Eradication of Subgroups A and B Lymphoid Leukosis Virus from Commercial Poultry Breeding Flocks

Dv, Zander; Rg, Raymond; Cf, McClary; Goodwin, Kathryn R.

doi:10.2307/1589066

Cited by 14 publications

(3 citation statements)

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“…Thus, bursectomy prevented the development of tumours, but virus infection persisted in chickens. To date, efforts to establish chicken flocks free of LL virus have been limited for the most part to small experimental flocks in which dams are pretested for virus shedding and infected individuals are removed (Hughes et al, 1963;Zander et al, 1975;Okazaki et al, in preparation). Since Spencer et al (1976) showed large quantities of group-specific (gs) antigen and infectious virus in albumen of freshly laid eggs, albumen testing has been used as one of the major procedures to identify infected (shedder) dams.…”

Section: Introductionmentioning

confidence: 99%

Effects of storage and heat treatment of eggs on stability and congenital transmission of avian lymphoid leukosis viruses

Fadly¹,

Okazaki²

1979

Avian Pathology

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Section: Introductionmentioning

confidence: 99%

Effects of storage and heat treatment of eggs on stability and congenital transmission of avian lymphoid leukosis viruses

Fadly¹,

Okazaki²

1979

Avian Pathology

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“…Though theoretically feasible, breeding for genetic resistance is not considered a practical approach for the control of lymphoid leukosis (LL) in commercial poultry production (19). The eradication of LL may be pursued by the elimination of all viremic and serologically positive birds from a given population (18,21) or by the selection of hens that do not excrete virus in their eggs and the use of only LL virus-free eggs to hatch the succeeding generation. The latter procedure, which has successfully been applied by Hughes et al, (7), has good prospects because the natural flow of infection is then interrupted at the stage which results in the highest incidence of clinical disease and the most extensive shedding of LL viruses into the environment (5,20).…”

Section: Introductionmentioning

confidence: 99%

The control of lymphoid leukosis in a flock White Plymouth Rock chickens

Boer¹,

Vloten²,

Groenendal³

et al. 1979

Veterinary Quarterly

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Summary Lymphoid leukosis (LL) was successfully controlled in a commercial basic breeding line of White Plymouth Rock chickens. The control method has been developed for breeder flocks and consists of three elements: - In the flock under study, homogenates of embryos from all eggs collected during a number of I4-day periods are tested for the presence of LL viruses. - Only eggs from hens that have been shown not to shed virus in their eggs are used for the production of progeny. The offspring are reared in isolation during the first two months of life, at which time the age-related resistance against tumour formation by LL viruses appears to be sufficiently developed. - The chickens are subsequently inoculated intramuscularly with LL viruses of subgroups A and B transferred to a conventional chicken house. The vaccination raises a solid immunity to horizontal LL virus exposure and, due to the age-related resistance, tumour formation does not follow. No excretion of LL viruses could be detected in three generations of White Plymouth Rock chickens to which the three elements of the control procedure were applied. Clinical disease was not observed in any of the chickens under notice.

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“…Infections of chickens with avian retroviruses are widespread, as evidenced by the synthesis of specific antibodies in most chicken flocks (12,14,31). To keep flocks free from avian sarcoma and leukosis viruses, eradication methods are applied by eliminating all viremic and serologically positive birds, essentially by eliminating hens that excrete virus in their eggs (4,36). Several approaches have been used simultaneously to provide resistance to avian retrovirus infections.…”

mentioning

confidence: 99%

Immune response and resistance to Rous sarcoma virus challenge of chickens immunized with cell-associated glycoproteins provided with a recombinant avian leukosis virus

Chebloune

Rulka

Cosset

et al. 1991

J Virol

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The Rous-associated virus 1 env gene, which encodes the envelope gp85 and gp37 glycoproteins, was isolated and inserted in place of the v-erbB oncogene into an avian erythroblastosis virus-based vector, carrying the neo resistance gene substituted for the v-erbA oncogene, to generate the pNEA recombinant vector. A helper-free virus stock of the pNEA vector was produced on an avian transcomplementing cell line and used to infect primary chicken embryo fibroblasts (CEFs) or quail QT6 cells. These infected cells, selected with G418 (CEF/NEA and QT6/NEA, respectively) were found to be resistant to superinfections with subgroup A retroviruses. The CEF/NEA preparations were used as a cell-associated antigen to inoculate adult chickens by the intravenous route compared with direct inoculations of NEA recombinant helper-free viruses used as a cell-free antigen. Chickens injected with the cell-associated antigen (CEF/NEA) exhibited an immune response demonstrated by induction of high titers of neutralizing antibodies and were found to be protected against tumor production after Rous sarcoma virus A challenge. Conversely, no immune response and no protection against Rous sarcoma virus A challenge were observed in chickens directly inoculated with cell-free NEA recombinant virus or in sham-inoculated chickens.

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Eradication of Subgroups A and B Lymphoid Leukosis Virus from Commercial Poultry Breeding Flocks

Cited by 14 publications

References 0 publications

Effects of storage and heat treatment of eggs on stability and congenital transmission of avian lymphoid leukosis viruses

Effects of storage and heat treatment of eggs on stability and congenital transmission of avian lymphoid leukosis viruses

The control of lymphoid leukosis in a flock White Plymouth Rock chickens

Immune response and resistance to Rous sarcoma virus challenge of chickens immunized with cell-associated glycoproteins provided with a recombinant avian leukosis virus

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