Erroneously High Troponin Caused by Fibrin Clot: Two Cases

Yavuz, Hatice Bozkurt

doi:10.14744/ijmb.2021.64872

Cited by 1 publication

(1 citation statement)

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“…In some of our previous studies, we have investigated the effects of fibrin clots in serum on troponin measurements, which is obtained by immunoassay methods such as the hCG test ( 16 , 17 ). Fibrin clots can lead to erroneous measurements due to insufficient sample volume, sample probe clogging, and assay interference ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Fibrin clot interference in a human chorionic gonadotrophin assay causing a false Down syndrome screening result

Akagac¹,

Yavuz²

2023

Biochem. med. (Online)

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Serum samples are generally used for the measurement of human chorionic gonadotrophin (hCG) to calculate second-trimester maternal screening results. Lower hCG concentrations correlate with a lower calculated risk of Down syndrome (DS). Hence, erroneously low hCG results due to fibrin clot may lead to misinterpretation. We present a 23-year-old woman with a pregnancy of 17+3 weeks. Blood was taken into the Becton-Dickinson (BD) vacutainer SST-II Advance tube (Ref: 367955). The hCG test was performed on Immulite 2000 XPi analyser (Siemens Healthcare Diagnostics Inc, Tarrytown, USA) with original reagents. The results of the same sample were found as 2566 U/L, 18,153 U/L, and 7748 U/L. Three consecutive results after removal of the small fibrin clot and recentrifugation were 18,878, 20,255, and 22,339 U/L. The risk of DS and MoM for the concentration of 2556 U/L hCG was < 1/10,000 and 0.14, respectively. For a hCG concentration of 20,255 U/L, these values were 1/5632 and 1.13, respectively. Laboratory professionals and technicians should be aware that erroneously low hCG results can be measured with the Immulite 2000 XPi due to interference from small fibrin clots. Falsely underestimated hCG values reduce the MoM values and thus the calculated risk of DS.

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Section: Discussionmentioning

confidence: 99%