ERP and fMRI measures of visual spatial selective attention

Mangun, George R.; Buonocore, Michael H.; Girelli, Massimo; Jha, Amishi P.

doi:10.1002/(sici)1097-0193(1998)6:5/6<383::aid-hbm10>3.3.co;2-q

Cited by 71 publications

(85 citation statements)

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“…In particular, if the benefits of SSRIs relate to the core deficits of autism, as seems to be the case clinically, this would strongly support the equivalency of some forms of autism with major psychiatric disorders. An important aspect of this concept is the recognition of high-functioning autism, in particular, as a disorder primarily of left-hemisphere language and semantic/contextual function, with preservation of functions (mainly visuospatial skills and veridical rote memory) associated with the right hemisphere (Mangun et al 1998). Such a pattern of disturbance would correspond to the low left-hemisphere serotonin found with C 11 -AMT PET scans in young boys with autism (Chugani et al 1997, DeLong 1999.…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement

DeLong

Ritch

Burch

2002

Develop Med Child Neuro

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One hundred and twenty‐nine children, 2 to 8 years old, with idiopathic autistic spectrum disorder diagnosed by standard instruments (Childhood Austim Ratings Scale and Autism Diagnostic Observation Schedule) were treated with fluoxetine (0.15 to 0.5mg/kg) for 5 to 76 months (mean 32 to 36 months), with discontinuation trials. Response criteria are described. Family histories were obtained using the family history method in repeated interviews. Fluoxetine response, family history of major affective disorder, and unusual intellectual achievement, pretreatment language, and hyperlexia were used to define a coherent subgroup of autistic spectrum disorder. Statistical analyses were post hoc. Of the children, 22 (17%) had an excellent response, 67 (52%) good, and 40 (31%) fair/poor. Treatment age did not correlate with response. Fluoxetine response correlated robustly with familial major affective disorder and unusual intellectual achievement, and with hyperlexia in the child. Family history of bipolar disorder and of unusual intellectual achievement correlated strongly. Five children developed bipolar disorder during follow‐up. Fluoxetine response, family history of major affective disorder (especially bipolar), unusual achievement, and hyperlexia in the children appear to define a homogeneous autistic subgroup. Bipolar disorder, unusual intellectual achievement, and autistic spectrum disorders cluster strongly in families and may share genetic determinants.

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Section: Discussionmentioning

confidence: 99%

Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement

DeLong

Ritch

Burch

2002

Develop Med Child Neuro

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“…The visual module was previously assumed to correspond to activity in the fusiform gyrus, but actually seems to respond better to activity in the middle occipital gyrus, at least for the five tasks that we analyzed. The middle occipital gyrus is typically involved in visual-spatial attention (22,35). Given that the visual regressor that we used corresponds to attending objects, this seems to be a sensible match.…”

Section: Auralmentioning

confidence: 99%

Using model-based functional MRI to locate working memory updates and declarative memory retrievals in the fronto-parietal network

Borst

Anderson

2013

Proc. Natl. Acad. Sci. U.S.A.

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In this study, we used model-based functional MRI (fMRI) to locate two functions of the fronto-parietal network: declarative memory retrievals and updating of working memory. Because regions in the fronto-parietal network are by definition coherently active, locating functions within this network is difficult. To overcome this problem, we applied model-based fMRI, an analysis method that uses predictions of a computational model to inform the analysis. We applied model-based fMRI to five previously published datasets with associated computational cognitive models, and subsequently integrated the results in a meta-analysis. The meta-analysis showed that declarative memory retrievals correlated with activity in the inferior frontal gyrus and the anterior cingulate, whereas updating of working memory corresponded to activation in the inferior parietal lobule, as well as to activation around the inferior frontal gyrus and the anterior cingulate.I n this study, we used model-based functional MRI (fMRI) to locate two functions of the so-called "fronto-parietal network." The fronto-parietal network consists of brain areas that are coherently active and assumed to implement cognitive control functions: working memory, attentional selection, and error monitoring (1-5). It typically involves at least the dorsolateral prefrontal cortex, the anterior cingulate, and a region around the intraparietal sulcus. Because the regions in the fronto-parietal network are by definition active at the same time, distinguishing the precise functional characteristics of those regions is difficult with conventional fMRI methods. Model-based fMRI is particularly well suited for dissociating between highly correlated contributions to the blood oxygen level-dependent (BOLD) signal. We used model-based fMRI to locate two functions within the fronto-parietal network: declarative memory retrieval and updating of working memory. These functions are often assumed to be part of the fronto-parietal network, but the hypothesized locations within the network differ among studies (2, 6-11).Model-based fMRI is a relatively recent approach to analyzing fMRI data. Instead of using the condition structure of the experiment to inform the analysis, as in a conventional fMRI analysis, model-based fMRI uses information derived from a computational model (12, 13). For example, Daw et al. (14) fitted a mathematical reinforcement learning model to the behavior of their study participants and then used parameter values of the model as regressors in the fMRI analysis. This resulted in brain regions that correlated significantly with those parameter values, and thus with certain features of their model. Another recent study showed that modelbased fMRI can be used successfully in combination with more high-level information-processing models (15). By regressing the activity of model components (e.g., visual processing, declarative memory retrieval) against neural activity, the neural correlates of the model components can be located.To identify the neural correlates o...

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“…However, we still lack a detailed retinotopic map of later components, which are more commonly studied in the ERP literature, such as P1 and N1 (Di Russo et al, 2012;Klimesch, 2011;Mangun et al, 1998). For instance, it has recently been demonstrated that the amplitude of some components such as P1 or the face-sensitive N170 is modulated by the gaze fixation position within a face (Zerouali et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Retinotopic mapping of visual event-related potentials

Capilla

Melcón

Kessel

et al. 2016

Biological Psychology

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Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in:Biological Psychology 118 (2016) ABSTRACTVisual stimulation is frequently employed in electroencephalographic (EEG) research.However, despite its widespread use, no studies have thoroughly evaluated how the morphology of the visual event-related potentials (ERPs) varies according to the spatial location of stimuli. Hence, the purpose of this study was to perform a detailed retinotopic mapping of visual ERPs. We recorded EEG activity while participants were visually stimulated with 60 pattern-reversing checkerboards placed at different polar angles and eccentricities. Our results show five pattern-reversal ERP components. C1and C2 components inverted polarity between the upper and lower hemifields. P1 and N1 showed higher amplitudes and shorter latencies to stimuli located in the contralateral lower quadrant. In contrast, P2 amplitude was enhanced and its latency was reduced by stimuli presented in the periphery of the upper hemifield. The retinotopic maps presented here could serve as a guide for selecting optimal visuo-spatial locations in future ERP studies. HIGHLIGHTS Extensive and multichannel retinotopic mapping of major visual ERP components. C1 and C2 components showed inverted polarity for upper and lower hemifields. P1 and N1 components were larger when the contralateral lower field was stimulated. P2 showed higher amplitude and shorter latency for peripheral upper field stimuli. Present results can be used to select optimal stimulus locations in ERP designs.

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ERP and fMRI measures of visual spatial selective attention

Cited by 71 publications

References 0 publications

Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement

Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement

Using model-based functional MRI to locate working memory updates and declarative memory retrievals in the fronto-parietal network

Retinotopic mapping of visual event-related potentials

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