Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation

Sillapachaiyaporn, Chanin; Chuchawankul, Siriporn; Nilkhet, Sunita; Moungkote, Nuntanat; Sarachana, Tewarit; Ung, Alison T.; Baek, Seung Joon; Tencomnao, Tewin

doi:10.1016/j.foodres.2022.111433

Cited by 30 publications

(14 citation statements)

References 43 publications

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“…Ergosterol, the major product of mycosterol biosynthesis, is an important component of fungal cell membranes that maintain membrane structural integrity, permeability, and fluidity, which can promote the absorption of calcium and phosphorus in the human body. It is one of the good sources of exogenous vitamin D2 in the human body and is often used to improve rickets, osteomalacia, and osteoporosis caused by vitamin D deficiency in infants and elderly people [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

A New Species Agrocybe striatipes, also a Newly Commercially Cultivated Mushroom with Highly Nutritional and Healthy Values

Yang

Ren

et al. 2023

JoF

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The species of Agrocybe (Strophariaceae, Agaricales, Agaricomycetes) are saprophytic and widely distributed in temperate regions. In this study, a new species named Agrocybe striatipes from China is described, which has been successfully cultivated in China recently. The phenotypic characteristics examination and molecular phylogenetic analyses using multilocus data (ITS and nrLSU) both support it as a new species in the genus Agrocybe. Moreover, nutritional ingredient analysis showed that the fruiting body of A. striatipes was rich in seventeen amino acids, including eight essential amino acids, in addition to high levels of calcium (78.5 mg/kg) and vitamin D (44.1 μg/100g). The following analysis of the heavy metal contents of the fruiting bodies show that it does not contain lead, cadmium, arsenic, mercury, and other heavy metal elements. In the crude extract of the mushroom, the nutrients in the aqueous phase are amino acids and oligosaccharides, and the active substances in the ethyl acetate layer are sterols, which have a variety of pharmacological effects. In conclusion, A. striatipes is not only a new species but also has highly application values as a cultivated edible mushroom in nutrition and health.

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Section: Resultsmentioning

confidence: 99%

A New Species Agrocybe striatipes, also a Newly Commercially Cultivated Mushroom with Highly Nutritional and Healthy Values

Yang

Ren

et al. 2023

JoF

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“…Some studies found that BPA exposure through gestational and postnatal stages reduced the total spine density in the hippocampus of male offspring [ 11 , 12 ]. Moreover, BPA causes neuroinflammation by microglial activation [ 122 ], suggesting that BPA may negatively impact the microglia-mediated synaptic pruning process after birth. The effects of BPA on changes in synaptic formation and synaptic pruning processes in the offspring brain from embryonic to adult stages should be investigated further.…”

Section: Discussionmentioning

confidence: 99%

Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus

et al. 2023

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Background Bisphenol A (BPA) has been linked to susceptibility to autism spectrum disorder (ASD). Our recent studies have shown that prenatal BPA exposure disrupted ASD-related gene expression in the hippocampus, neurological functions, and behaviors associated with ASD in a sex-specific pattern. However, the molecular mechanisms underlying the effects of BPA are still unclear. Methods Transcriptome data mining and molecular docking analyses were performed to identify ASD-related transcription factors (TFs) and their target genes underlying the sex-specific effects of prenatal BPA exposure. Gene ontology analysis was conducted to predict biological functions associated with these genes. The expression levels of ASD-related TFs and targets in the hippocampus of rat pups prenatally exposed to BPA were measured using qRT-PCR analysis. The role of the androgen receptor (AR) in BPA-mediated regulation of ASD candidate genes was investigated using a human neuronal cell line stably transfected with AR-expression or control plasmid. Synaptogenesis, which is a function associated with genes transcriptionally regulated by ASD-related TFs, was assessed using primary hippocampal neurons isolated from male and female rat pups prenatally exposed to BPA. Results We found that there was a sex difference in ASD-related TFs underlying the effects of prenatal BPA exposure on the transcriptome profiles of the offspring hippocampus. In addition to the known BPA targets AR and ESR1, BPA could directly interact with novel targets (i.e., KDM5B, SMAD4, and TCF7L2). The targets of these TFs were also associated with ASD. Prenatal BPA exposure disrupted the expression of ASD-related TFs and targets in the offspring hippocampus in a sex-dependent manner. Moreover, AR was involved in the BPA-mediated dysregulation of AUTS2, KMT2C, and SMARCC2. Prenatal BPA exposure altered synaptogenesis by increasing synaptic protein levels in males but not in females, but the number of excitatory synapses was increased in female primary neurons only. Conclusions Our findings suggest that AR and other ASD-related TFs are involved in sex differences in the effects of prenatal BPA exposure on transcriptome profiles and synaptogenesis in the offspring hippocampus. These TFs may play an essential role in an increased ASD susceptibility associated with endocrine-disrupting chemicals, particularly BPA, and the male bias of ASD.

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“…Further investigation in LPS-treated ICR mice found that ergosterol exhibited anti-neuroinflammatory activity and maintained the synaptic proteins. Another group also reported that ergosterol isolated from Auricularia polytricha or Cordyceps militaris attenuated neuroinflammation in BV2 cells ( Nallathamby et al, 2015 ; Sillapachaiyaporn et al, 2022a ), and exhibited neuroprotective activity in TNF-α-induced HT-22 cells via regulating the expression of N-methyl-D-aspartate receptors (NMDARs) and antioxidant enzyme, and cell survival pathways ( Sillapachaiyaporn et al, 2022b ). Therefore, ergosterol exerts its neuroprotective effect mainly through its anti-neuroinflammatory property via multiple pathways.…”

Section: Neuroprotection Potential Of Acmentioning

confidence: 99%

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Li,

Wan,

Qiao

et al. 2024

Front. Pharmacol.

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Prevalent neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and stroke are increasingly becoming a global burden as society ages. It is well-known that degeneration and loss of neurons are the fundamental underlying processes, but there are still no effective therapies for these neurological diseases. In recent years, plenty of studies have focused on the pharmacology and feasibility of natural products as new strategies for the development of drugs that target neurological disorders. Antrodia camphorata has become one of the most promising candidates, and the crude extracts and some active metabolites of it have been reported to play various pharmacological activities to alleviate neurological symptoms at cellular and molecular levels. This review highlights the current evidence of Antrodia camphorata against neurological disorders, including safety evaluation, metabolism, blood-brain barrier penetration, neuroprotective activities, and the potential on regulating the gut-microbiome-brain axis. Furthermore, potential strategies to resolve problematic issues identified in previous studies are also discussed. We aim to provide an overview for the ongoing development and utilization of Antrodia camphorata in cerebral neuropathology.

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Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation

Cited by 30 publications

References 43 publications

A New Species Agrocybe striatipes, also a Newly Commercially Cultivated Mushroom with Highly Nutritional and Healthy Values

A New Species Agrocybe striatipes, also a Newly Commercially Cultivated Mushroom with Highly Nutritional and Healthy Values

Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

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