Erratum to: lack of immunity against rubella among Italian young adults

Gallone, Maria Serena; Gallone, Maria Filomena; Larocca, Angela Maria Vittoria; Germinario, Cinzia Annatea; Tafuri, Silvio

doi:10.1186/s12879-017-2724-y

Cited by 10 publications

(11 citation statements)

References 1 publication

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“…MMR vaccination has been covered by national health insurance that provides free of charge immunisation to all children aged ≤12 years, and clinical laboratory screening for rubella immunisation status using antirubella-specific IgG tests in pregnant women has been covered by the national health insurance free of charge for women visiting obstetrics clinics 17. Susceptible woman of childbearing age is indeed a priority, and public health efforts should be focused on catch-up activities in order to reduce the rate of susceptible young adults, especially for all women of childbearing age 23. Gynaecologists and general practitioners should be encouraged to propose rubella screening for women of childbearing age before they become pregnant to identify those women who lack rubella antibodies, whether acquired as the result of vaccination or a natural infection 23.…”

Section: Discussionmentioning

confidence: 99%

Recent trends in seroprevalence of rubella in Korean women of childbearing age: a cross-sectional study

Choi¹,

et al. 2020

BMJ Open

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ObjectivesThe aim of this study was to investigate the immunity against rubella using the serological status of rubella-specific IgG antibodies (antirubella IgG) in Korean women of childbearing age (15–49 years).DesignRetrospective cross-sectional study.SettingPopulation-based cross-sectional study in South Korea.ParticipantsBetween January 2010 and December 2017, test results from Korean women aged 15–49 years who had visited an obstetric private clinic (nationwide institutions) and had requested rubella-specific IgG antibody tests from Green Cross Laboratories were obtained from the laboratory information system.ResultsBetween 2010 and 2017, antirubella IgG test results from 328 426 Korean women aged 15–49 years who had visited private obstetric clinics (1438 institutions nationwide) were retrospectively analysed by tested year, age, cohort and geographic regions. Over the 8-year study period, the rate of unimmunised women ranged from 7.8% to 9.7%. Multivariable-adjusted logistic regression models showed that the odds of being immune to rubella (positive and equivocal results of antirubella IgG test) were lower in 2017 compared with 2010, in women in their 40s, in a pre-catch-up cohort and in women living in Incheon, Busan, South Gyeongsang, North and South Jeolla and Jeju provinces (p<0.0001).ConclusionsIn consideration of the factors associated with prevalence of women unimmunised to rubella, future public health efforts should be focused on catch-up activities. The results of this study could be used to strengthen disease control and prevent rubella, including a nationwide immunisation programme.

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Section: Discussionmentioning

confidence: 99%

Recent trends in seroprevalence of rubella in Korean women of childbearing age: a cross-sectional study

Choi¹,

et al. 2020

BMJ Open

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“…Since 2013, an average of 38 cases has been reported each year, reflecting changes in rubella epidemiology and outbreak patterns [22]. However, recent serological survey data for rubella in the Apulian population showed that a pocket of 13.3% persons aged 17-65 years still lack immunity against rubella [23].…”

Section: Epidemiology and Infection 595mentioning

confidence: 99%

Evaluation of measles and rubella integrated surveillance system in Apulia region, Italy, 3 years after its introduction

et al. 2018

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This study aimed at evaluating the integrated measles and rubella surveillance system (IMRSS) in Apulia region, Italy, from its introduction in 2013 to 30 June 2016. Measles and rubella case reports were extracted from IMRSS. We estimated system sensitivity at the level of case reporting, using the capture-recapture method for three data sources. Data quality was described as the completeness of variables and timeliness of notification as the median-time interval from symptoms onset to initial alert. The proportion of suspected cases with laboratory investigation, the rate of discarded cases and the origin of infection were also computed. A total of 127 measles and four rubella suspected cases were reported to IMRSS and 82 were laboratory confirmed. Focusing our analysis on measles, IMRSS sensitivity was 82% (95% CI: 75-87). Completeness was >98% for mandatory variables and 57% for 'genotyping'. The median-time interval from symptoms onset to initial alert was 4.5 days, with a timeliness of notification of 33% (41 cases reported ⩽48 h). The proportion of laboratory investigation was 87%. The rate of discarded cases was 0.1 per 100 000 inhabitants per year. The origin of infection was identified for 85% of cases. It is concluded that IMRSS provides good quality data and has good sensitivity; still efforts should be made to improve the completeness of laboratory-related variables, timeliness and to increase the rate of discarded cases.

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“…However, as already observed for other vaccinepreventable diseases, 18,19 the vaccination strategy based on the passive offer seems to be not enough for the achievement of the NPMCRE objective to reduce the percentage of susceptible females below 5%. 4,13 In conclusion, in Italy in 2017, the vaccine coverage for rubella in 16-years-old adolescents (born in 2001) is about 85% for the first dose and 83% for the second dose of MMR vaccine, 20 meaning that a considerable proportion of women entering to childbearing age are susceptible to rubella. It is therefore necessary to develop additional vaccination strategies that will target both Italian and recently immigrant women in order to reduce the pocket of susceptibility to rubella in young girls and WOCBA.…”

Section: Discussionmentioning

confidence: 99%

“…This value is higher than reported in a seroepidemiological study conducted in 2011-2012. 13 The higher proportion of samples with immunity to rubella is most likely due to vaccination campaign for MMR implemented within the framework of NPMCRE 2010-2015. The impact of that vaccination campaign in Apulia region was such that coverage for MMR increased from 87.7% for the first dose and 75.9% for the second dose in 18-years old subjects (born in 1998) to 92.5% and 82.7% respectively in 16-years-old subjects (born in 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, those WOCBA lacking protective immunity have probably missed vaccination offered by catch-up programmes. 13 Meanwhile, the concomitant decrease in the circulation of wild-type virus has reduced the possibility of natural infection-induced immunity. On the other hand, older women born in the 70s, during a high natural virus circulation period, show significantly higher antibody prevalence, possibly because of the higher antibody levels induced by natural infection.…”

Section: Discussionmentioning

confidence: 99%

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Elimination of congenital rubella: a seroprevalence study of pregnant women and women of childbearing age in Italy

Marchi

Viviani

Montomoli

et al. 2019

Human Vaccines & Immunotherapeutics

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Prevention of congenital rubella is achieved by vaccination of susceptible women of childbearing age. In Italy, the National Plan for Measles and Congenital Rubella Elimination 2010-2015 implemented catchup vaccination activities targeting susceptible adolescents and young adults, including women of childbearing age. The aim of this study was to assess the immunity against rubella in women of childbearing age in Tuscany (Central Italy) and Apulia (Southern Italy) and pregnant women in Apulia after the implementation of the National Plan for Measles and Congenital Rubella Elimination. Overall, anti-rubella IgG prevalence in women of childbearing age samples was 88.6% in Tuscany and 84.3% in Apulia. The lowest prevalence was observed in samples of 26-35 years old women of childbearing age in Apulia with 77.8%. Only 62.7% of samples from 26-35 years old pregnant women had IgG against rubella, and one sample out of 95 was positive to IgM. The findings of this study highlight the need for increasing awareness on the risk of contracting rubella infection during pregnancy and implement vaccination strategies to create opportunities for administration of rubella containing vaccines in young girls and women of childbearing age.

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Erratum to: lack of immunity against rubella among Italian young adults

Cited by 10 publications

References 1 publication

Recent trends in seroprevalence of rubella in Korean women of childbearing age: a cross-sectional study

Recent trends in seroprevalence of rubella in Korean women of childbearing age: a cross-sectional study

Evaluation of measles and rubella integrated surveillance system in Apulia region, Italy, 3 years after its introduction

Elimination of congenital rubella: a seroprevalence study of pregnant women and women of childbearing age in Italy

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