Relevance: A key aspect of success after dental implant surgery is obtaining reliable osseointegration of the installed dental implant. In modern literary sources, the problem of consistency of osseointegration after the installation of dental implants is quite often touched upon. A number of authors argue that the quality of osseointegration of a dental implant depends primarily on its primary stability. Long-term studies show that bone tissue permanently undergoes various resorption and recovery processes [1, 2]. Purpose to determine the effectiveness of alkaline phosphatase and collagen protein osteocalcin in oral fluid after dental implantation. Materials and methods: Clinical studies were carried out on the basis of the Clinics of the Samara State Medical University of the Ministry of Health of Russia. A total of 240 patients with a diagnosis of partial absence of teeth were operated on. All patients received dental implants. The median age was 44.2 years (24 to 62 years; 182 women and 58 men). Results and discussion: At the stage of orthopedic rehabilitation, most patients had a low index of oral hygiene, OHI-S averaged (2.63 0.27) c.u. All patients suffering from poor oral hygiene were recommended professional hygiene with the removal of soft and hard dental deposits. At the stage of dental implantation, the OHI-S and Mulleman index was (0.66 0.03) and (0.49 0.03) c.u. respectively. Conclusions: The results of the study showed that the increase in the titer of alkaline phosphatase and the collagen protein osteocalcin was statistically insignificant. The level of acid phosphatase titer in the oral fluid reaches its critical value two weeks after the dental implantation operation. Studies have shown that this indicator remains active up to six months after surgery. This indicator can be used to interpret various emerging trophic processes occurring in bone tissue after dental implantation.