ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes

Silva, Sabrina D.; Perez, Danyel Elias da Cruz; Alves, Fábio Abreu; Nishimoto, Inês Nobuko; Pinto, C. A.L.; Kowalski, Luiz Paulo; Graner, Edgard

doi:10.1016/j.oraloncology.2007.06.008

Cited by 30 publications

(45 citation statements)

References 40 publications

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“…18). Moreover, studies addressing the expression of ERBB2 in human preneoplastic and neoplastic oral cavity lesions have provided inconclusive and conflicting results (37)(38)(39)(40)(41)(42)(43). Whether ERBB2 is driving the early stage of carcinogenesis and at which stage this driving role acquires critical significance are not yet clearly defined.…”

Section: Discussionmentioning

confidence: 99%

A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

Berta

Sprio

Iezzi

et al. 2011

Cancer Prevention Research

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Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue, as exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here, we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size, and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents. Cancer Prev Res; 4(7); 994-1001. Ó2011 AACR.

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Section: Discussionmentioning

confidence: 99%

A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

Berta

Sprio

Iezzi

et al. 2011

Cancer Prevention Research

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“…The EGFR family includes four members: HER-1 (EGFR, ErbB1), HER-2 (neu/ErbB2), , and HER-4 (ErbB4). EGFR activation, as its name indicates, can augment the malignant potential of epithelial cells (LaCasse et al, 2008), and the overexpression correlates with poor prognosis in OSCC patients (Agra et al, 2008;Laimer et al, 2007;Silva et al, 2008Silva et al, , 2009. Cyclin proteins are key regulators of cell cycle progression.…”

Section: Cell Cycle Progression and Proliferation Biomarkersmentioning

confidence: 99%

Functional Biomarkers of Oral Cancer

Tsuda¹,

Ohba²

2012

Oral Cancer

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“…Anomalies in certain oncogenes such as ErbB1 (Her-1), ErbB2, and N-, K-and H-ras have not been found to play a key role in oral cancer (40)(41)(42)(43). When altered, genes that code for the synthesis of cyclin proteins, may act as oncogenes.…”

Section: 88 --------------------------------------------------------mentioning

confidence: 99%

Genetic and molecular alterations associated with oral squamous cell cancer (Review)

Pérez-Sayáns¹

2009

Oncol Rep

108

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Abstract. The development of oral squamous cell cancer (OSCC) is a multistep process involving the accumulation of multiple genetic alterations modulated by genetic predisposition and environmental influences such as tobacco and alcohol use, chronic inflammation, and viral infections. All of these factors can lead to a wide range of genetic and molecular alterations that can be detected using a range of molecular studies. The alterations mostly affect two large groups of genes: oncogenes and tumor suppressor genes, which can be either inactivated or overexpressed through mutations, loss of heterozygosity, deletions, or epigenetic modifications such as methylation. Other molecules that are closely associated with tumor pathogenesis and prognosis also exist and warrant further study. Important advances in molecular biology are helping to shed light on oral cancer and thus aiding in the early diagnosis and development of new personalized treatment approaches. The purpose of the review is to explore the genetic and molecular alterations associated with OSCC.

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ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes

Cited by 30 publications

References 40 publications

A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

Functional Biomarkers of Oral Cancer

Genetic and molecular alterations associated with oral squamous cell cancer (Review)

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