Erratum to: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study

Lee, Byung Ho; Inui, Daisuke; Suh, Gee Young; Kim, Jae Yeol; Kwon, Jae Young; Park, Jisook; Tada, Keiichi; Tanaka, Keiji; Ietsugu, Kenichi; Uehara, Kenji; Dote, Kentaro; Tajimi, Kimitaka; Morita, Kiyoshi; Matsuo, Koichi; Hoshino, Koji; Hosokawa, Koji; Lee, Kook Hyun; Lee, Kyoung Min; Takatori, Makoto; Nishimura, Masaji; Sanui, Masamitsu; Ito, Michiho; Egi, Moritoki; Honda, N; Okayama, Naoko; Shime, Nobuaki; Tsuruta, Ryosuke; Nogami, Satoshi; Yoon, Seong‐Ho; Fujitani, Shigeki; Koh, Shin Ok; Takeda, Satoru; Saito, Shinsuke; Hong, Sung Jin; Yamamoto, Takeshi; Yokoyama, Takeshi; Yamaguchi, Takuhiro; Nishiyama, Tomoki; Igarashi, Toshiko; Kakihana, Yasuyuki; Koh, Younsuck

doi:10.1186/cc11660

Cited by 78 publications

(36 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In these studies, the presence of fever was associated with either an increased risk of death [30], [39]- [41] or no diff erence in mortality risk compared to a normal temperature [34]. Only two studies have evaluated the mortality risk of patients with sepsis separately from patients without sepsis [33], [35]. In the fi rst study, fever was associated with an increased 28-day mortality risk in patients without sepsis but not in patients with sepsis [33] raising the possibility that the presence of infection might be an important determinant of the signifi cance of the febrile response in ICU patients.…”

Section: Fever In Icu Patients With Infections Observational Studies mentioning

confidence: 99%

“…Only two studies have evaluated the mortality risk of patients with sepsis separately from patients without sepsis [33], [35]. In the fi rst study, fever was associated with an increased 28-day mortality risk in patients without sepsis but not in patients with sepsis [33] raising the possibility that the presence of infection might be an important determinant of the signifi cance of the febrile response in ICU patients. Similarly, in a retrospective cohort study [35] (n = 636,051) using two independent, multicenter, geographically distinct and representative databases we found that peak temperatures above 39.0 °C in the fi rst 24 hours after ICU admission were generally associated with a reduced risk of in-hospital mortality in patients with an admission diagnosis of infection.…”

Section: Fever In Icu Patients With Infections Observational Studies mentioning

confidence: 99%

See 1 more Smart Citation

Fever Management in Intensive Care Patients with Infections

Young

Saxena

2014

Annual Update in Intensive Care and Emergency Medicine 2014

View full text Add to dashboard Cite

Section: Fever In Icu Patients With Infections Observational Studies mentioning

confidence: 99%

Section: Fever In Icu Patients With Infections Observational Studies mentioning

confidence: 99%

Fever Management in Intensive Care Patients with Infections

Young

Saxena

2014

Annual Update in Intensive Care and Emergency Medicine 2014

View full text Add to dashboard Cite

“…High temperatureespecially in the life-threatening situations-increases the metabolic rate, consumption of oxygen and affects the general outcomes. However, fever in other situation -especially in relation to infections-may work positively by fighting against the infective organism, decreasing the bacterial growth, and increasing the synthesis of antibodies and cytokines (10). Therefore, using antipyretic is a controversial issue.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, using antipyretic is a controversial issue. Acetaminophen is an antipyretic that is used commonly in ICU to treat fever (10). Although it shows a positive effect in reducing fever in ICU patients, there is a concern regarding using it frequently since it can act as a liver toxin by depleting the intracellular glutathione (9).…”

Section: Discussionmentioning

confidence: 99%

Acetaminophen in critically ill patients with fever

Mahmood¹

2016

IOSRPHR

View full text Add to dashboard Cite

Abstract:-Background: Acetaminophen is one of the most treatments used to reduce the temperature in ICU patients. However, it is still unclear whether the use of acetaminophen improves patients' survival and hospital length of stay. This study aims to analyze the main literatures which studied the use of acetaminophen in ICU patients with fever due to infections or other non-infectious insults. Methods:Severaldatabases including Cochrane library database, Academic Search Complete, and PubMed were searched for studies on acetaminophen in ICU patients. The search was limited to randomized controlled trials, cohort studies, adult human critically ill patients, treatment with acetaminophen in one arm and no treatment (placebo) in the other arm. The outcomes assessed were the ICU and hospital length of stay, mortality rate, ICU-free days and changes in temperature. Results:Two randomized control trials and one cohort study covering 32,408 patients were included. There wereno differences in ICU and hospital length of stay between the group treated with acetaminophen and placebo. In addition, the mortality rate did not differ between the two groups in patients with fever due to infection; however, a difference was shown in patients with fever due to non-infectious insults. Finally, there was a significant reduction in temperature in acetaminophen group compared to placebo. Conclusion: The use of acetaminophen for fever in critically ill patients was not associated with better outcome in terms of ICU and hospital length of stay and mortality ratecompared to placebo especially when the fever is due to infections.

show abstract

“…Septic patients, which present with or develop hypothermia, have a two-fold increase in mortality compared to febrile septic patients (41)(42)(43)(44). Furthermore, a very recent study proposes that the use of anti-pyretic agents in septic patients may be detrimental and should be avoided (45). These results suggest that fever has a beneficial effect on the host defense and the lack of fever, especially when hypothermia develops, is a marker of the failure of host defense.…”

Section: Cliniclal Importance Of Hypothermiamentioning

confidence: 99%

Pivotal role of Interleukin-10 on microRNA-155 expression in regulation of the monocyte response in hypothermia.

Billeter¹

View full text Add to dashboard Cite

Erratum to: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study

Cited by 78 publications

References 1 publication

Fever Management in Intensive Care Patients with Infections

Fever Management in Intensive Care Patients with Infections

Acetaminophen in critically ill patients with fever

Pivotal role of Interleukin-10 on microRNA-155 expression in regulation of the monocyte response in hypothermia.

Contact Info

Product

Resources

About