Erratum for the Research Article: “Engineering a highly elastic human protein–based sealant for surgical applications” by N. Annabi, Y.-N. Zhang, A. Assmann, E. S. Sani, G. Cheng, A. D. Lassaletta, A. Vegh, B. Dehghani, G. U. Ruiz-Esparza, X. Wang, S. Gangadharan, A. S. Weiss, A. Khademhosseini

doi:10.1126/scitranslmed.aaw0535

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…To quantify the adhesive strength of L 18 –P (0.7, 24 h) –G 50 on different substrates, the lap shear test method was used for 180° peeling (Figure g). As shown in Figure 3h, L 18 –P (0.7, 24 h) –G 50 had room-temperature adhesion strengths of 26.9 ± 0.71, 59.1 ± 3.57, 64.3 ± 3.82, and 66.8 ± 6.55 kPa on pigskin, silicone rubber, iron sheet, and glass, respectively, which are comparable to those of the commercially available sealants, such as Evicel and Coseal . The adhesiveness of the hydrogels could be primarily attributed their its capability for polymer adsorption of L and strong interfacial interactions between glycerol and the substrates .…”

Section: Results and Discussionmentioning

confidence: 70%

Conductive Hydrogels with Ultrastretchability and Adhesiveness for Flame- and Cold-Tolerant Strain Sensors

Liu

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Hydrogel strain sensors with extreme temperature tolerance have recently gained great attention. However, the sensing ability of these hydrogel strain sensors changes with temperature, resulting in the variety of output signals that causes signal distortion. In this study, double-network hydrogels comprising SiO 2 nanoparticles composed of polyacrylamide and phytic aciddoped polypyrrole were prepared and applied on strain sensors with a wide sensing range, high adhesiveness, and invariable strain sensitivity under flame and cold environments. The hydrogels had stable conductivity, excellent adhesive strength of up to 79.7 kPa on various substrates, and high elongation of up to 1896% at subzero temperature and after heating. They also exhibited effective flame retardancy with low surface temperature (71.2 °C) after 1200 s of heating (200 °C) and antifreezing properties at a low temperature of −20 °C. Remarkably, even under cold temperature and heat treatment, the hydrogel-based strain sensor displayed consistent sensing behaviors in detecting human motions with a broad strain range (up to 500%) and steady gauge factor (GF, ∼2.90). Therefore, this work paves the way for the applications of hydrogel sensors in robotic skin, human−mechanical interfaces, and health monitoring devices under harsh operating environments.

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Section: Results and Discussionmentioning

confidence: 70%

Conductive Hydrogels with Ultrastretchability and Adhesiveness for Flame- and Cold-Tolerant Strain Sensors

Liu

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Silk‐Inspired In Situ Hydrogel with Anti‐Tumor Immunity Enhanced Photodynamic Therapy for Melanoma and Infected Wound Healing

Tang

Chen

Zhang

et al. 2021

Adv Funct Materials

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Easy cancer recurrence and wound infections have been clinical challenges after surgical treatment of melanoma. Herein, a silk‐inspired in situ gelation system containing methacrylated silk fibroin (SF) and chlorine e6 for improved cancer therapy with enhanced wound healing is developed. Favored by the macrophage recruitment capacity of the SF hydrogel, promising antitumor immune responses can be turned “on” via near infrared irradiation in a controllable manner to achieve combination therapy with photodynamic therapy to significantly suppress melanoma recurrence. Moreover, the effective photodynamic antibacterial activity of this bioactive system with the capacity of light‐controllable modulating macrophage phenotype promotes remarkable tissue ingrowth with hair follicle regeneration for Staphylococcus aureus infected wound healing. Thus, this multifunctional silk‐based hydrogel system, as a desirable wound dressing, provides a new platform for promising melanoma therapy and skin regeneration.

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Bioinspired Non-Immunogenic Multifunctional Sealant for Efficient Blood Clotting and Suture-Free Wound Closure

Ghosh

Gayen

Jan

et al. 2020

ACS Biomater. Sci. Eng.

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Engineering bioinspired peptide-based molecular medicine is an emerging paradigm for the management of traumatic coagulopathies and inherent bleeding disorder. A hemostat-based strategy in managing uncontrolled bleeding is limited due to the lack of adequate efficacy and clinical noncompliance. In this study, we report an engineered adhesive peptide-based hybrid regenerative medicine, sealant 5, which is designed integrating the structural and functional features of fibrin and mussel foot-pad protein. AFM studies have revealed that sealant 5 (55.8 ± 6.8 nN adhesive force) has higher adhesive force than fibrin (46.4 ± 7.3 nN adhesive force). SEM data confirms that sealant 5 retains its network-like morphology both at 37 and 60 °C, inferring its thermal stability. Both sealant 5 and fibrin exhibit biodegradability in the presence of trypsin, and sealant 5 also showed biocompatibility in the presence of fibroblast cells. Engineered sealant 5 efficiently promotes hemostasis with enhanced adhesiveness and less blood-loss than fibrin. In vivo data suggests that in heparinized conditions, sealant 5 ceases bleeding at 212.3 ± 15.1 s, whereas fibrin halts bleeding at 294.3 ± 21.4 s and blood-loss is ∼4-fold less in sealant 5 than in fibrin. In a heparinized system, sealant 5 facilitates faster blood-clotting than fibrin (∼82 s faster) and RADA-16, a reported peptide-based sealant (∼113 s faster). Additionally, in the case of sealant 5, the process of clotting mimicry-like fibrin is independent of the body's own coagulation system. Sealant 5 efficiently halts bleeding for both external and internal wounds, even for a heparinized system overcoming the bacterial infection. ELISA data and PMBC cell proliferation data support the nonimmunogenic feature of sealant 5. Though fibrin and sealant 5 have exhibited comparable efficacy in suture-free wound closure, in vivo H&E staining images have revealed infiltration of very few immune cells as well as the presence of abundant collagen formation in the case of sealant 5-treated wound. Such nature-inspired non-immunogenic sealants offer exciting possibilities for the treatment of uncontrolled bleeding vis-a-vis wound closure.

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Cited by 3 publications

References 56 publications

Conductive Hydrogels with Ultrastretchability and Adhesiveness for Flame- and Cold-Tolerant Strain Sensors

Conductive Hydrogels with Ultrastretchability and Adhesiveness for Flame- and Cold-Tolerant Strain Sensors

Silk‐Inspired In Situ Hydrogel with Anti‐Tumor Immunity Enhanced Photodynamic Therapy for Melanoma and Infected Wound Healing

Bioinspired Non-Immunogenic Multifunctional Sealant for Efficient Blood Clotting and Suture-Free Wound Closure

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