Ernährungsphysiologische Untersuchungen mit Isomaltit an der Ratte

Musch, K.; Siebert, Günther; Schiweck, H.; Steinle, Georg

doi:10.1007/978-3-662-41451-4_2

Cited by 5 publications

(13 citation statements)

References 25 publications

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“…If the fermentative capacity had been exceeded, diarrhoea1 symptoms via the osmotic activity of intact carbohydrates (Saunders & Wiggins, 1981) should have occurred. It should be mentioned here also that undegraded Palatinit in stools in men (Musch et al 1973) and animals (Grupp & Siebert, 1978;Kirchgessner et al 1983; S. C. Ziesenitz, R. Vallon, E. J. Karle, C. Benning and G. Siebert, unpublished results) has never resulted in excretion levels exceeding 1% of the oral dose.…”

Section: Discussionmentioning

confidence: 83%

Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture, Palatinit®

1985

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1. Breath hydrogen and methane were determined by gas chromatography in eleven normal individuals given a low-fibre, mixed diet (control) and after ingestion of 20-50 g Palatinit@/d, an equimolar mixture of Dglucosyl-a( I + l)-D-mannitol and D-glUCOSyl-a( 1 + 6)-~-glucitol (Isomalt@).2. A linear relation was found (r 0.85; P < 0.001) between the amount of Palatinit ingested and breath H, per 10 h in subjects who did not exhale methane. If methane was formed in addition to H,, the sum of both gases followed a linear dose-effect relation.3. The mouth-to-caecum time, indicated by the first increase in breath H, after ingestion, was shortened by about half, yet no sign of diarrhoea was observed. Stool weight and stool frequency did not change significantly. The linear relation between a dose of 20-50 g Palatinit and exhalation of H, (eventually plus methane)indicated that a relatively constant fraction of the dose given underwent cleavage and absorption in the small intestine, the remainder being transported into the large bowel. Microbial gas formation in the colon as well as the fractional transfer of these gases into the expiratory air occurred at fixed proportions, thus allowing an insight into colonic microbial contributions to carbohydrate utilization in the human large bowel.

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Section: Discussionmentioning

confidence: 83%

Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture, Palatinit®

1985

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“…Its occurrence cannot be explained except by the assumption that small amounts o f the disaccharide alcohol are absorbed without cleavage from the intestine, as already reported in experiments with rats (2).…”

Section: Resultsmentioning

confidence: 73%

Studies on Isomaltitol

Siebert¹,

Grupp²,

Heinkel³

1975

Ann Nutr Metab

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“…The present study is in consequence concerned with the digestibility of hydrogenated palatinose and the energetic utilisation of its cleavage products in the metabolism of man and rat. Several short communications have appeared since this work was started [22,40,52,53].…”

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confidence: 99%

Metabolism of hydrogenated palatinose, an equimolar mixture ofα-D-glucopyranosido-1,6-sorbitol andα-D-glucopyranosido-1,6-mannitol

Grupp

Siebert

1978

Res. Exp. Med.

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Hydrogenated palatinose, an equimolar mixture of alpha-D-glucopyranosido-1,6-sorbitol and alpha-D-glucopyranosido-1,6-mannitol, was investigated as a potential oral sugar substitute in the following experiments in man and rat. 1. Enzymatic cleavage occurred at slow rates by maltase (alpha-glucosidase) of jejunal mucosa, liver lysosomes and yeast. 2. Part of ingested hydrogenated palatinose arrived unsplit at the caecum of the rat and underwent fermentation there; excretion in feces and urine are neglegible in man and rat. 3. Growth and maintenance of rats demonstrated 20--40 percent diminished caloric utilisation of diets containing 34.5 percent hydrogenated palatinose whereas indirect calorimetry in man showed about 50 percent caloric deficit. 4. Blood sugar did not increase in man after oral doses up to 100 g. 5. The capacity of the rat kidneys for excretion of hydrogenated palatinose and its constituents was high, symptoms of incompatibility were not observed.

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Ernährungsphysiologische Untersuchungen mit Isomaltit an der Ratte

Cited by 5 publications

References 25 publications

Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture, Palatinit®

Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture, Palatinit®

Studies on Isomaltitol

Metabolism of hydrogenated palatinose, an equimolar mixture ofα-D-glucopyranosido-1,6-sorbitol andα-D-glucopyranosido-1,6-mannitol

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