Erosive pustular dermatosis of the scalp: A review with a focus on dapsone therapy

Broussard, Karen; Berger, Timothy G.; Rosenblum, Michael D.; Murase, Jenny E.

doi:10.1016/j.jaad.2011.10.011

Cited by 66 publications

(75 citation statements)

References 29 publications

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“…Treatments reported in the literature gave different results and include topic and systemic drugs, photodynamic therapy and surgery. Broussard et al report 4 patients with EPDS treated successfully with topical dapsone 5% gel (12). This therapy seems to effective but is the result of a limited experience and in our opinion might be considered as a secondary choice, in case of failure to steroids, and tacrolimus.…”

Section: Discussionmentioning

confidence: 81%

Erosive pustular dermatitis of the scalp: case series

Stan¹

2014

CDERM

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SummaryBackground. Erosive pustular dermatitis of the scalp, also known as amicrobial pustulosis of the scalp, is a rare chronic disorder of unknown etiology mainly reported in elderly individuals. It is characterized by sterile pustules, erosions and crusted lesions, which ultimately result in scarring alopecia. Chronic sun exposure and androgenic alopecia are considered risk factors, and mechanical and chemical traumas are reported to trigger the disease. Objective. To evaluate prevalence of the disease and risk factors, pathological features and outcome in series of patients. Methods. All medical records of patients with a diagnosis of EPDS made between

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Section: Discussionmentioning

confidence: 81%

Erosive pustular dermatitis of the scalp: case series

Stan¹

2014

CDERM

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“…De mayor ocurrencia en personas añosas y calvas, con predominio del sexo femenino. Si bien su patogénesis no es del todo conocida, se ha observado una aparición posterior a trauma local como: radioterapia, injertos, craneotomía, crioterapia, aplicación de sustancias irritantes como tratamientos con 5-fluorouracilo, láser, exposición prolongada a radiación UV 3 . Se ha reportado una posible asociación con enfermedades autoinmunes como: artritis reumatoide, hepatitis autoinmune, tiroiditis de Hashimoto y arteritis de Takayasu; sin embargo, no se ha podido establecer una conexión patogénica directa 4 .…”

Section: Discussionunclassified

“…En la terapia de primera línea se encuentran los corticoides tópicos de alta potencia como el clobetasol al 0,05% y retinoides orales, otros tratamientos propuestos incluyen corticoides tópicos, tacrolimus tópico, dapsona oral, calcipotriol tópico, dapsona gel al 5%, terapia con Sulfato de Zinc oral. Estos han demostrado buenos resultados con algunos meses de tratamiento [3][4][5][6][7] . Se encuentran también en la literatura tratamientos exitosos con terapia fotodinámica con Ácido 5-Aminolevulínico 8 .…”

Section: Figuraunclassified

Pustulosis aguda erosiva del cuero cabelludo

Llancapi

Delgado

2018

Rev. chil. dermatol

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ResumenLa Pustulosis Erosiva del cuero cabelludo fue descrita por primera vez por Pye, Peachy y Burton en 1979, en mujeres mayores¹. De etiología y patogenia no del todo clara, se relaciona con exposición a trauma local. Se presenta como lesiones erosivas, costrosas y pustulosas de carácter estéril. Su cuadro histológico no es específico, por lo que el diagnóstico es de exclusión. Se han reportado múltiples tratamientos, pero los que han demostrado mejor resultado se basan en el uso de corticoides tópicos de alta potencia y retinoides orales.Presentamos un caso de pustulosis erosiva del cuero cabelludo en un paciente varón y una revisión de los principales aspectos clínicos e histopatológicos de esta enfermedad.Palabras claves: Pustulosis Erosiva del Cuero Cabelludo; Diagnóstico; Tratamiento. summaRyIn 1979 Pye, Peachy and Burton described the Erosive Pustular Dermatosis of the scalp in elder women. The etiology and pathogenesis is still unknown; nonetheless, it is most commonly associated with the exposure to local trauma. The disease is manifested as sterile erosive, crusty and pustular lesions on the scalp. Its histological profile is unspecific; therefore, it is a diagnosis of exclusion. Multiple treatments have been reported, high-potency topical corticosteroids and oral retinoids have shown favorable response. Herein we present a case of an erosive pustular dermatosis of the scalp on a male patient and a review of the clinical and histological characteristics of this disease.

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“…15,29 Other case reports describe topical dapsone treating dermatitis herpetiformis, venous stasis ulcers, erosive pustular dermatosis of the scalp, erythema elevatum diutinum, granuloma faciale, lupus erythematosus, and hidradenitis suppurativa. 13,[30][31][32][33][34] No adverse events or safety concerns were reported in these studies.…”

Section: Case Reportsmentioning

confidence: 99%

Status Report on the Safety of Topical Dapsone Therapy for Dermatologic Disease

Winkelmann

Rosso

2018

J of Skin

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Systemic dapsone therapy has historically been used to treat leprosy, inflammatory dermatoses, and severe cases of acne vulgaris. This article reviews the pharmacokinetics, short and long-term safety, drug-drug interactions, gender, and age effects of topical dapsone 5% and 7.5% gel formulations. In 20 human studies and 7 case reports, 39 of 6,384 total patients (<1%) experienced adverse effects that were considered more than mild or resulted in discontinuation of topical dapsone. The literature supports topical dapsone 5% and 7.5% gels as safe and effective medications for the treatment of dermatologic disease.

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Erosive pustular dermatosis of the scalp: A review with a focus on dapsone therapy

Cited by 66 publications

References 29 publications

Erosive pustular dermatitis of the scalp: case series

Erosive pustular dermatitis of the scalp: case series

Pustulosis aguda erosiva del cuero cabelludo

Status Report on the Safety of Topical Dapsone Therapy for Dermatologic Disease

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