Ergolytic drugs in medicine and sports

Eichner, E. Randy

doi:10.1016/0002-9343(93)90185-r

Cited by 37 publications

(15 citation statements)

References 43 publications

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“…Ergolytic eVects (impaired exercise performance) of alcohol have been described (Eichner 1993) and a signiWcant dose-dependent slowing eVect on sprinting and middle distance running has been reported (McNaughton and Preece 1986). However, in two controlled studies by Lundin et al (1986) and Clarkson and Reichsman (1990) evaluating concentric or eccentric muscle performance, respectively, no adverse eVect was found during alcohol intoxication when compared to non-intoxicated condition.…”

Section: Introductionmentioning

confidence: 93%

Motor performance during and following acute alcohol intoxication in healthy non-alcoholic subjects

et al. 2007

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Chronic alcohol abuse has adverse effects on skeletal muscle, and reduced muscle strength is frequently seen in chronic alcoholics. In this study the acute effects of moderate alcohol intoxication on motor performance was evaluated in 19 non-alcoholic healthy subjects (10 women, 9 men). A randomised double-blinded placebo controlled design was applied to subjects receiving alcohol in juice and pure juice at two separate test periods. Isokinetic and isometric muscle strength and endurance were determined before, during, 24 and 48 h after the ingestion of alcohol in juice and juice (placebo). To detect a reduced activation of the central motor pathways superimposed external electrical stimulations during voluntary contractions were applied. Creatine kinase (CK) was measured to detect any alcohol-induced changes in sarcolemmal integrity. No change was seen in isokinetic as well as in isometric muscle performance during or following the alcohol intoxication as compared to the non-alcoholic condition. Also, no central activation failure was observed. No significant difference in CK increment was observed comparing the alcoholic- and non-alcoholic condition. In conclusion, a single episode of moderate alcohol intoxication (1,4 g/l) does not impair motor performance, and no accelerated exercise-induced muscle damage is seen.

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Section: Introductionmentioning

confidence: 93%

Motor performance during and following acute alcohol intoxication in healthy non-alcoholic subjects

et al. 2007

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“…A characteristic feature of chronic alcohol consumption is a wasting of skeletal muscle mass that is most apparent in fasttwitch type II muscle fibers (36). Even acute alcohol intoxication can cause reversible skeletal muscle dysfunction (16). Paradoxically, evidence from epidemiological studies has demonstrated a consistent association between alcohol intake and cardiovascular disease (CVD) (1,9,15).…”

mentioning

confidence: 99%

Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle

Gavin

Wagner

2002

Journal of Applied Physiology

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“…Nevertheless, the control of water retention caused by the use of anabolic steroids is another frequent use of diuretics. [3,5,6] Gas chromatography coupled with mass spectrometric detection (GC/ MS), as well as high performance liquid chromatography (HPLC), are the techniques used for screening diuretics in doping control urinalyses.…”

Section: Introductionmentioning

confidence: 99%

“…Whenever used prior to sports activities, they are considered ergolitic agents decreasing the athletes' performance due to a rapid reduction of plasmatic volume. [3] Even so, these drugs were included in the list of prohibited substances by the International Olympic Committee in 1986. Since then, diuretics have been subject to doping control in sports activities.…”

Section: Introductionmentioning

confidence: 99%

Liquid Chromatographic Screening Test for Some Diuretics of Doping Interest in Human Urine

Moreira

Moreau

2005

Journal of Liquid Chromatography & Related Technologies

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Despite being considered ergolytic drugs, diuretics have been included on the lists of prohibited substances of the International Olympic Committee since 1986 due to their capacity of masking doping agents in urine. As diuretics are also prone to be misused regarding weight categories, screening procedures to check their presence in urine, whenever doping control is involved, are mandatory. A simple screening method using liquid-liquid extraction was validated for the compounds: acetazolamide, amiloride, bumetanide, chlorthalidone, clopamide, furosemide, hydrochlorothiazide, piretamide, spironolactone, and triamterene. Urine samples were extracted in both acidic and basic media. HPLC analyses were performed with a Spherisorb ODS column and diode array UV detector, set at 260, 270, and 360 nm wavelengths. A gradient mobile phase was used. Limits of detection varied from 0.09 to 0.75 mg/mL. Recoveries ranged from 55.26 to 94.82%. Inter and intra-assay precision tests showed good values.

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Ergolytic drugs in medicine and sports

Cited by 37 publications

References 43 publications

Motor performance during and following acute alcohol intoxication in healthy non-alcoholic subjects

Motor performance during and following acute alcohol intoxication in healthy non-alcoholic subjects

Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle

Liquid Chromatographic Screening Test for Some Diuretics of Doping Interest in Human Urine

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