Eradication of methicillin-resistant Staphylococcus aureus with an antiseptic soap and nasal mupirocin among colonized patients – an open uncontrolled clinical trial

Kampf, Günter; Krämer, Axel

doi:10.1186/1476-0711-3-9

Cited by 27 publications

(10 citation statements)

References 28 publications

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“…This flora mainly populates the stratum corneum and the distal portions of hair follicles and sebaceous ducts. About one‐fifth of the skin flora resides at a depth of more than 0.3 mm . In particular, surgical interventions with a high risk of SSI by the skin‐resident bacteria, such as shoulder surgery or hip replacements, are in need of complementary antiseptic measures .…”

Section: Plasma Medicinementioning

confidence: 99%

Cold Physical Plasmas in the Field of Hygiene—Relevance, Significance, and Future Applications

Krämer

Bekeschus

Matthes

et al. 2015

Plasma Processes & Polymers

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Cold physical plasmas ignited a technological spark in industry, biotechnology, and medicine. Especially the field of hygiene benefited of the plasma's exceptional activity against pathogenic microorganisms. Together with plasma-based surface functionalization, these qualities are highly relevant in a variety of processes in health care, such as the decontamination or sterilization of medical devices, food, packaging materials, waste water, or indoor air. In medicine, plasma has proven to show promising antiseptic results on skin and mucosal membranes in infection-related diseases in dermatology and dentistry. This comprehensive review will discuss the current applications of cold plasma in the fields of hygiene, and will provide a promising outlook on many applications yet to come.

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Section: Plasma Medicinementioning

confidence: 99%

Cold Physical Plasmas in the Field of Hygiene—Relevance, Significance, and Future Applications

Krämer

Bekeschus

Matthes

et al. 2015

Plasma Processes & Polymers

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“…The most common use is in antimicrobial hand soaps, but it can also be found in consumer products such as liquid dishwashing soaps, deodorants and toothpastes at concentrations ranging from 0.15 to 0.3% (Campbell & Zirwas, 2007). Triclosan may also be employed in healthcare at dosages of 1% for use in high-risk high-frequency handwashing (Kampf & Kramer, 2004). The compound features good activity against Grampositive bacteria and yeasts but is somewhat less active against Gram-negative organisms, and features limited activity against mycobacteria and dermatophytes and little activity against viruses (Regö s et al, 1979;Jones et al, 2000).…”

Section: Commentmentioning

confidence: 99%

Triclosan

2009

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The title compound [systematic name: 5-chloro-2-(2,4-dichlorophenoxy)phenol], C12H7Cl3O2, is a biologically relevant molecule with biocide activity. It crystallizes in the chiral trigonal space group P3(1) with one molecule in the asymmetric unit. As in biological adducts, the two aromatic rings are almost mutually perpendicular, with this structural feature leading to a distribution of the pendant -OH groups to maximize the formation of O-H...O hydrogen bonds. This arrangement leads to a chain of molecules running parallel to the c axis and having a C(2) graph-set motif at its core.

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“…Decolonization of MRSA in the nasal vestibule is usually successful after 7 days [209]. Burn wounds are decolonized after 5 days [210], whereas chronic wounds need to be treated with mupirocin for 14 days [211,212]. …”

Section: Basic Rules Of Antiseptic Treatment In Wound Management Basmentioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

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256

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Eradication of methicillin-resistant Staphylococcus aureus with an antiseptic soap and nasal mupirocin among colonized patients – an open uncontrolled clinical trial

Cited by 27 publications

References 28 publications

Cold Physical Plasmas in the Field of Hygiene—Relevance, Significance, and Future Applications

Cold Physical Plasmas in the Field of Hygiene—Relevance, Significance, and Future Applications

Triclosan

Consensus on Wound Antisepsis: Update 2018

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