Erfahrungen über intravenöse Fettemulsionen

Schuberth, O; Wretlind, Asger

doi:10.1007/bf02444889

Cited by 5 publications

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“…A temporary, moderate drop (about 15%) in platelet count was seen about 3 days after dosing. Similar effects have been reported with Oxyfluor , and thrombocytopenia has been documented upon administration of parenteral fat emulsions, liposomes, including Hb-loaded liposomes, and other injectable particulates. − …”

Section: Particle-related Side Effectssupporting

confidence: 60%

“…Similar effects have been reported with Oxyfluor, 406 and thrombocytopenia has been documented upon administration of parenteral fat emulsions, 1717 liposomes, 1718 including Hb-loaded liposomes, 987 and other injectable particulates. [1719][1720][1721] The mechanism of the flu-like side effects appears to be reasonably well understood. These effects are, for the most part, the natural consequence of RES clearance of particulate matter from the blood stream.…”

Section: Particle-related Side Effects a Flu-like Symptoms And Effect...mentioning

confidence: 99%

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Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

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Pharmaceutical Corporation in San Diego; however, the opinion expressed here are solely his and not necessarily those of the Corporation. Jean G. Riess received his chemical engineer and doctorat-e `s-sciences degrees (the latter with Professor Guy Ourisson in 1963) from the University of Strasbourg. He then spent two years with John Van Wazer at Monsanto in Saint-Louis, MO, learning some phosphorus and transitionmetal chemistry. In 1968 he became Professor at the University of Nice, France, where he founded, directed, and eventually became honorary director of the Unite ´de Chimie Mole ´culaire (associated with the Centre National de la Recherche Scientifique). His research successively involved phosphorus chemistry, transition-metal chemistry, organometallics, and eventually perfluorochemicals. His present interests are in fluorocarbons, fluorinated amphiphiles, and their colloid chemistry, including fluorocarbon emulsions for in vivo O 2 delivery, fluorinated self-assemblies, and drug delivery systems. Professor Riess has published about 360 papers and holds ca. 25 patents. He has served on numerous councils and committees and has chaired or co-chaired international conferences on phosphorus chemistry and blood substitutes. He has won awards from the French Academy of Sciences, French Chemical Society, Alexander von Humboldt Stifftung, City of Nice and Controlled Release Society, as well as Alliance's first Distinguished Contribution Award. He holds an honorary Research Associate position at the University of California at San Diego and sits on the Board of Directors of Alliance Pharmaceutical Corp.

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Section: Particle-related Side Effectssupporting

confidence: 60%

Section: Particle-related Side Effects a Flu-like Symptoms And Effect...mentioning

confidence: 99%

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

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“…The development of stable, safe, fat emulsions (Schuberth and Wretlind, 1962) ---~ further studies of intensive parenteral feeding in the postoperative period. Holden, Krieger, Levey, and Abbott (1957) found that large amounts of calories and protein hydrolysates given intravenously reduced the nitrogen deficit after operation.…”

Section: Introductionmentioning

confidence: 99%

The effect of intravenous feeding on the balances of nitrogen, sodium, and potassium after operation

Johnston

Marino

Stevens

1966

Journal of British Surgery

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The value of intravenous nutrients in reducing the postoperative negative balance of nitrogen and associated loss of body-weight is uncertain. Metabolic balance studies of amino acids, nitrogen, sodium, and potassium were carried out on 30 men, aged 25 to 60 years, for 5 days after vagotomy and drainage for duodenal ulcer.The patients were divided into 5 groups: a control group had fluids only and no calories; amino acids (0.15 g. nitrogen/kg./day) and few calories had no effect on the nitrogen balance in a second group; the addition of calories as fat emulsion (35 cals/kg./day) reduced, but did not abolish, the negative balance of nitrogen (0.05 > F;.0.02); anabolic steroids had no effect on the utilization of intravenous nutrients after operation; intravenous feeding was more efficient than comparable amounts of nutrients given intrajejunally.Intravenous nutrients contain large amounts of sodium and negligible quantities of potassium. Sodium balances remained strongly positive after operation. Potassium losses were considerable and serum levels fell after 4 or 5 days.When the daily postoperative intake of amino acids was constant, the mean proportion retained was least on the third day (70 per cent) and greatest on the fifth day (90 per cent).Intravenous nutrients appear to be of more value towards the end of the catabolic response to injury, and their use should be considered at that time if normal feeding cannot be resumed. Numerous physical and histological studies on woun? healing have led to the idea of a metabolically inert 'lag phase (Slome, 1961) which lasts for 3-5 days after injury. The earliest changes escape observation when examined by routine histological techniques. Enzyme histochemistry gives a better picture of the functional state of cells and tissues and is thus more suitable for detection of the first reactions in wounded tissue. Studies of alkaline phosphatase, acid phosphatase, cytochrome oxidase, and succinate dehydrogenase activities were undertaken on wounds in albino rats and guinea-pigs. Enzyme activity was studied at intervals from half an hour to one week after wounding. Comparative histological changes and an estimation of cell glycogen were also made.In the immediate vicinity of the wound there is a central zone of decreased enzyme activity: surrounding this a peripheral zone exhibited increased enzyme activity which appears 1-8 hours after wounding. This initial increase seemed to indicate an adaptive defence mechanism by local connective-tissue cells in response to injury i: Raekallio, 1964). The enzymes in the outer zone of the wound may play a part in more specific regenerative processes. It seems probable that the production of the enzymes studied is the earliest step in the process of repair which begins in the so-called 'lag' phase of wound healing. RAEKALLIO The exact method of placentation in the higher primates is unknown. It has been suggested that the chorionic villi act like malignant cells, burrowing their way into the endometrium which tends to resist their invasion...

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“…1,2 Incorporation of additional non-nutritional lipophilic compounds into these emulsions has been suggested for numerous other medical applications ranging from improved therapeutic and controlled-release profiles for drugs or prodrugs to the delivery of contrast agents used in diagnostic imaging procedures. 3 For example, oil-in-water emulsion formulations have been developed to provide sustained release or reduced systemic toxicity for antineoplastic agents, 4,5 anesthetics, 6,7 vaccine adjuvants, 8 and anti-inflammatory agents.…”

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confidence: 99%

Physicochemical Characterization of a Synthetic Lipid Emulsion for Hepatocyte-Selective Delivery of Lipophilic Compounds: Application to Polyiodinated Triglycerides as Contrast Agents for Computed Tomography

Bakan

Longino

Weichert

et al. 1996

Journal of Pharmaceutical Sciences

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A synthetic lipid emulsion (LE) has been developed with physicochemical properties that closely resemble those of a specific class of naturally-occurring lipoproteins known as chylomicron remnants. The formulation has the potential to serve as a hepatocyte-selective delivery system for any lipophilic or amphipathic compounds that can be associated with the internal lipid phase of the emulsion. In the present studies, a lipophilic polyiodinated triglyceride (ITG) was successfully incorporated into the delivery vehicle to form a stable chylomicron-remnant-like emulsion capable of localizing material to the liver following intravenous injection. The preferred ITG-LE formulation was shown to have a mean particle diameter of less than 200 nm and a particle size stability profile in excess of 12 months. The viscosity, pH, and osmolality of the formulation also appeared favorable for safe and convenient intravenous injection. The particle size profile, chemical properties, and high degree of incorporation of ITG into the emulsion suggest that the ITG-LE formulation holds substantial promise as a hepatocyte-selective imaging agent for computed tomography of the liver. Biodistribution, elimination, and computed tomography (CT) imaging results in animals corroborated the hepatocyte-selective nature of the ITG-LE formulation.

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Erfahrungen über intravenöse Fettemulsionen

Cited by 5 publications

References 0 publications

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

The effect of intravenous feeding on the balances of nitrogen, sodium, and potassium after operation

Physicochemical Characterization of a Synthetic Lipid Emulsion for Hepatocyte-Selective Delivery of Lipophilic Compounds: Application to Polyiodinated Triglycerides as Contrast Agents for Computed Tomography

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