Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine

Liu, Zhian; Fusi, Alberto; Schmittel, Alexander; Tinhofer, Ingeborg; Schneider, Achim; Keilholz, Ulrich

doi:10.4161/cbt.10.9.13323

Cited by 25 publications

(15 citation statements)

References 20 publications

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“…12 Expression of EGFR in CTCs of patients with breast cancer may predict response to lapatinibbased treatments. 21 Traditional tumor markers used for diagnosis and to monitor the disease process of pancreatic cancer are limited. 22 Currently, CA19-9 is the most important biomarker for the diagnosis of pancreatic cancer.…”

Section: Resultsmentioning

confidence: 99%

Detection of apoptotic circulating tumor cells in advanced pancreatic cancer following 5-fluorouracil chemotherapy

Ren

Han

Zhang³

et al. 2011

Cancer Biology & Therapy

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Section: Resultsmentioning

confidence: 99%

Detection of apoptotic circulating tumor cells in advanced pancreatic cancer following 5-fluorouracil chemotherapy

Ren

Han

Zhang³

et al. 2011

Cancer Biology & Therapy

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“…Recently, real-time CTCs genotyping during treatment with EGFR-targeted therapies against non-small cell lung cancer [136] and breast cancer [144] has been reported. Thus, it seems that treatment decisions may be based on the molecular profile of CTCs.…”

Section: Ctcs and Metastasismentioning

confidence: 99%

Epithelial-Mesenchymal Transition: A Hallmark in Metastasis Formation Linking Circulating Tumor Cells and Cancer Stem Cells

2012

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The occurrence of either regional or distant metastases is an indicator of poor prognosis for cancer patients. The mechanism of their formation has not yet been fully uncovered, which limits the possibility of developing new therapeutic strategies. Nevertheless, the discovery of circulating tumor cells (CTCs), which are responsible for tumor dissemination, and cancer stem cells (CSCs), required for tumor growth maintenance, shed light on the metastatic cascade. It seems that CTCs and CSCs are not necessarily separate populations of cancer cells, as CTCs generated in the process of epithelial-mesenchymal transition (EMT) can bear features characteristic of CSCs. This article describes the mechanisms of CTC and CSC formation and characterizes their molecular hallmarks. Moreover, we present different types of EMT occurring in physiological and pathological conditions, and we demonstrate its crucial role in providing CTCs with a CSC phenotype. The article delineates molecular changes acquired by cancer cells undergoing EMT that facilitate metastasis formation. Deeper understanding of those processes is of fundamental importance for the development of new strategies of early cancer detection and effective cancer treatment approaches that will be translated into clinical practice.

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“…13,15 Expression of EGFR in CTCs of patients with breast cancer may predict response to lapatinibbased treatments. 16 However, there are few studies reporting the clinical relevance of malignant CTCs in ESCC. …”

Section: Discussionmentioning

confidence: 99%

Malignant characteristics of circulating tumor cells and corresponding primary tumor in a patient with esophageal squamous cell carcinoma before and after surgery

Ren¹,

He²,

Zhang³

et al. 2011

Cancer Biology & Therapy

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Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine

Cited by 25 publications

References 20 publications

Detection of apoptotic circulating tumor cells in advanced pancreatic cancer following 5-fluorouracil chemotherapy

Detection of apoptotic circulating tumor cells in advanced pancreatic cancer following 5-fluorouracil chemotherapy

Epithelial-Mesenchymal Transition: A Hallmark in Metastasis Formation Linking Circulating Tumor Cells and Cancer Stem Cells

Malignant characteristics of circulating tumor cells and corresponding primary tumor in a patient with esophageal squamous cell carcinoma before and after surgery

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