Erupção acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla

Abstract

Abstract:Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomodulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an acneiform eruption resulting from treatment with interferon beta-1b. Keywords: Acneiform eruptions; Interferon-beta; Multiple sclerosis; Therapeutics Resumo: Esclerose múltipla é uma doença inflamatória desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapêutica é baseada no uso de imunomoduladores, como o interferon beta, que são geralmente bem tolerados. As manifestações cutâneas secundárias ao interferon beta-1b são representadas, na maioria das vezes, por reações no local de sua aplicação subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupção acneiforme pelo interferon beta-1b.

A Case Report on Steroid Induced Acneiform Eruptions

“…One which caused by systemic drugs is dependent on the dose, duration of administration and patients susceptibility. 6 Systemic drugs that induced acneiform eruptions include corticosteroids, epidermal growth factor receptor inhibitors, cyclosporine, anticonvulsants, antipsychotics, antidepressants, tumor necrosis factor-alpha inhibitor, anabolic steroids, danazole, anti-tuberculosis drugs, quinidine, azathioprine and testosterone. 3 Acneiform eruptions are non-allergic reactions, in most cases the exact etiology and pathogenesis remains unknown.…”

Drug-induced acne and rose pearl: similarities

“…1,2 Usually, topical products such as cosmetics may lead to acneiform eruption in women, especially in the region of the chin. 2 Intravenous dexamethasone and high doses of oral corticosteroids often induce typical acneiform eruptions, with lesions predominantly located on the chest and back. 1 …”

“…1,2,3 Punctiform vesicles occasionally appear in the center of papules, which may develop into small vesicopustules. 2,3 An important clinical aspect in the differential diagnosis of drug-induced acne is the fact that the skin lesions are not preceded by visible comedones. 4 …”

“…Antihistamines are recommended in case of pruritus, and oral antibiotics are recommended in case of secondary infection with pustules or impetiginization. 2,3 …”