Erratum to: Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study

Krille, Lucian; Dreger, Steffen; Schindel, R.; Albrecht, Thomas; Asmussen, M.; Barkhausen, Jörg; Berthold, J. D.; Chavan, A.; Claussen, Claus D.; Forsting, Michael; Gianicolo, Emilio; Jablonka, Karsten; Jahnen, Andréas; Langer, Mathias; Laniado, Michael; Lotz, Joachim; Mentzel, HJ; Queißer-Wahrendorf, Annette; Rompel, Oliver; Schlick, J.; Schneider, K.; Schumacher, Martin; Seidenbusch, Michael; Spix, Claudia; Spors, Birgit; Staatz, Gundula; Vogl, Thomas J.; Wagner, Joachim; Weisser, G; Zeeb, Hajo; Blettner, Maria

doi:10.1007/s00411-017-0694-5

Cited by 63 publications

(10 citation statements)

References 3 publications

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“…After excluding patients at increased risk of cancer, SIR figures were reduced to 1.54 for all cancers (95%: CI 1.05, 2.19), 1.79 for leukaemia (95% CI 0.92, 3.12) and 1.85 for lymphoma (95% CI 0.68, 4.02). The impact of this change on lymphoma SIR was much smaller than found in the current study, although Krille et al [ 27 , 28 ] did not have the benefit of transplant registry linkage. Mean cumulative bone marrow doses (11.7 mGy) were a little higher than in the current study (8.8 mGy).…”

Section: Comparison With Previous Studiescontrasting

confidence: 84%

“…Our SIR for leukaemia was higher, though statistically compatible with that of Hammer et al [ 26 ]. Focussing only on CT scans, Krille et al [ 27 , 28 ] reported raised SIRs for all cancers (1.82, 95% CI 1.29, 2.50), lymphoma (2.96, 95% CI 1.42, 5.45) and leukaemia (1.72, 95% CI 0.89, 3.01). After excluding patients at increased risk of cancer, SIR figures were reduced to 1.54 for all cancers (95%: CI 1.05, 2.19), 1.79 for leukaemia (95% CI 0.92, 3.12) and 1.85 for lymphoma (95% CI 0.68, 4.02).…”

Section: Comparison With Previous Studiesmentioning

confidence: 99%

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Cancer incidence among children and young adults who have undergone x-ray guided cardiac catheterization procedures

et al. 2018

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Children and young adults with heart disease appear to be at increased risk of developing cancer, although the reasons for this are unclear. A cohort of 11,270 individuals, who underwent cardiac catheterizations while aged ≤ 22 years in the UK, was established from hospital records. Radiation doses from cardiac catheterizations and CT scans were estimated. The cohort was matched with the NHS Central Register and NHS Transplant Registry to determine cancer incidence and transplantation status. Standardized incidence ratios (SIR) with associated confidence intervals (CI) were calculated. The excess relative risk (ERR) of lymphohaematopoietic neoplasia was also calculated using Poisson regression. The SIR was raised for all malignancies (2.32, 95% CI 1.65, 3.17), lymphoma (8.34, 95% CI 5.22, 12.61) and leukaemia (2.11, 95% CI 0.82, 4.42). After censoring transplant recipients, post-transplant, the SIR was reduced to 0.90 (95% CI 0.49, 1.49) for all malignancies. All lymphomas developed post-transplant. The SIR for all malignancies developing 5 years from the first cardiac catheterization (2 years for leukaemia/lymphoma) remained raised (3.01, 95% CI 2.09, 4.19) but was again reduced after censoring transplant recipients (0.98, 95% CI 0.48, 1.77). The ERR per mGy bone marrow dose for lymphohaematopoietic neoplasia was reduced from 0.541 (95% CI 0.104, 1.807) to 0.018 (95% CI − 0.002, 0.096) where transplantation status was accounted for as a time-dependent background risk factor. In conclusion, transplantation appears to be a large contributor to elevated cancer rates in this patient group. This is likely to be mainly due to associated immunosuppression, however, radiation exposure may also be a contributing factor.

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Section: Comparison With Previous Studiescontrasting

confidence: 84%

Section: Comparison With Previous Studiesmentioning

confidence: 99%

Cancer incidence among children and young adults who have undergone x-ray guided cardiac catheterization procedures

et al. 2018

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“…30 CT and CC procedures both deliver X-ray radiation. Recent studies reported radiation doses delivered by CT ranging from 8 to 12 milliGray (mGy) to the red Open access bone marrow, [31][32][33][34] a range of doses consistent to the mean dose of 8.8 mGy to the red bone marrow reported from a recent CC study. 22 As cumulative doses due to CT in childhood are in the range of those delivered by CC procedures, the estimated SIRs in our cohort can be compared with those from recently published CT studies.…”

Section: Main Findingssupporting

confidence: 53%

“…22 As cumulative doses due to CT in childhood are in the range of those delivered by CC procedures, the estimated SIRs in our cohort can be compared with those from recently published CT studies. [32][33][34][35] CHD patients usually require ongoing care to monitor their condition that may result in repeated exposure to LDIR 3 5 7-9 and may lead to hig h cumulative doses. In the current study, the cumulative number of procedure received (1, 2 and ≥3 procedures) is used as a surrogate to Open access the cumulative individual doses.…”

Section: Main Findingsmentioning

confidence: 99%

Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile

et al. 2021

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PurposeThe COCCINELLE study is a nationwide retrospective French cohort set up to evaluate the risk of cancer in patients who undergone cardiac catheterisation (CC) procedures for diagnosis or treatment of congenital heart disease during childhood.ParticipantsChildren who undergone CC procedures from 1 January 2000 to 31 December 2013, before the age of 16 in one of the 15 paediatric cardiology departments which perform paediatric CC in mainland France were included. The follow-up started at the date of the first recorded CC procedure until the exit date, that is, the date of death, the date of first cancer diagnosis, the date of the 18th birthday or the 31 December 2015, whichever occurred first. The cohort was linked to the National Childhood Cancer Registry to identify patients diagnosed with cancer and with the French National Directory for the Identification of Natural Persons to retrieve the patients’ vital status.Findings to dateA total of 17 104 children were included in the cohort and followed for 110 335 person-years, with 22 227 CC procedures collected. Among the patients, 81.6% received only one procedure. Fifty-nine cancer cases were observed in the cohort. Standardised incidence ratios (SIRs) were increased for all-cancer (SIR=3.8, 95% CI: 2.9 to 4.9), leukaemia (SIR=3.3, 95% CI: 2.0 to 5.4), lymphoma (SIR=14.9, 95% CI: 9.9 to 22.5) and solid cancers excluding central nervous system (CNS) tumours (SIR=3.3, 95% CI: 2.0 to 5.5) compared with the general population.Future plansDose reconstruction is currently underway to estimate individual cumulative doses absorbed to relevant organs, including red bone marrow and brain for respectively haematologic disorders and CNS tumours risk estimation. A dose–response analysis will be conducted with consideration to confounding factors such as age at exposure, gender, predisposing factors to cancer and other sources of medical diagnostic low-dose ionising radiation.

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“…Of the remaining 382 records, 7 full-text studies met all of the inclusion criteria. 13,14,[15][16][17][18][19] Of the studies excluded from the 382 records, 201 were conference abstracts lacking full text, or case reports, 65 did not report original research, 51 did not provide comparative data, 25 were repeat publications, and 30 were nonhuman studies ( Figure 1). All 7 included studies were retrospective cohort studies.…”

Section: Literature Search and Characteristics Of Included Studiesmentioning

confidence: 99%

Radiation Exposure Associated With Computed Tomography in Childhood and the Subsequent Risk of Cancer: A Meta-Analysis of Cohort Studies

Huang

Liu

et al. 2020

Dose-Response

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Background: Computed tomography (CT) is used worldwide; however, recent studies suggest that CT radiation exposure during childhood may be a risk factor for cancer, although the data are inconsistent. Methods: A comprehensive search of electronic databases including PubMed, SpringerLink, Embase, Cochrane Library, Elsevier/ScienceDirect, Medline, Orbis, and Web of Science databases from January 1990 to November 2018 for observational epidemiologic studies reporting associations between radiation exposure from CT in childhood and the subsequent risk of cancer was conducted. A linear model was used to explore the dose–response relationship. Results: Seven studies with 1180 987 children enrolled were included. The risk of later cancer was 1.32-fold higher for children exposed to CT than those without exposure. Compared to those not exposed to pediatric CT, the relative risk (RRs) were larger for the higher doses but with wider CIs (RR for 5-10 mGy: 0.90, 95% CI: 0.69-1.12; RR for 10-15 mGy: 1.02, 95% CI: 0.86-1.18; RR for >15 mGy: 1.13, 95% CI: 0.97-1.30), the leukemia risk was higher in exposed children (RR: 1.23, 95% CI: 1.10-1.36), and brain cancer risk was higher in exposed children (RR: 1.54, 95% CI: 0.84-2.45). Conclusions: Our analysis suggested that radiation exposure from CT during childhood is associated with a subsequently elevated risk of cancer. However, caution is needed when interpreting these results because of the heterogeneity among the studies. The findings should be confirmed in further studies with longer follow-up periods.

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Erratum to: Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study

Cited by 63 publications

References 3 publications

Cancer incidence among children and young adults who have undergone x-ray guided cardiac catheterization procedures

Cancer incidence among children and young adults who have undergone x-ray guided cardiac catheterization procedures

Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile

Radiation Exposure Associated With Computed Tomography in Childhood and the Subsequent Risk of Cancer: A Meta-Analysis of Cohort Studies

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