Erdélyi magyar egészségügyi dolgozók Magyarországra vándorlása

Pitó, Klára

doi:10.14267/phd.2016018

Cited by 1 publication

(2 citation statements)

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“…), one mechanism of action of radioprotectors which must be considered is the removal of these products of water radiolysis before they are able to react with, and damage, the critical targets whose alteration leads to cell death. The extent to which the indirect (water radiolysis) effect is important in the expression of radiation-induced cell death remains a iiotly debated topic among radiobiologists [349] cf. [12].…”

Section: A Free Radical Scavengingmentioning

confidence: 99%

“…Thiols way also participate in radical scavenging reactions, at rates which are close to the diffusion controlled limit (see §II.C.l.b.i). Even at these high rates of reaction, calculations show [349] that cysteamine (a very good scavenging thiol) would be required at a concentration of 30 mM to produce a dose reduction factor of only 1.3. Yet, cysteamine is effective to a greater degree at doses in vivo which would produce a concentration of 3 mM if the compound were distributed evenly throughout the body.…”

Section: A Free Radical Scavengingmentioning

confidence: 99%

See 1 more Smart Citation

Chemical protection against ionizing radiation. Final report

Livesey¹,

Reed²,

Adamson³

1984

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Section II reviews the contributions of various natural factors which influence the inherent radiosensitivity of biological systems. Included in the list of these factors are water, oxygen, thiols, vitamins and antioxi-«• dants. Brief attention is given to the model describing competition between oxygen and natural radioprotective substances (principally, thiols) in deter mining the net cellular radiosensitivity. Several theories of the mechanism(s) of action of radioprotective drugs are described in Section III. These mechanisms include the production of hypoxia, detoxication of radiochemical reactive species, stabilization of the radiobiological target and the enhancement of damage repair processes. Section IV describes the current strategies for the treatment of radiation injury. Likely areas in which fruitful research might be performed are described in Section V. Appendices are devoted to lists of currently-funded research projects involving chemical radiation protection and a brief compendium of compounds which have been tested for radioprotective activity.

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Section: A Free Radical Scavengingmentioning

confidence: 99%

Section: A Free Radical Scavengingmentioning

confidence: 99%