Eriodictyol suppresses the malignant progression of colorectal cancer by downregulating tissue specific transplantation antigen P35B (TSTA3) expression to restrain fucosylation

Huang, Hua; He, Yun; Li, Youran; Gu, Mingjia; Wu, Minna; Ji, Lijiang

doi:10.1080/21655979.2022.2039485

Cited by 12 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to our results, kaempferol, astragalin and tiliroside seem to reveal higher activity towards examined factors than p -coumaric acid, which is in accordance with Pei et al [ 14 ], who suggested that activity of coumaric acid increases after the formation of conjugates. It has been also demonstrated that tiliroside bearing p -coumaroyl moiety exhibited higher antioxidant and cytoprotective effect than astragalin [ 45 ].…”

Section: Discussionsupporting

confidence: 92%

“…It has been reported that many polyphenolic compounds exhibit anti-tumor functions by controlling cell viability or inducing apoptosis. Their application in cancer treatment gains attention due to their safety, efficiency and low side effects [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Altered glycosylation is also considered as a hallmark of carcinogenesis with involvement in the disease outcome [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…p -Coumaric acid (4-hydroxycinnamic acid) ( Figure 1 A) is phenolic acid found ubiquitously in plants and mushrooms, in free or bound forms, revealing various bioactivities, including anti-cancer property. It can be subsequently transformed to other flavonoids [ 14 ]. Kaempferol ( Figure 1 B), a flavonoid widely present in many fruits, vegetables and traditional herbal medicines, has been reported as a cancer therapeutic agent by its anti-proliferative action, promoting autophagy and apoptosis [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

p-Coumaric acid, Kaempferol, Astragalin and Tiliroside Influence the Expression of Glycoforms in AGS Gastric Cancer Cells

Radziejewska

Supruniuk

Izdebska

et al. 2022

IJMS

View full text Add to dashboard Cite

Abnormal glycosylation of cancer cells is considered a key factor of carcinogenesis related to growth, proliferation, migration and invasion of tumor cells. Many plant-based polyphenolic compounds reveal potential anti-cancer properties effecting cellular signaling systems. Herein, we assessed the effects of phenolic acid, p-coumaric acid and flavonoids such as kaempferol, astragalin or tiliroside on expression of selected cancer-related glycoforms and enzymes involved in their formation in AGS gastric cancer cells. The cells were treated with 80 and 160 µM of the compounds. RT-PCR, Western blotting and ELISA tests were performed to determine the influence of polyphenolics on analyzed factors. All the examined compounds inhibited the expression of MUC1, ST6GalNAcT2 and FUT4 mRNAs. C1GalT1, St3Gal-IV and FUT4 proteins as well as MUC1 domain, Tn and sialyl T antigen detected in cell lysates were also lowered. Both concentrations of kaempferol, astragalin and tiliroside also suppressed ppGalNAcT2 and C1GalT1 mRNAs. MUC1 cytoplasmic domain, sialyl Tn, T antigens in cell lysates and sialyl T in culture medium were inhibited only by kaempferol and tiliroside. Nuclear factor NF-κB mRNA expression decreased after treatment with both concentrations of kaempferol, astragalin and tiliroside. NF-κB protein expression was inhibited by kaempferol and tiliroside. The results indicate the rationality of application of examined polyphenolics as potential preventive agents against gastric cancer development.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

p-Coumaric acid, Kaempferol, Astragalin and Tiliroside Influence the Expression of Glycoforms in AGS Gastric Cancer Cells

Radziejewska

Supruniuk

Izdebska

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Various studies have described an in vitro anti–CRC activity of flavanones such as naringin, liquiritigenin and eriodictyol [ 43 , 44 , 45 ]. Naringin has been suggested to affect CRC through NF–κB/IL–6/STAT3, PI3K/AKT/mTOR, apoptosis, NF–κB–COX–2–iNOS and β–catenin pathways [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Liquiritigenin has been shown to affect HCT116 CRC cell line downregulating the expression of Runx2 and inactivating the PI3K/AKT pathway [ 44 ]. Eriodictyol seems to affect CRC cells by suppressing fucosylation and downregulating STAT3 expression [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Flavonoid Intake in Relation to Colorectal Cancer Risk and Blood Bacterial DNA

et al. 2022

View full text Add to dashboard Cite

Flavonoids have been inversely associated to colorectal cancer (CRC) and are plausible intermediaries for the relation among gut microbiome, intestinal permeability and CRC. We analyzed the relation of flavonoid intake with CRC and blood bacterial DNA. We conducted a case–control study in Italy involving 100 incident CRC cases and 200 controls. A valid and reproducible food–frequency questionnaire was used to assess dietary habits and to estimate six flavonoid subclass intakes. We applied qPCR and 16S rRNA gene profiling to assess blood bacterial DNA. We used multiple logistic regression to derive odds ratios (ORs) of CRC and Mann–Whitney and chi-–square tests to evaluate abundance and prevalence of operational taxonomic units (OTUs) according to flavonoid intakes. Inverse associations with CRC were found for anthocyanidins (OR for the highest versus the lowest tertile = 0.24, 95% confidence interval, CI = 0.11–0.52) and flavanones (OR = 0.18, 95% CI = 0.08–0.42). We found different abundance and prevalence according to anthocyanidin and flavanone intake for OTUs referring to Oligoflexales order, Diplorickettsiaceae family, Staphylococcus, Brevundimonas, Pelomonas and Escherischia–Shigella genera, and Flavobacterium and Legionella species. The study provides evidence to a protective effect of dietary anthocyanidins and flavanones on CRC and suggests an influence of flavonoids on blood bacterial DNA, possibly through intestinal permeability changes.

show abstract

Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.

Tang

Lin

Yan

et al. 2023

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Eriodictyol suppresses the malignant progression of colorectal cancer by downregulating tissue specific transplantation antigen P35B (TSTA3) expression to restrain fucosylation

Cited by 12 publications

References 34 publications

p-Coumaric acid, Kaempferol, Astragalin and Tiliroside Influence the Expression of Glycoforms in AGS Gastric Cancer Cells

p-Coumaric acid, Kaempferol, Astragalin and Tiliroside Influence the Expression of Glycoforms in AGS Gastric Cancer Cells

Flavonoid Intake in Relation to Colorectal Cancer Risk and Blood Bacterial DNA

Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.

Contact Info

Product

Resources

About