Erratum to: Concentration of antibodies against Porphyromonas gingivalisis increased before the onset of symptoms of rheumatoid arthritis

Johansson, Linda; Sherina, Natalia; Kharlamova, Nastya; Potempa, Barbara; Larsson, Barbro; Israelsson, Lena; Potempa, Jan; Rantapää‐Dahlqvist, Solbritt; Lundberg, Karin

doi:10.1186/s13075-016-1164-1

Cited by 3 publications

(2 citation statements)

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“…Porphyromonas gingivalis, the major periodontal pathogen (OR = 6.5; CI95: 1.40–30.21), possess the capacity to citrullinate host proteins via P. gingivalis (P)PAD production providing, by this way, the missing link between periodontitis and the development of RA [ 12 , 46 ]. The key role played by P. gingivalis on RA is further supported by the detection of IgG, most often IgG2 subclass, against P. gingivalis and against PPAD , which are increased at the pre-clinical stage and associated with ACPA while not with RF [ [47] , [48] , [49] , [50] ]. Moreover, the anti-bacterial protective variant of TLR4 (rs4986790), suspected first as protective factor for RA but not validated in a meta-analysis, is associated with P gingivalis detection (OR = 0.58, CI95: 0.36–0.98) [ 51 , 52 ].…”

Section: Factors Associated With a Mucosal Originmentioning

confidence: 99%

Causal risk and protective factors in rheumatoid arthritis: A genetic update

Arleevskaya

Takha

Petrov

et al. 2021

Journal of Translational Autoimmunity

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The characterization of risk and protective factors in complex diseases such as rheumatoid arthritis (RA) has evolved from epidemiological studies, which test association, to the use of Mendelian randomization approaches, which test direct relationships. Indeed, direct associations with the mucosal origin of RA are retrieved with periodontal disease ( Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans predominantly), interstitial lung involvement, tobacco smoking and air pollutants. Next, factors directly associated with an acquired immune response include genetic factors (HLA DRB1, PTPN22), capacity to produce anti-modified protein antibodies (AMPA), and relatives with a history of autoimmune diseases. Finally, factors can be also classified according to their direct capacity to interfere with the IL-6/CRP/sIL-IL6R proinflammatory pathway as risk factor (body fat, cardiometabolic factors, type 2 diabetes, depressive syndrome) or either as protective factors by controlling of sIL-6R levels (higher education level, and intelligence). Although some co-founders have been characterized (e.g. vitamin D, physical activity, cancer) the direct association with sex-discrepancy, pregnancy, and infections among other factors remains to be better explored.

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Section: Factors Associated With a Mucosal Originmentioning

confidence: 99%

Causal risk and protective factors in rheumatoid arthritis: A genetic update

Arleevskaya

Takha

Petrov

et al. 2021

Journal of Translational Autoimmunity

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“…There is currently a discussion about the importance of infection caused by Porphyromonas gingivalis, resulting in protein citrullination and hence leading to chronic periodontal disease as a triggering factor of RA development. De Smith et al [9] studied seropositive patients with arthralgia and seropositivity of antibodies against P. gingivalis and concluded that these antibodies do not predict RA development, but another study by Johansson et al [10] showed that antibodies against. P. gingivalis were increased in RA patients and may emerge years before the disease onset.…”

Section: Introductionmentioning

confidence: 99%

The place of omega-3 and omega-6 acids in supplementary treatment of inflammatory joint diseases

Kwiatkowska

Maślińska

2020

Reumatologia

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Eating habits have been analysed for years as a factor influencing the development of autoimmune diseases and susceptibility to infections. On the basis of research, observational studies and metaanalyses, special attention was paid to omega-3 and omega-6 acids. The purpose of the review is to show the importance of omega-3 and omega-6 acids as important ingredients in the healthy diet and as factors protecting against the development of the most common inflammatory rheumatic diseases. The influence of these omega-3 and-6 acids on the course of rheumatic diseases and arguments for their use as complementary therapy are also presented.

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Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals

Guo,

Wang,

et al. 2023

mSystems

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Although gut microbiota alteration and related blood microbe profiles in human immunodeficiency virus (HIV)-infected individuals are associated with the disease progression, how abnormal blood microbe profiles influence the inflammation and immune restoration are not fully understood. To address these issues, this study enrolled 24 healthy controls (HCs) and 91 HIV-infected individuals, including 30 treatment-naïve individuals (TNs), 31 immunological non-responders (INRs), and 30 immunological responders (IRs); subsequently, we analyzed blood microbe profiles using metagenomic sequencing and Olink proteomics technology, and identify inflammation-related proteins in peripheral blood samples of these individuals. The results showed increased translocation of microbes in the blood of TNs. This translocation did not return to normal level in either IRs or INRs who received antiretroviral therapy. In addition, Porphyromonas gingivalis significantly increased in TNs, IRs, and INRs compared to HCs. P. gingivalis was inversely associated with CD4 + T-cell counts, CD4/CD8 ratio, latency-associated peptide transforming growth factor-β1, and tumor necrosis factor-related activation-induced cytokine (TRANCE) and positively associated with HIV reservoirs. Burkholderia multivorans and Bacillus thuringiensis significantly decreased in TNs, IRs, and INRs compared to HCs and were positively associated with CD4 + T-cell counts and the CD4/CD8 ratio and negatively associated with HIV reservoir size and pro-inflammatory factors. We identified several species of microbes that were associated with CD4 + T-cell restoration on antiretroviral therapy, Prevotella sp . CAG:5226, Eubacterium sp . CAG:251, Phascolarctobacterium succinatutens, Anaerobutyricum hallii, Prevotella sp . AM34-19LB, and Phocaeicola plebeius were positively associated with HIV reservoir size and pro-inflammatory proteins. Another group of bacteria, B. multivorans, B. thuringiensis, Vibrio vulnificus, and Acinetobacter baumannii , which were negatively associated and pro-inflammatory proteins. In conclusion, different microbes within blood of HIV-infected individuals were found to be closely associated with persistent inflammation and immune restoration, suggesting the blood microbe profiles of HIV-infected individuals also influence disease progression. IMPORTANCE The characteristics of blood microbiota in HIV-infected individuals and their relevance to disease progression are still unknown, despite alterations in gut microbiota diversity and composition in HIV-infected individuals. Here, we present evidence of increased blood microbiota diversity in HIV-infected individuals, which may result from gut microbiota translocation. Also, we identify a group of microbes, Porphyromonas gingivalis , Prevotella sp. CAG:5226 , Eubacterium sp. CAG:251 , Phascolarctobacterium succinatutens , Anaerobutyricum hallii , Prevotella sp. AM34-19LB , and Phocaeicola plebeius , which are linked to poor immunological recovery. This work provides a scientific foundation toward therapeutic strategies targeting blood microbiota for immune recovery of HIV infection.

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Erratum to: Concentration of antibodies against Porphyromonas gingivalisis increased before the onset of symptoms of rheumatoid arthritis

Cited by 3 publications

References 1 publication

Causal risk and protective factors in rheumatoid arthritis: A genetic update

Causal risk and protective factors in rheumatoid arthritis: A genetic update

The place of omega-3 and omega-6 acids in supplementary treatment of inflammatory joint diseases

Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals

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