Erste effiziente Hydroaminomethylierung mit Ammoniak: mit dualen Metallkatalysatoren und Zweiphasenkatalyse zu primären Aminen

Operando Spectroscopy in Catalytic Carbonylation Reactions

“…The major product aldehyde is often not the target for applications as they are usually further oxidized, reduced, or coupled to form added-value products. With this in mind, many cascade reactions were developed, including hydroformylation-hydrogenation, − hydroformylation-cyclization, − isomerization-hydroformylation, − hydroformylation-acetalization, , and the well-known hydroaminomethylation (HAM), − the latter consisting of a cascade hydroformylation-reductive amination. The full mechanism of the HAM reaction has not been proven yet, and the real active species have not been unambiguously identified.…”

“…The full mechanism of the HAM reaction has not been proven yet, and the real active species have not been unambiguously identified. It is even suspected that two different active species accounting for each reaction sequence are present in solution . Van Leeuwen, Beller, and co-workers reported in 2006 an in situ study in order to determine reaction pathways or some reaction intermediates .…”