Erken Laktasyon Süresince Sütçü İneklerde Niasin İlavesinin Metabolik Parametreler ve Lipoliz Üzerine Etkisi

Abstract

Citation of This Article AbstractThe objective of this study was to evaluate the effect of niacin on the metabolic parameters and lipolysis inhibition in dairy cows during early lactation. A total of 30 clinically healthy, multiparous Holstein-Friesian cows in late gestation were enrolled in the study (15 supplemented with niacin (120 g/d/ cow) and 15 in the negative control group). Blood samples were taken weekly for 3 weeks after calving. The research results show that cows that received niacin indicated lower NEFA concentrations in all three weeks of the experiment. The NEFA concentrations did not change from weeks 0 to 2 after calving in the niacin group, whereas the NEFA concentrations in the control group were significantly increased (P<0.05). The administration of niacin exerted significant effects on the metabolic adaptations in cows during early lactation. Niacin significantly decreased BHB, MDA, total bilirubin, urea and phosphorus concentrations and liver enzyme activity (AST, ALP and GGT) and increased albumin, cholesterol, triglyceride and glucose concentrations. The administration of niacin significantly affected the correlation and regression between NEFA concentrations and other metabolic parameters, rendering the glucose, cholesterol, triglycerides, total bilirubin, AST, albumin, urea and phosphorus values less regressed against the NEFA values. In conclusion, niacin administration decreases lipolysis and metabolic adaptations proved to be less dependent on NEFA concentrations in niacin group compared to the control group. Keywords: Cow, Niacin, Lipolysis, Metabolic profile Erken Laktasyon Süresince Sütçü İneklerde Niasin İlavesinin Metabolik Parametreler ve Lipoliz Üzerine Etkisi ÖzetBu çalışmanın amacı erken laktasyon süresince sütçü ineklerde niasinin metabolic parametreler ve lipolizi inhibe etme üzerine etkilerini araştırmaktır. Toplam 30 adet klinik olarak sağlıklı geç gebelik dönemindeki multiparous Holstein-Friesian inek (15'i 120 g/gün niasin takviyesi verilmiş ve 15'i negatif kontrol) çalışmada kullanıldı. Kan örnekleri doğumu takiben 3 hafta süresince haftalık olarak alındı. Çalışma sonuçları niasin alan ineklerde 3 hafta süresince NEFA konsantrasyonunun daha düşük olduğunu gösterdi. NEFA konsantrasyonu 0 ile doğumdan sonraki 2 hafta boyunca niasin grubunda değişmezken kontrol grubunda anlamlı oranda artma gösterdi (P<0.05). Niasin verilmesi erken laktasyon dönemindeki ineklerdeki metabolik adaptasyona anlamlı derecede etki etti. Niasin anlamlı oranda BHB, MDA, total bilirubin, üre ve fosfor konsantrasyonları ile karaciğer enzim aktivitesini (AST, ALP ve GGT) düşürürken albümin, kolesterol, trigliserid ve glikoz konsantrasyonlarını artırdı. Niasin verilmesi anlamlı oranlarda olmak üzere NEFA konsantrasyonları ile diğer metabolik parametreler arasındaki korelasyon ve regresyonu etkiledi. Glikoz, kolesterol, trigliserid, total bilirubin, AST, albümin, üre ve fosfor değerleri NEFA değerlerine göre daha az gerileme gösterdi. Sonuç olarak, niasin verilmesi lipolizi azaltırken metabolik ada...

The effects of supplemental niacin and methionine on serum glucose, beta-hydroxybutyric acid, and non-esterified fatty acid levels during late gestation and early postpartum period in Damascus dairy goats

“…Nicotinic acid also depresses lipolysis in the fat tissue thereby reducing NEFA levels. Decreased NEFA concentrations, on the other hand, reduce triglyceride accumulation and ketone formation in the liver [15,23,25]. Keeping in view these effects, it is suggested that dietary supplementation of Nia might have decreased blood NEFA and β-HBA levels while increasing blood glucose levels [23,24].…”

“…Feed supplements like L-carnitine, chrome, propylene glycol, sodium propionate, ionophores, niacin (Nia), and methionine (Met) have been proposed to prevent this metabolic disorder [13,14]. Nia and Met are known for their roles in the suppression of lipolysis in transition dairy cows to regulate the hepatic lipid metabolism [15,16]. However, there is no known study available in the literature that describes the effects of using supplemental Nia and Met on pregnancy toxicity in the late gestation and early postpartum period of the goats.…”

Düşük Nişastalı Rasyonlarla Beslenen Geçiş Dönemindeki İneklerde Amilaz Enziminin Etkisi: 2. Toplam Sindirilebilirlik ve Kan Üre Azotu

“…There are studies in which some feed additives [8][9][10] and treatments [11] was used for transition dairy cows. In addition, exogenous amylase was evaluated in some trials to improve performance [12][13][14] and digestibility [15,16] .…”