Erectile dysfunction in patients with liver disease related to chronic hepatitis B

Abstract

Background/AimsDespite sexual function making an important contribution to the quality of life, data on erectile function are relatively scant in patients with chronic liver disease. We evaluated the prevalence of and risk factors for erectile dysfunction (ED) in patients with liver disease related to hepatitis B, especially among those with chronic hepatitis B (CHB) or early-stage cirrhosis.MethodsIn total, 69 patients (35 with CHB and 34 with hepatitis-B-related liver cirrhosis [HBV-LC]) aged 40-59 years were analyzed. Child-Pugh classes of A and B were present in 30 (88.2%) and 4 (11.8%) of the patients with HBV-LC, respectively. The erectile function of the patients was evaluated using the Korean version of IIEF-5.ResultsThe prevalence of any ED was 24.6% for all patients, and 8.6% and 41.2% for those with CHB and HBV-LC, respectively (P=0.002). While there was only one (2.9%) CHB patient for each stage of ED, mild, moderate, and severe ED stages were seen in three (8.8%), one (2.9%), and ten (29.4%) of the HBV-LC patients, respectively. Multiple regression analysis identified the type of liver disease (P=0.010), hypertension (P=0.022), score on the Beck Depression Inventory (P =0.044), and the serum albumin level (P=0.014) as significant independent factors for the presence of ED.ConclusionsThe prevalence of ED was significantly higher in patients with early-stage HBV-LC than in those with CHB. Therefore, screening male patients with early viral cirrhosis for ED and providing appropriate support are needed, especially when the cirrhosis is accompanied by hypertension, depression, or a depressed level of serum albumin.

Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension

“…Another study compared ED in alcoholics with vs without cirrhosis vs diabetics and found no difference between the groups . Only 1 study reported multivariate data in a relatively small cohort of 69 patients (34 with cirrhosis) and found cirrhosis, arterial hypertension, depression and serum albumin as significant independent factors . However, a different IIEF‐5 cut‐off than suggested in the literature was used.…”

“…With regard to aetiology, we found no difference in the distribution of ED (Table ). The prevalence of ED in alcoholic cirrhosis is described with 50%‐70% and with 40%‐92% in viral cirrhosis . In chronic hepatitis, the prevalence ranged between 9% and 78% with most studies reporting prevalence rates around 40%‐50% .…”

“…The prevalence of ED in alcoholic cirrhosis is described with 50%-70% [12][13][14] and with 40%-92% in viral cirrhosis. [14][15][16]26 In chronic hepatitis, the prevalence ranged between 9% and 78% 15,26 with most studies reporting prevalence rates around 40%-50%. 16,17,[43][44][45] Hence, it seems that once cirrhosis develops, the prevalence of ED is high irrespective of aetiology and this is also confirmed by our data.…”

Sexual Dysfunction and Sex Hormone Abnormalities in Patients With Cirrhosis: Review of Pathogenesis and Management

“…In contrast with HCV, there are fewer data regarding the prevalence of ED in hepatitis B virus (HBV). One study found an overall rate of 24.6%, but subgroup analysis revealed a higher prevalence in those with HBV and cirrhosis (41.2%) . Multivariate analysis revealed cirrhosis, hypertension, depression, and serum albumin as significant independent risk factors for ED.…”

Does Hepatitis B Affect Erectile Dysfunction and Lower Urinary Tract Symptoms?

“…Literatürde hepatit B hastalarında ED sıklığını araştıran çalışma sayısı fazla değildir. ED önemli bir hastalıktır ve kişilerin yaşam kalitesini olumsuz olarak etkileyebilmektedir (4). Alt üriner sistem yakınması (AÜSY) prevalansı da yaşlanmayla birlikte artan ve yaşam kalitesini olumsuz etkileyen önemli bir sağlık sorunudur (5).…”