ERG sensitivity and rhodopsin content of the isolated human retina

Bender, Silvia; Baumann, Ch.

doi:10.1007/bf00592791

Cited by 9 publications

(1 citation statement)

References 16 publications

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“…Secondly, the rods may actually receive synaptic input from the cones. Schwartz (1973) (Custer, 1972(Custer, , 1973 (Donner & Reuter, 1967, 1968Baumann & Scheibner, 1968;Siliman, Owen & Fernandez, 1972Ernst & Kemp, 1972;Donner, 1973;Bender & Baumann, 1973). However, photoproduct involvement has been discounted in both vertebrate and invertebrate receptors by other investigators (Frank & Dowling, 1968;Frank, 1971;Fein & DeVoe, 1973;Hillman, Dodge, Hoclistein, Knight & Mfinke, 1973).…”

Section: Dark-adaptation Op Axolotl Rodsmentioning

confidence: 99%

Intracellular recordings of rod responses during dark‐adaptation.

Grabowski¹,

Pak²

1975

The Journal of Physiology

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SUMMARY1. Dark-adaptation of rod photoreceptors has been studied in the isolated axolotl (Ambystoma mexicanum) retina by intracellular recordings. Rod responsiveness was greatly reduced immediately after a 30 sec partial bleach, but partially recovered with time in the dark.2. In parallel spectrophotometric measurements using isolated retinas, regeneration of the rod pigment could not be detected after a 30 sec bleach.3. During rod dark-adaptation, the response of a rod to a given stimulus increased in amplitude, duration, and rate of rise but did not recover completely to the dark-adapted values. Response latency was lengthened immediately after a bleach but ultimately returned to the dark-adapted level.4. The time courses of dark-adaptation determined on the basis of the intensity of a stimulus needed to evoke a response having a criterion amplitude, a criterion duration, or a criterion rate of rise were similar. On the other hand changes in latency of the response and magnitude of the saturated amplitude followed different time courses. Change in log threshold was found to be related to change. in saturated amplitude by an exponential function during dark-adaptation.5. After bleaching 10 % or less of the rod pigment, the kinetics of both recovery of log threshold and decrease in absorbance at 400 nm (metarhodopsin II +free retinal) could be described by two concurrent firstorder processes having similar time constants. However, after bleaching more than 10 % of the rod pigment, changes in sensitivity and absorbance did not follow parallel time courses. 6. Metarhodopsin III cannot be solely responsible for setting the axolotl rod sensitivity since rod thresholds decrease monotonically during dark-adaptation whereas meta III concentration reaches a peak 3 min after the bleach and decreases thereafter.

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Section: Dark-adaptation Op Axolotl Rodsmentioning

confidence: 99%

Intracellular recordings of rod responses during dark‐adaptation.

Grabowski¹,

Pak²

1975

The Journal of Physiology

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The Perfused Cat Eye: A Model in Neurobiologic Research

Niemeyer¹

1977

Current Research in Ophthalmic Electron Microscopy

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The perfused cat eye: A model in neurobiologic research

Niemeyer¹

1977

Albrecht von Graefes Arch. Klin. Ophthalmol.

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The viability of an arterially perfused mammalian eye preparation is demonstrated in (1) electrophysiological recordings of multineuronal responses (electroretinogram, optic nerve action potential) as well as of signals from single cells (ganglion cells, horizontal cells, pigment epithelium), and (2) in a quantitative analysis of the fine structure of the retina. The possibilities of assessing the function of the retina at several levels of information processing and of controlling the biochemical input without systemic effects favor pharmacologic studies in vitro. Results from our research on cholinergic transmission in the cat retina are presented, revealing reversible effects of physostigmine, atropine, scopolamine and mecamylamine on the activity of ganglion cells.

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ERG sensitivity and rhodopsin content of the isolated human retina

Cited by 9 publications

References 16 publications

Intracellular recordings of rod responses during dark‐adaptation.

Intracellular recordings of rod responses during dark‐adaptation.

The Perfused Cat Eye: A Model in Neurobiologic Research

The perfused cat eye: A model in neurobiologic research

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