Ergebnisse der intravenösen Implantation von Impftumoren

Combined surgery and chemotherapy in the treatment of malignant tumors

“…Unaware of this work, we started a series of experiments in 1955 in order to find out if the mortality rate due to secondary growth following radical operation could be decreased by means of postoperative chemotherapy. Results of these experiments have been published elsewhere.13, 14, [42][43][44][45][46] At first a series of experiments was performed on 4,000 rats and 1,250 mice imitating the invasion of tumor cells into the blood stream and its consequences in human patients. We injected 1 to 2 million cells of reticulum cell-like sarcoma Yoshida, carcinosarcoma 256 Walker, or ascites tumor Ehrlich into the tail vein, obtaining tumor growth in 80 to l O O~& T h e animals died in 10 to 20 From the Austrian Cancer Research Institute, Vienna, Austria.…”