A gronomy J our n al • Volu me 10 0 , I s sue 4 • 2 0 0 8 ABSTRACT Economic or environmental benefi ts resulting from variable-rate (VR) application of N and seed are uncertain in irrigated maize (Zea mays L.) systems with high yield potential. We evaluated diff erent plant population and N management strategies in two irrigated maize fi elds in Nebraska. Inputs were varied according to yield zones derived from yield maps, detailed maps of soil organic matter (SOM), and sampled seasonal NO 3 status. Uniform management following Best Management Practices (BMPs) resulted in high levels of grain yield (>15 t ha −1 at Site 1; >12 t ha −1 at Site 2), nitrogen use effi ciency (NUE), and gross return above input cost. Management of high-yielding irrigated systems on relatively fl at terrain was not improved through the predictive site-specifi c approaches tested in this study, which relied on available historical fi eld information (yield maps, weather) and seasonal soil sampling. Among four site-years, only one site-year showed signifi cant increases in yield and NUE and decrease in N input with the VR N. Yield interactions between VR N management strategies and plant population were not signifi cant. More potential for increasing yields, resource effi ciency, and profi tability may exist through integrating such approaches with dynamic, in-season management of water and N. Such approaches are emerging, but remain to be evaluated thoroughly, particularly under high-yielding conditions and against conventional BMPs.