This work was partially funded by the European Union in the context of the Next-Lab innovation action (Grant Agreement 731685) under the Industrial Leadership -Leadership in enabling and industrial technologies -Information and Communication Technologies (ICT) theme of the H2020 Framework Program. This thesis does not represent the opinion of the European Union, and the European Union is not responsible for any use that might be made of its content.My fellow-PhDs, how many different roles you played: a psychological support group, helpful reviewers, companions in laugh, and so many other. Thank you very much for travelling along; for sharing; for making the road look manageable. Xiulin, it was great to be your roomie, your hard work encouraged me and your readiness to help meant a lot to me. My great paranymphs -Elise and Johannes -thank you for helping with more and less serious choices; for discussing my statistical or/and philosophical questions; and simply for being there for me. My work would not have been completed if I had not felt loved, supported, appreciated, encouraged and believed in. My dear husband, Martin, your faith in me makes me stronger and your care allows me to act. Ik ben zo gelukkig met en zo dankbaar voor alle (schoon-)familie en vrienden die ik hier heb ontmoet voor hun steun, zorg en begrip. Jullie hebben me hier thuis laten voelen en het hielp enorm.And the last but definitely not the least, I would like to thank my family and friends in Russia.
Natasha iiiTABLE OF CONTENTS Chapter