Erectile dysfunction as a predictor of advanced vascular age

Abstract

SUMMARYVascular age (VA) represents chronological age (CA) adjusted for individual's atherosclerotic burden. The presence of erectile dysfunction (ED) has been considered as a clinical sentinel of premature atherosclerosis. The objective of this study was to explore the predictive value of ED in assessing the discrepancy between VA and CA. In the period from 1 January 2014 to 1 January 2015, all consecutive men referring to the outpatient departments of the Clinics of Urology and Cardiology in Belgrade (Serbia) were considered for enrolment in this cross-sectional study. General exclusion criteria were: age below 18, heart failure, history of myocardial infarction, impaired renal and liver function, acute infection, history of endocrine disease other than type 2 diabetes, pelvic surgery or trauma, and acute coronary syndrome within the last 6 months. According to the presence of ED, hypertension, type 2 diabetes and history of coronary artery disease participants were assigned into five study groups. Hierarchical multiple regression analysis was conducted to identify the predictive value of ED in detection of advanced VA. The mean age of males enrolled in the study was 52.9 AE 7.7 years. The predominance of VA over CA was statistically significantly higher in the group of participants with coexistence of ED and hypertension compared to the group of patients with ED and type 2 diabetes (p = 0.027) and the group of patients with ED (p = 0.014) and control group (p < 0.01). Regression analysis highlighted that ED represented a highly important marker (p < 0.01) of advanced VA, which independently accounted for 6.1% of the variance in the discrepancy between VA and CA. Our study suggests that assessment of ED could be a part of a more comprehensive prediction of patients' advanced VA. Screening among such a highly selected population may help identify those that would most benefit from drug treatments and life style changes.

Risk factors of erectile dysfunction among diabetes patients in Africa: A systematic review and meta-analysis

“…Our study suggests that assessment of ED could be a part of a more comprehensive prediction of patients' with advanced age. Also, screening among such a highly selected population may help identify those that would most benefit from pharmaceutical interventions and life-style changes [65] .…”

Sexual Dysfunction and Hypogonadism in Men With Diabetes

“…ED as a marker of potential cardiovascular (CV) events has been reported by numerous investigators (25)(26)(27)(28)(29)(30)(31)(32)(33)(34). In fact, ED has been shown to be significantly associated with all-cause mortality and CV events (35)(36)(37).…”

Relationship between the risk factors of cardiovascular disease by testing biochemical markers and young men with erectile dysfunction: a case-control study

“…It is not only strongly predictive of subsequent atherosclerotic CV events, but can also be a sentinel marker of early cardiovascular and other systemic vascular diseases. As a sentinel marker of subsequent atherosclerotic CV events, it is striking when ED presents at a younger age at a younger age (19,20). Therefore, in this study, we focused on men with ED aged 20-40 years.…”