Erratum to: Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets

Olerud, Johan; Kanaykina, Nadegda; Vasylovska, Svitlana; King, Dennis L.; Sandberg, Monica; Jansson, Leif; Kozlova, Elena N.

doi:10.1007/s00125-009-1607-1

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“…In addition to their robust survival and broad differentiation potential, they display a remarkable ability to promote survival and support the function of different types of co‐cultured cells. Thus, bNCSCs stimulate proliferation of co‐cultured (Grouwels et al, ; Ngamjariyawat, Turpaev, Vasylovska, Kozlova, & Welsh, ; Ngamjariyawat, Turpaev, Welsh, & Kozlova, ; Wang et al, ) and co‐implanted insulin‐producing pancreatic beta‐cells (Lau, Vasylovska, Kozlova, & Carlsson, ; Olerud et al, ). Co‐transplantation of bNCSCs and human pancreatic islets increased islet vascularization and innervation, most likely mediated by diffusible factors released from the bNCSCs (Grapensparr et al, ; Lau et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of scaffold properties on adhesion and maintenance of boundary cap neural crest stem cells in vitro

Han

Baltriukienė

Kozlova

2020

J Biomedical Materials Res

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Optimal combination of stem cells and biocompatible support material is a promising strategy for successful tissue engineering. The required differentiation of stem cells is crucial for functionality of engineered tissues and can be regulated by chemical and physical cues. Here we examined how boundary cap neural crest stem cells (bNCSCs) are affected when cultured in the same medium, but on collagen‐ or laminin‐polyacrylamide (PAA) scaffolds of different stiffness (0.5, 1, or ~7 kPa). bNCSCs displayed marked differences in their ability to attach, maintain a large cell population and differentiate, depending on scaffold stiffness. These findings show that the design of physical cues is an important parameter to achieve optimal stem cell properties for tissue repair and engineering.

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