-Terpinene—An In Vitro Study

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