Erroneous data on renal hemodynamics derived from DCE‐MRI in rats

Cantow, Kathleen; Flemming, Bert; Seeliger, Erdmann

doi:10.1002/jmri.25584

Cited by 1 publication

(2 citation statements)

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“…13,14 Renal MRI is noninvasive, affords full kidney coverage, excellent soft tissue contrast, high temporal resolution, and longitudinal studies without ionizing radiation, 15,16 as illustrated by Figure 1 showing multi-parametric MRI for probing different physiological parameters at different spatial scales using T 1 , T 2 , T 2 *, blood oxygenation level dependent, apparent water diffusion and renal blood volume contrast. 17,18 To address this issue parametric MRI needs to be calibrated with quantitative gold standard methods. 15 Quantitative data on functional renal parameters obtained by MRI, without proper calibration, may be erroneous and their interpretation is questionable.…”

Section: Validation With Quantitative Physiological Measurementsmentioning

confidence: 99%

“…15 Quantitative data on functional renal parameters obtained by MRI, without proper calibration, may be erroneous and their interpretation is questionable. 17,18 To address this issue parametric MRI needs to be calibrated with quantitative gold standard methods. With regard to renal oxygenation, calibration is on its way: By means of an integrated multi-modality approach designated as MR-PHYSIOL the simultaneous tracking of invasive physiological parameters and the oxygenation-sensitized MR parameter T 2 * was demonstrated in the same kidney of rats in vivo.…”

Section: Validation With Quantitative Physiological Measurementsmentioning

confidence: 99%

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kidneys: A) photograph of freshly excised kidney, B) T 1 -weighted anatomical MR microscopy acquired ex vivo using an in-plane spatial resolution of 50 μm (cortex COR; outer medulla OM; inner medulla IM), C) T 2 * sensitized MR image acquired ex vivo using an in-plane spatial resolution of 50 μm, D) Mesoscopic in vivo parametric map of the MRI relaxation time T 2 which represents the blood oxygenation level at the more capillary level (in-plane spatial resolution 300 μm), E) In vivo map of the MRI relaxation parameter T 2 * (in-plane spatial resolution of 300 μm) which is a surrogate for blood oxygenation of large venous vessels, F) Apparent water diffusion coefficient (ADC) map with a spatial resolution of 300 μm showing Brownian water motion at the scale of 50 μm, G) In vivo map of renal cortical and outer medullary renal blood volume fraction (BVf) obtained from T 2 * mapping using an intravascular contrast agent (4 mg Fe/kg USPIO). The 1 cm scale bar illustrates the size of the rat kidney. MRI, magnetic resonance imaging | 5 of 5 EXACTA Centre for Cardiovascular Research, BER 6.1, partner site Berlin) and by the Federal Ministry

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