Role of age in association between gastric cancer and Helicobacter pylori eradication in cases with intestinal metaplasia and dysplasia

Kabir, Ali

doi:10.1007/s10120-015-0498-8

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…[20] Four studies were excluded because of the design; 1 was a case-control study, [21] and 3 others were comments without original data. [22][23][24] Three studies were excluded because they were reviews or gave notice of an ongoing study and thus contained no new data. [25][26][27] Other studies were excluded for various reasons as shown in Figure 1.…”

Section: Study Selectionmentioning

confidence: 99%

Eradication ofHelicobacter pyloriand Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies

Doorakkers¹,

Lagergren²,

Engstrand³

et al. 2016

JNCI J Natl Cancer Inst

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Section: Study Selectionmentioning

confidence: 99%

Eradication ofHelicobacter pyloriand Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies

Doorakkers¹,

Lagergren²,

Engstrand³

et al. 2016

JNCI J Natl Cancer Inst

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“…Helicobacter pylori (H. pylori), a type of Gram-negative bacteria, colonizes the epithelial cells of gastric mucosa and continuously releases toxins and induces inflammation. Chronic uncontrollable inflammation caused by H. pylori is the first step before carcinogenesis, which then develops into atrophy, intestinal metaplasia (IM), dysplasia, and eventually cancer [5][6][7]. e various lesions caused by H. pylori, covering the gastric mucosa from benign to malignant, are collectively referred to as H. pylori-related gastric disease (HPGD).…”

Section: Introductionmentioning

confidence: 99%

The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome

Zhang

Huang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Aims. The study aims to explore the effects of the single-nucleotide polymorphism of miR-27a and its expression in Helicobacter pylori (H. pylori)-related diseases and the relationship between gastric pathology and traditional Chinese medicine (TCM). Methods. Subjects were classified into six histopathological groups and five TCM syndrome groups. All specimens underwent H. pylori detection through rapid urease test and methylene blue staining. Histopathological characteristics were observed by hematoxylin-eosin. The expression of miR-27a and its genotype were, respectively, detected by Quantitative Real-Time PCR and direct sequencing. Results. H. pylori promoted the malignant evolution of gastric mucosa and were involved in the formation of TCM syndrome. In H. pylori-positive patients, the frequency of miR-27a CT genotype at the rs895819 locus and its expression in the gastric cancer group were higher than those in other pathological groups. TCM syndrome had a close relationship with histopathological changes, and patients with spleen-qi deficiency syndrome had a higher risk of gastric cancer than other syndromes, regardless of H. pylori infection. Conclusion. The C allele at miR-27a rs895819 locus may be an oncogene in gastric cancer. High levels of miR-27a could play an important role in gastric malignant evolution, especially cancerization. There is a certain connection between TCM syndrome and pathological changes of the gastric mucosa to some extent, where patients with SQD syndrome had a higher risk of GC.

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Surveillance strategy according to age after endoscopic resection of early gastric cancer

et al. 2017

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Role of age in association between gastric cancer and Helicobacter pylori eradication in cases with intestinal metaplasia and dysplasia

Cited by 5 publications

References 2 publications

Eradication ofHelicobacter pyloriand Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies

Eradication ofHelicobacter pyloriand Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies

The Single-Nucleotide Polymorphism of miR-27a rs895819 and the Expression of miR-27a in Helicobacter pylori-Related Diseases and the Correlation with the Traditional Chinese Medicine Syndrome

Surveillance strategy according to age after endoscopic resection of early gastric cancer

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