Erectile Dysfunction After External Beam Radiotherapy for Prostate Cancer

Pinkawa, Michael; Gagel, Bernd; Piroth, Marc D.; Fischedick, Karin; Asadpour, Branka; Kehl, Mareike; Klotz, Jens; Eble, Michael J.

doi:10.1016/j.eururo.2008.03.026

Cited by 87 publications

(58 citation statements)

References 25 publications

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“…The ED rates found here corroborate the findings of two prospective studies, which showed a 30-40% incidence of ED in patients between one and two years post-RT [15,16].…”

Section: Discussionsupporting

confidence: 81%

Pelvic symptoms after radiotherapy in prostate cancer: a cross-sectional study

et al. 2017

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Introduction: Despite the technical and scientific progress that improved therapeutic resources available in Oncology, adverse effects of treatment can be prominent, impacting the quality of life (QoL). Objective: This research aims to determine the prevalence of post-radiotherapy pelvic symptoms in prostate cancer (PC) and its impact on QoL. Methods: We assessed three groups of patients at different stages during radiotherapy (RT): Pre-RT, evaluated before of RT; Post-RT#1, evaluated between six months and one year post-RT; Post-RT#2, evaluated between two and a half and four years post-RT. The presence of urinary incontinence (UI), its characteristics and impact on daily living activities (DLA) were evaluated by ICIQ-SF questionnaire. WHOQOL-BREF questionnaire was used to assess QoL. Student t test was used, considering significant p < 0.05. Results: Thirty-three men were assessed (pre-RT, n = 12; Post-RT#1, n = 10; Post-RT#2, n = 11). The prevalence of lower urinary tract symptoms (LUTS) was highest in Post-RT#1 group. Post-RT#2 group had the highest * RAM: Doctoral student, e-mail: alinemrib@gmail. prevalence of post-RT UI. In QoL, Pre-RT and Post-RT#2 groups experiencing the greatest impact on physical, environmental and overall QoL. Conclusion: Acute effect of RT is characterized by a high prevalence of LUTS. Post-RT#2 group experienced the most adverse effects on DLA due to a higher prevalence of post-RT UI. n = 12; n = 10; n = 11

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“…The ED rates found here corroborate the findings of two prospective studies, which showed a 30-40% incidence of ED in patients between one and two years post-RT [15,16].…”

Section: Discussionsupporting

confidence: 81%

Pelvic symptoms after radiotherapy in prostate cancer: a cross-sectional study

et al. 2017

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“…A preference for the use of perineal, robotic, or retropubic approaches is also based on the prostate volume (11,12). Lastly, prostate volume is used for calculating the radiotherapy doses to be delivered in external beam or brachytherapy, and in planning therapies such as high-intensity focused ultrasound for prostate cancer (13,14).…”

Section: Introductionmentioning

confidence: 99%

What is the best radiological method to predict the actual weight of the prostate?

Kılıç¹,

Özdemır²,

Altinova³

et al. 2014

Turk J Med Sci

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The purpose of the present study was to investigate the composition of kidney stones removed from human patients. Seventeen samples were collected after surgery (5 females and 12 males; age range 2 to 60 years). The samples were analyzed for composition by transmission Fourier transform infrared (FT-IR) spectroscopy. The 17 analyzed samples of kidney stones comprised 29.4% calcium oxalate, 29.4% uric acid, 29.4% calcium oxalate (CaOx)-uric acid, 5.9% phosphate, and 5.9% calcium oxalate-phosphate stones. The results of the study indicated that transmission FT-IR spectroscopy could be used as an environmentally friendly technique for rapid screening of kidney stones.

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“…PDE5i might facilitate the erectile function rehabilitation process as well. It is hypothesized that PDE5i, by increasing nightly spontaneous and voluntary erections, can improve the oxygenation of the corporal bodies and therefore preserve endothelial and cavernosal function, which could result in the prevention of fibrosis after radiotherapy [13,17]. Whether and to what extent PDE5i could be effective in these much severer PCa patients is still obscure.…”

Section: Discussionmentioning

confidence: 99%

“…ED is a recognized sequela of radiotherapy for PCa, but the impact of radiotherapy on erectile function is usually underestimated, and the treatment of post-radiotherapy ED has not gained sufficient attention [4,13]. Radiotherapy purportedly induces ED by adversely affecting the ability of smooth muscle relaxation of penile arteries and corpus cavernosum, thus compromising the penis to pool blood and become turgid and erect [14].…”

Section: Discussionmentioning

confidence: 99%

Phosphodiesterase-5 Inhibitors Could Be Efficacious in the Treatment of Erectile Dysfunction after Radiotherapy for Prostate Cancer: A Systematic Review and Meta-Analysis

et al. 2012

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Objective: This systematic review was performed to evaluate the efficacy and safety of phosphodiesterase-5 inhibitors (PDE5i) in the treatment of erectile dysfunction (ED) after radiotherapy for prostate cancer (PCa). Methods: A systematic search of PubMed, Embase and the Cochrane Library was performed to identify all randomized controlled trials (RCTs). All relevant studies on the outcomes and complications of PDE5i in the treatment of ED after radiotherapy for PCa were assessed. The outcomes and complications analyzed for this study included the International Index of Erectile Function (IIEF) questionnaire, Global Efficacy Questions (GEQs), Sexual Encounter Profile (SEP) diary and side effects. The Cochrane Collaboration Review Manager software (RevMan 5.1.4) was used for statistical analysis of the outcomes and complications. Results: A total of 4 RCTs were identified from the search strategy. Compared with placebo, the trials indicated that PDE5i significantly improved the IIEF scores, with the exception of two questions (questions 6 and 13), and statistically significantly more positive answers for the GEQs and SEP diary were acquired in intervention groups. Furthermore, almost all the side effects in both groups were mild or moderate, transient and well tolerated. Except for headache, flushing and dyspepsia, all other adverse events did not differ significantly between the two groups. Conclusions: The systematic review suggested significant advantages in the efficacy and safety of PDE5i in the treatment of ED after radiotherapy for PCa. PDE5i should be considered as the first choice for the treatment of PCa patients with ED after radiotherapy.

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Erectile Dysfunction After External Beam Radiotherapy for Prostate Cancer

Cited by 87 publications

References 25 publications

Pelvic symptoms after radiotherapy in prostate cancer: a cross-sectional study

Pelvic symptoms after radiotherapy in prostate cancer: a cross-sectional study

What is the best radiological method to predict the actual weight of the prostate?

Phosphodiesterase-5 Inhibitors Could Be Efficacious in the Treatment of Erectile Dysfunction after Radiotherapy for Prostate Cancer: A Systematic Review and Meta-Analysis

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