Erosive Pustular Dermatosis of the Scalp Responding to Acitretin

Darwich, Esteve

doi:10.1001/archdermatol.2010.442

Cited by 24 publications

(31 citation statements)

References 5 publications

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“…[78] Histopathologically, EPDS is non-specific, showing atrophic epidermis and chronic inflammation consisting of lymphocytes, neutrophils, plasma cells, and occasional foreign body giant cells. [13] Erosive pustular dermatosis of the scalp is a diagnosis of exclusion,[14] based on histopathological and microbiological examination,[13] with a wide list of differential diagnoses including bacterial or fungal infection, pemphigus, squamous cell carcinoma and dermatitis artefacta, folliculitis decalvans, pyoderma gangrenosum, and cicatricial pemphigoid. [913] The nonspecific histopathological pattern, the evolution leading to scarring alopecia, and the resistance to antibiotics, with response to steroids, favor such a diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Erosive pustular dermatosis of the scalp following hair transplantation

2014

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Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disease with unknown etiology that usually occurs in the elderly. It is characterized by multiple sterile pustules, chronic crusted erosions, cicatricial alopecia, and skin atrophy. It typically develops in aged or sun-damaged skin and is most often accompanied by a history of local trauma. Histopathologically, non-specialized change manifests as atrophic epidermis and chronic inflammation. Although this disease mainly occurs in elderly white women, we here report a case of EPDS in a 35-year-old man, following hair transplantation as a local trauma, that was successfully treated with topical steroid.

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Section: Discussionmentioning

confidence: 99%

Erosive pustular dermatosis of the scalp following hair transplantation

2014

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“…2,3 The pathogenesis is unknown, but factors such as local trauma, topical 5-fluorouracil, surgery, cryotherapy, radiotherapy, laser treatment, irritant contact dermatitis, imiquimod, herpes zoster and prolonged exposure to ultraviolet radiation were suggested as triggers. 4,5,6,7 Association with autoimmune diseases like rheumatoid arthritis, autoimmune hepatitis, Hashimoto's thyroiditis and Takayasu arteritis have been reported. 4 The patient had two episodes of local trauma in different time periods and suspicion of herpes zoster, which may have been triggering factors.…”

Section: Discussionmentioning

confidence: 99%

“…(4.5) EPDS presents no pathognomonic laboratory and histopathological findings, it is an clinical diagnosis of exclusion . 7 The finding of pustules, erosions and crusts on the scalp of elderly patients, with nonspecific histology, absence of microorganisms and resistance to antibiotics leading to scarring alopecia allows the diagnosis. 4 …”

Section: Discussionmentioning

confidence: 99%

Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus

Zahdi

Seidel

Soares

et al. 2013

An. Bras. Dermatol.

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Erosive pustular dermatosis of the scalp is a rare inflammatory disorder of the scalp, affecting elderly patients after local trauma and leading to scarring or cicatricial alopecia. Case Report: An elderly female patient complained of painful pustules on the parietal region bilaterally with progressive enlargement and ulceration. A biopsy suggested erosive pustular dermatosis of the scalp and the patient was treated with prednisone 40 mg/day and 0.1% topical tacrolimus. After 10 weeks complete closure of the eroded areas was observed and a stable scarring alopecia developed.

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“…Its etiology is unknown, although some triggering factors are implicated, such as prolonged exposure to ultraviolet radiation, local trauma, phototherapy, cryotherapy, radiotherapy [6], and treatment with laser [7]. It is proposed that the physical trauma would stimulate the production of autoantibodies against skin structures, resulting in a secondary inflammatory reaction [8].…”

Section: Answermentioning

confidence: 99%

“…The topical use of tacrolimus, calcipotriol [12], and oral treatments with nimesulide, acitretin, isotretinoin, and zinc sulfate are reported [4,7,13,14]. There are reports of the use of topical and systemic corticoids and dapsone [4,13].…”

Section: Answermentioning

confidence: 99%