Erlotinib and Garcinia Cambogia Prevent Adenine Induced Nephrotoxicity in Adult Male Albino Rats Through Modulating EKR1/2, STAT3, and p53 Apoptotic Pathways

Abstract

C hronic renal disease (CRD) has a significant negative effect on public health and exihibited a significant cause of a disease that affects more than 200 million people globally (Manoj and Hartmann, 2019). CRD forced patients to undergo terrible medical procedures, which drastically reduced their quality of life. The morbidity and mortality problem is getting worse every year (Ali et al., 2017). Up till now, dialysis or kidney transplantation are the only available treatment options as, and there hasn't been at least one medicine discovered that can be utilized to sustain kidney function in CRD patients (Cai et al., 2018).To delay the reduce in kidney function, it is necessary to discover beneficial therapies or nutritional supplements. It is undeniable that oxidative stress, inflammation, and ap-