Erratum: Corrigendum: Independent optical excitation of distinct neural populations

Klapoetke, Nathan C.; Murata, Yasunobu; Kim, Sung Soo; Pulver, Stefan R.; Birdsey-Benson, Amanda; Cho, Yong Ku; Morimoto, Tania K.; Chuong, Amy S.; Carpenter, Eric J.; Tian, Zhendong; Wang, Jun; Xie, Yinlong; Yan, Zhixiang; Zhang, Yong; Chow, Brian Y.; Surek, Barbara; Melkonian, Michael; Jayaraman, Vivek; Constantine‐Paton, Martha; Wong, Gane Ka‐Shu; Boyden, Edward S.

doi:10.1038/nmeth0914-971d

Cited by 2 publications

(1 citation statement)

References 1 publication

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“…Moreover, the ChR2 gene has been modified to produce a "bistable" channel also known as step-function opsin (SFO). This channel is opened by one wavelength and closed by a different wavelength [9,15]. Due to the blood-brain barrier (BBB), the delivery of proteins to the brain is difficult.…”

Section: Basic Concept Of Optogeneticsmentioning

confidence: 99%

Optogenetics: Therapeutic spark in neuropathic pain

Liu

Wang

2019

Bosn J of Basic Med Sci

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Optogenetics is an emerging field, which uses light and molecular genetics to manipulate the activity of live cells by expressing light-sensitive proteins. With the discovery of bacteriorhodopsin, a light-sensitive bacterial protein, in 1971 Oesterhelt and Stoeckenius laid the pavement of optogenetics. However, the cross-integration of different disciplines is a little more than a decade old. The toolbox contains fluorescent sensors and optogenetic actuators which enable visualization of signaling events and manipulation of cellular activities, respectively. Neuropathic pain is a pain caused either by damage or disease that affects the somatosensory system. The exact mechanism for the neuropathic pain is not known, however proposed mechanisms include immune reactions, ion channel expressions, and inflammation. Current regimen for the disease provides about 50% relief for only 40-60% of patients. Recent in vivo and in vitro studies demonstrate the potential therapeutic applications of optogenetics by manipulating the activity of neurons. This review summarizes the basic concept, therapeutic applications for neuropathy and potential of optogenetics to reach from bench to bedside in the near future.

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Section: Basic Concept Of Optogeneticsmentioning

confidence: 99%

Optogenetics: Therapeutic spark in neuropathic pain

Liu

Wang

2019

Bosn J of Basic Med Sci

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Long-range GABAergic projections contribute to cortical feedback control of sensory processing

Mazo

Saha

Nissant

et al. 2020

Preprint

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In sensory systems, cortical areas send excitatory projections back to subcortical areas to dynamically adjust sensory processing. Here, we uncover for the first time the existence of a cortical inhibitory feedback to subcortical sensory areas. Investigating the olfactory system, we reveal that a subpopulation of GABAergic neurons in the anterior olfactory cortex target the olfactory bulb. Analogous inhibitory cortico-thalamic projections were also present in the somatosensory system. Long-range inhibitory inputs synapsed with both local and output neurons of the olfactory bulb. At the functional level, optogenetic activation of cortical GABAergic projections caused a net subtractive inhibition of both spontaneous and odor-evoked activity in local as well as output projection neurons, mitral and tufted cells. In tufted cells, but not mitral cells, this resulted in an enhanced separation of population odor responses. Furthermore, GABAergic corticofugal projections entrained network oscillations in the communication band between the cortex and the olfactory bulb. Targeted pharmacogenetic silencing of the cortical GABAergic outputs in the olfactory bulb impaired discrimination of similar odor mixtures. Thus, cortical GABAergic feedback represents a new circuit motif in sensory systems involved in refining sensory processing and perception.

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Erratum: Corrigendum: Independent optical excitation of distinct neural populations

Cited by 2 publications

References 1 publication

Optogenetics: Therapeutic spark in neuropathic pain

Optogenetics: Therapeutic spark in neuropathic pain

Long-range GABAergic projections contribute to cortical feedback control of sensory processing

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