ERG Protein Expression in Diagnostic Specimens Is Associated with Increased Risk of Progression During Active Surveillance for Prostate Cancer

Berg, Kasper Drimer; Vainer, Ben; Thomsen, Frederik Birkebæk; Røder, Martin Andreas; Gerds, Thomas Alexander; Toft, Birgitte Grønkær; Brasso, Klaus; Iversen, Peter

doi:10.1016/j.eururo.2014.02.058

Cited by 77 publications

(75 citation statements)

References 29 publications

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“…It was reported that the patients with high-grade prostatic intraepithelial neoplasia (HGPIN) who overexpressed ERG were more vulnerable to prostate cancer than their counterparts without ERG expression [30]. Over the past decade, accumulating evidence demonstrated that TMPRSS2:ERG fusion gene can be a potential tumor biomarker for detecting prostate cancer, particularly in Western countries [31,32]. Additionally, several studies implied that the expression level of ERG was related to clinical prognosis of patients with prostate cancer, suggesting that ERG could be a useful prognostic factor [33,34].…”

Section: Discussionmentioning

confidence: 98%

TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer

et al. 2016

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Prostate cancer is the commonest male malignancy in the Western world, but its morbidity is much lower in China. The principal aim of this study was to evaluate the frequency of TMPRSS2:ERG fusion in Chinese prostate cancer patients using immunohistochemistry and reverse transcription polymerase chain (RT-PCR). In addition, we compared the ERG protein expression with TMPRSS2:ERG fusion gene. The relationship between ERG expression and clinicopathologic features was also examined. Samples from patients who underwent radical prostatectomies in Changhai Hospital (Shanghai, China) were collected and stored in ethically approved tissue banks. One hundred seventy-four prostate cancer tissue samples and 10 normal tissues were marked on standard hematoxylin-eosin (HE) sections, punched out of the paraffin blocks and inserted into a recipient block using tissue arrayer instruments. Immunohistochemistry and RT-PCR were employed to detect TMPRSS2:ERG fusion gene. ERG was highly expressed in the nuclei of endothelial cells of vessels and weak cytoplasmic staining was occasionally observed. ERG positive staining was present in 14.9 % (26/174) of the tumor samples in microarray. All benign prostate samples were found to be negative. RT-PCR results revealed that 11.1 % (15/135) were TMPRSS2:ERG fusion positive. Altogether, there was a good agreement of ERG immunostaining with the presence of TMPRSS2:ERG. However, no correlation was observed between ERG expression and age, Gleason score, stage, surgical margin, and seminal vesicle involvement in Chinese patients. In the present study, we identified a high correlation between ERG expression and ERG TMPRSS2:ERG, with 100 % sensitivity and 88.9 % specificity. The expression level of ERG was unrelated to the age, Gleason score, stage, surgical margin, and seminal vesicle involvement. Therefore, the association between ERG expression and prostate cancer based on Chinese population should be further investigated in the future.

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Section: Discussionmentioning

confidence: 98%

TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer

et al. 2016

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“…Patients were followed up with prostate-specific antigen measurements, digital rectal examinations, and 10–12 core rebiopsies as previously published 5. Based on protocolled progression criteria,15 89 patients underwent RP.…”

Section: Methodsmentioning

confidence: 99%

“…We have previously reported that patients with ERG-positive tumours managed on AS have 2.5-fold increased hazard of disease progression as compared with patients with ERG-negative tumours 5. However, the impact of sampling error and the extent of ERG reclassification over time are unknown.…”

Section: Introductionmentioning

confidence: 99%

ERG protein expression over time: from diagnostic biopsies to radical prostatectomy specimens in clinically localised prostate cancer

et al. 2015

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“…Similarly, Leinonen and coworkers found no association between TMPRSS2:ERG fusion status and outcome among ADT-treated patients [36]. A recent study investigated TMPRSS2:ERG fusion status from biopsies of 265 active surveillance (AS) patients and found that TMPRSS2:ERG fusion-positive patients had a significantly higher risk of disease progression (hazard ratio: 2.45) compared with fusion-negative patients [37]. However, another study of PCa patients on AS showed that urinary TMPRSS2:ERG and the prostate cancer antigen 3 (PCA3) gene were not significant independent predictors of biopsy reclassification on multivariable analysis [38].…”

Section: Tmprss2:erg Fusionmentioning

confidence: 99%

Genomic Predictors of Outcome in Prostate Cancer

et al. 2015

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ERG Protein Expression in Diagnostic Specimens Is Associated with Increased Risk of Progression During Active Surveillance for Prostate Cancer

Cited by 77 publications

References 29 publications

TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer

TMPRSS2:ERG fusion gene occurs less frequently in Chinese patients with prostate cancer

ERG protein expression over time: from diagnostic biopsies to radical prostatectomy specimens in clinically localised prostate cancer

Genomic Predictors of Outcome in Prostate Cancer

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