Eradication of gastric cancer is now both possible and practical

Shiotani, Akiko; Cen, Putao; Graham, David Y.

doi:10.1016/j.semcancer.2013.07.004

Cited by 101 publications

(98 citation statements)

References 74 publications

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“…It is now recognized that H. pylori causes at least 95% of all gastric cancers [63]. The lifetime risk of gastric cancer varies among populations, with a high prevalence of gastric cancer ranging from 1 to approximately 20%.…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori -induced chronic inflammation and oxidative stress create an environment conducive to DNA damage and tissue injury [13,62,63]. DNA damage leads to genetic instability and eventually neoplastic transformation.…”

Section: Virulence Potential Of the Bacteriummentioning

confidence: 99%

“…3 Mechanisms of H. pylori infection-associated genomic instabilities. Adapted from [63], with permission. AID = Activation-induced cytidine deaminase. …”

Section: Virulence Potential Of the Bacteriummentioning

confidence: 99%

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An Update on Helicobacter pylori as the Cause of Gastric Cancer

Zhang

Lü

Graham

2014

Gastrointest Tumors

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Background: Gastric cancer is the second most common cause of cancer deaths worldwide. The vast majority of gastric cancers are inflammation-related cancers caused by infection with Helicobacter pylori. H. pylori-induced oxidative stress damages DNA, resulting in genetic instability. In addition, H. pylori itself can cause DNA damage and epigenetic changes that trigger genetic instability and neoplastic transformation. Summary:H. pylori strain-specific components act in combination with host factors and environmental and dietary factors to greatly enhance the inflammatory response and thus the cancer risk. Variations in several key factors, such as the cag pathogenicity island and the VacA protein, can trigger a greater inflammatory response in host cells. Genetic polymorphisms in the host such as in the IL-1β gene, and chromosomes 9p21.3 and 10q23 also play a contributing role. Finally, diet is a major external factor that modulates the risk of gastric cancer. Key Message: The majority of gastric cancers are inflammation-related cancers caused by infection with H. pylori. Eradication of H. pylori is important for the prevention and treatment of gastric cancer. Practical Implications:H. pylori eradication results in healing of gastritis and prevention of further H. pylori-induced genetic damage. Eradication of H. pylori prior to development of atrophic gastritis can prevent the development of gastric cancer. Japan has undertaken a nationwide program to identify and eliminate H. pylori, along with surveillance for those who underwent H. pylori eradication too late to eliminate cancer risk. Population-wide eradication of H. pylori will result in gastric cancer becoming a vanishingly rare disease.

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Section: Discussionmentioning

confidence: 99%

Section: Virulence Potential Of the Bacteriummentioning

confidence: 99%

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An Update on Helicobacter pylori as the Cause of Gastric Cancer

Zhang

Lü

Graham

2014

Gastrointest Tumors

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“…Maybe patients with intestinal metaplasia and dysplasia are older than their control group. We know that if the age is increased, the chance of reducing gastric cancer may not decrease despite eradication of Helicobacter pylori [2]. So, this nonsignificant difference between patients with intestinal metaplasia and dysplasia and the control group may be due to an age difference and not merely due to these diseases themselves.…”

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confidence: 99%

Role of age in association between gastric cancer and Helicobacter pylori eradication in cases with intestinal metaplasia and dysplasia

Kabir

2015

Gastric Cancer

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“…Такая программа реализуется в Япо-нии в сочетании с последующим наблюдением за лицами с высоким риском. Продолжается разработка совершенствования рекомендаций по проведению на практике программ первич-ной и вторичной профилактики рака желудка с целью повышения их экономической эффек-тивности [4].…”

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“Serological biopsy” and screening of gastric cancer

Бордин¹,

Бяхов²,

Fedulenkova³

2015

Zlokač. opuholi

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Высокая заболеваемость и смертность от рака желудка в России определяют актуальность выработки национальной стратегии скрининга рака и пренеопластических заболеваний желудка, прежде всего атрофического гастрита. Обзор литературы демонстрирует, что наилучшим неинвазивным методом выявления лиц с высоким риском рака желудка признаны серологические тесты для диагностики H. pylori и маркеров атрофии пепсиногенов. Эрадикация H. pylori является наиболее перспективной стратегией снижения заболеваемости раком желудка.Ключевые слова: скрининг рака желудка, атрофический гастрит, гастропанель, H. pylori, пепсиноген. Контактная информацияБордин Дмитрий Станиславович -д. м.н., зав. отделом патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта ГБУЗ «Московский клинический научно-практический центр» ДЗ г. Москвы, главный внештатный гастроэнтеролог ДЗ г. Москвы в ВАО г. Москвы,

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Eradication of gastric cancer is now both possible and practical

Cited by 101 publications

References 74 publications

An Update on <b><i>Helicobacter pylori</i></b> as the Cause of Gastric Cancer

An Update on <b><i>Helicobacter pylori</i></b> as the Cause of Gastric Cancer

Role of age in association between gastric cancer and Helicobacter pylori eradication in cases with intestinal metaplasia and dysplasia

“Serological biopsy” and screening of gastric cancer

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