Eremophilane-Type Sesquiterpenes from the Fungus <i>Xylaria</i> sp. BCC 21097

Isaka, Masahiko; Chinthanom, Panida; Boonruangprapa, Tanapong; Rungjindamai, Nattawut; Pinruan, Umpava

doi:10.1021/np100030x

Cited by 76 publications

(47 citation statements)

References 22 publications

(60 reference statements)

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“…C. lusitanica [78] Mairetolide F Xylaria sp. L. spinosa [76] Valencene M. albus C. zeylanicum [45] unidentified vine plant [79] Oryza granulata [62] Xylaria sp. C. lusitanica [78] Eudesmanes, eudesmenes (selinenes)…”

Section: Phytohormonesmentioning

confidence: 99%

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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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Section: Phytohormonesmentioning

confidence: 99%

“…[91] unnamed compounds Xylaria sp. Licuala spinosa [76] Xylaria sp. mangrove plant [92] Xylarenones Xylaria sp.…”

Section: Albusmentioning

confidence: 99%

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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“…Previous investigations have revealed that fungi of the genus Xylaria are a rich source of structurally diverse natural products. Examples include the HIV-1 integrase inhibitor integric acid [1], the cytotoxic agents xyloallenolide A [2] and eremophilanolides [3], the antifungal metabolites multiplolides A and B [4], the acetylcholinesterase inhibitors xyloketals [5], the NPY Y5 receptor antagonists xylarenals A and B [6], the chemokine receptor antagonist 19,20-epoxycytochalasin Q [7], the anti-herpes simplex virus agent mellisol [8].…”

mentioning

confidence: 99%

Terpenoid and Phenolic Metabolites from the Fungus Xylaria sp. Associated with Termite Nests

Yan

et al. 2011

Chemistry & Biodiversity

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Three new sesquiterpene acids, xylaric acids A-C (1-3, resp.), and a new tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivative, 4, along with nine known compounds, xylaric acid D (5), hydroheptelidic acid (6), gliocladic acid (7), chlorine heptelidic acid (8), trichoderonic acid A (9), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (10), 16-(α-D-glucopyranosyloxy)isopimar-7-en-19-oic acid (11), 5-carboxymellein (12), and naphthalen-1,8-diol 1-O-α-D-glucopyranoside (13) have been isolated from the solid culture of the ascomycete fungus Xylaria sp. associated with termite nest. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configurations of compounds 1-3 and 5-9 were determined by combination of X-ray data and CD spectral analysis. The absolute configuration of 4 was assigned by Snatzke's method. Compounds 8 and 11 showed slight cytotoxicities against two cell lines A549 and SGC7901.

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“…BCC 21097 associated with Licuala spinosa. The three compounds, eremophilanolide 62, 63, and 64 exhibited moderate cytotoxic activity with IC 50 values of 3.8-21 µM against cancer cell lines KB, MCF-7, and NCI-H187 (Isaka et al 2010).…”

Section: Compounds From Endophytic Fungi Of Terrestrial Plantsmentioning

confidence: 99%

Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

Deshmukh

Verekar

2014

Microbial Diversity and Biotechnology in Food Security

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This review covers substantially the cytotoxic compounds isolated from endophytic fungi from terrestrial and mangrove plants during [2009][2010][2011][2012]. Endophytes living asymptomatically within plant tissues have been found in almost all plants studied to date. Many of the compounds reported here were originally isolated from plants, then from endophytic fungi, whereas some are exclusively isolated from endophytic fungi. The anticancer activities in this review are from the published cytotoxicity against specific cancer cell lines. Development of these natural compounds is based on their cytotoxic activity profiles, chemical structures, and potential structure-activity relationship deduced from the biochemical and cytotoxic studies.

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Eremophilane-Type Sesquiterpenes from the Fungus Xylaria sp. BCC 21097

Cited by 76 publications

References 22 publications

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Terpenoid and Phenolic Metabolites from the Fungus Xylaria sp. Associated with Termite Nests

Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

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