Summary: The analysis of social inequalities can no longer be confined to the national context. The sociology of social inequalities increasingly has to deal with multiple territorial scales as inequalities are generated and regulated in a regionalnational-European and global multi-level system. On the basis of micro-data it can be shown that both the level and the unequal distribution of disposable income in Europe do not depend on household characteristics alone, but also on regional economic and labor market structures, on national institutions, on European integration, and on the European and global opening of markets to capital, labor and goods. Despite the harsh criticism of methodological nationalism in inequality research, the national level is empirically still the most important level of analysis. Nation-states continue to exert a high level of influence on the distribution of income by regulating education, social welfare, and markets. At the same time, previously closed national spaces of inequality become increasingly permeable through processes of supra-national integration and sub-natinal differentiation. The national, sub-and supranational determinants of income levels and inequalities are analyzed in this contribution on the basis of EU-SILC data for the period 2005-2008 using multilevel modeling.