Erratum: Observational study of subclinical diabetic macular edema

Elman, Michael J.; Sloan, Michelle D.; Starr, Jo Ann; Butcher, Theresa M.; Singletary, Pamela; Gore, Nancy; Coffey, Teresa; Andreani, Giorya Shabi; Sotirakos, Peter; Cain, Terri; Sharuk, G.; Arrigg, Paul G.; Schlossman, Deborah K.; Murtha, T. J.; Sun, Jennifer K.; Shah, Sabera T.; Stockman, Margaret E.; Kopple, Ann; Cavicchi, Robert W.; Stone, Thomas W.; Kitchens, John W.; Wood, William J.; Buck, Michelle; Arsdall, Jeanne Van; Cruz, Judith L.; Slade, Edward A.; Blevins, Stephen T.; Browning, David J.; Antoszyk, Andrew N.; Brooks, Danielle R.; Helms, Jennifer V.; Price, Angela; Cowen, Melissa K.; Karow, Angella S.; Murphy, Heather L.; McOwen, Michael; Davis, Linda M.; Clark, Loraine; Balasubramaniam, Uma; McClain, Donna; Powers, Michele; Braverman, Jon M.; Ciardella, Antonio P.; Ryman, Leif S.; Montalvo, Sasha I.; Zapata, Janelle Dane; Rhodes, Rosemary C.; Brown, Danielle; Lyon, Alice T.; Gill, Manjot K.; Kaminski, L.; Ackatz, Lori E.; O'Donnell, Laima M.; Shankle, Jonathan; Ryan, Dawn M.; Friedman, Scott M.; Blackmer, Kelly A.; Key, Jolleen S.; Sjoblom, Karen; Fagan, Damanda A.; Carlton, Steve; McKinney, Allen; Krzystolik, Magdalena G.; Savell, Mary B.; Henriques, Sandra; Bache, Joanne E.; Gross, Jeffrey G.; Flowers, Amy M.; Lovit, Heidi K.; Price, Randall; Kinyoun, James L.; Rath, Susan A.; Clifton, Brad C.; Leslie, J. D.; Beer, Paul M.; Garza, Denise; Olmeda, Eugenia; Whitney, Charisse; Fischer, Joe; Solomon, Sharon D.; Frey, Mary; West, S. K.; Donohue, D. J.; Graul, Janis; Emmert, David; Edwards, Paul; Rock, Sheila M.; Murphy, Janet E.; Rusinek, Brian A.; Troszak, Tracy A.; Davis, Garvin H.; Li, Helen K.; Spillar, Happy; Bourg, John M.; Crocker, Amber; Kelso, Craig N.; Cummings, Howard L.; Long, Deanna Jo; Carpenter, Stacy; Berry, Julie P.; Googe, Joseph M.; Higdon, Christina T.; Hunt, Cecile; Blais, Paul; Kim, Judy E.; Han, Dennis P.; Wirostko, William J.; Alvarez, Dawn; Graf, Jeanette; Flanders, Judy; Beringer, Joseph R.; Backes, Dennis B.; Chan, Clement K.; Walther, Kimberly S.; Castillo, Sandra U.; Huff, Kenneth M.; Chesbrough, Donna J.; Smith, Caldwell W.; Janigian, Robert H.; Woodcome, Harold A.; DuCoty, Collin L.; Varadian, Sylvia; Banalewicz, Erika; Hamel, Mark; Nagle, Alex L.; Bressler, Neil M.; Miller, Kellee M.; Beck, Roy W.; Bressler, Susan B.; Glassman, Adam R.; Melia, Michele

doi:10.1038/eye.2012.83

Cited by 2 publications

(2 citation statements)

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“…RT ‡ 290 lm in women and ‡ 305 lm in men for Cirrus SD-OCT subclinical macular edema (SME) [8][9][10] : RT > 260 lm and < 290 lm in women and > 275 lm and < 305 lm in men for Cirrus SD-OCT For the inner and outer rings (ClinicalTrials.gov number, NCT01331005) 11 :…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

OCT-Leakage: A New Method to Identify and Locate Abnormal Fluid Accumulation in Diabetic Retinal Edema

Cunha-Vaz

Santos

Ribeiro

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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METHODS. A cohort of 48 eyes from 48 type 2 diabetic patients with mild or moderate nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study levels 20/ 35) were classified as having normal RT (10), subclinical macular edema (30), or clinical macular edema (8). They were examined with Cirrus spectral-domain optical coherence tomography (OCT) at baseline visits (ClinicalTrials.gov number, NCT01145599) in the Coimbra center. Results from automated analysis of the retinal extracellular space, using our OCT-Leakage algorithm to identify sites of low optical reflectivity, were compared with those from a control group of 25 healthy eyes. RESULTS.The highest increases in RT in the eyes with subclinical and clinical macular edema were found in the inner nuclear layer (INL). These increases were, on average, 49.9% in subclinical macular edema and 104.7% in clinical macular edema. Extracellular space increases in the INL that were identified with the OCT-Leakage algorithm showed a strong positive correlation with the increases in RT in the central subfield (r ¼ 0.71, P < 0.001).CONCLUSIONS. Increases in number of sites with lower optical reflectivity positively correlate with the increase in RT in the initial stages of macular edema in diabetes type 2. Diabetic macular edema is represented mainly by extracellular fluid accumulation that preferentially involves the INL of the retina.

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Section: Optical Coherence Tomographymentioning

confidence: 99%

OCT-Leakage: A New Method to Identify and Locate Abnormal Fluid Accumulation in Diabetic Retinal Edema

Cunha-Vaz

Santos

Ribeiro

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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show abstract

“…To identify eyes/patients with increased RT in the central subfield (subclinical macular edema and clinical macular edema), the following reference values established by DRCR.net were used: for subclinical macular edema [2,5,6] , RT >260 and < 290 μm in women and >275 and < 305 μm in men (for Cirrus SD-OCT), and for clinical macular edema (ClinicalTrials.gov identifier: NCT01909791) [7] , RT ≥ 290 μm in women and ≥ 305 μm in men (for Cirrus SD-OCT).…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

One-Year Progression of Diabetic Subclinical Macular Edema in Eyes with Mild Nonproliferative Diabetic Retinopathy: Location of the Increase in Retinal Thickness

et al. 2015

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Purpose: To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. Methods: Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy Study) classified as presenting subclinical macular edema at baseline completed the 1-year follow-up period, from a sample of 194 followed in a 12-month observational and prospective study (ClinicalTrials.gov identifier: NCT01145599). Automated segmentation of the retinal layers in these eyes was performed, followed by verification and correction by a human grader. Results: The highest increase in RT over the 1-year follow-up period for the 48 eyes/patients with subclinical macular edema was found in the inner nuclear layer (INL). Progression to clinical macular edema was also associated with increased thickening of other retinal layers aside from the INL. The microvascular disease activity shown by microaneurysm (MA) turnover ≥6 was associated with progression from subclinical to clinical macular edema. Conclusions: Increases in RT occurring over a period of 1 year in diabetic eyes with mild NPDR and subclinical macular edema occur mainly in the INL. The development of clinical macular edema appears to be associated with increased thickening of other retinal layers and microvascular disease activity.

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Erratum: Observational study of subclinical diabetic macular edema

Abstract: The Diabetic Retinopathy Clinical Research Network Clinical Sites that participated on this protocol: Sites are listed in order by the number of subjects enrolled into the study. The number of subjects enrolled is noted in parenthesis preceded by the site location and the site name.

Cited by 2 publications

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OCT-Leakage: A New Method to Identify and Locate Abnormal Fluid Accumulation in Diabetic Retinal Edema

OCT-Leakage: A New Method to Identify and Locate Abnormal Fluid Accumulation in Diabetic Retinal Edema

One-Year Progression of Diabetic Subclinical Macular Edema in Eyes with Mild Nonproliferative Diabetic Retinopathy: Location of the Increase in Retinal Thickness

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