Eruptive poromatosis in a patient with breast cancer

Abstract

Poromas are a group of benign growths of poroid differentiation derived from cells of the terminal sweat duct and connected to the epidermis, normally presenting as solitary papules, plaques or nodules. Rarely they can be eruptive in nature and as such are described as poromatosis. We report an unusual case of widespread poromatosis occurring in a woman with metastatic breast cancer who had recently completed chemo-radiotherapy.

YAP1::MAML2 fusions in poromatosis: A report of two patients

“…Letrozole is an aromatase inhibitor that blocks the conversion of androgens into estrogens. A previous report has described the occurrence of poromatosis in a 63‐year‐old woman with a history of breast cancer 8 . The patient underwent completion mastectomy and received fluorouracil–epirubicin–cyclophosphamide chemotherapy plus letrozole 8 .…”

“…Patients often received treatments, such as transplantation and chemotherapy, sometimes with radiotherapy 3–7 . Some patients had been treated for breast cancer 8,12 or stomach cancer 9 with chemotherapy. One patient with poromatosis had systemic lupus erythematosus and received immunosuppressants, including prednisolone, mizoribine, and tacrolimus 13 .…”

“…Poromas typically occur as solitary papules or nodules on the sole or palm but can be found anywhere on the skin 2 . Multiple poromas (i.e., poromatosis) occur rarely, mainly in patients with hematopoietic or visceral malignancies 3–9 . Patients often have a history of treatments such as transplantation, chemotherapy, and radiotherapy, suggesting an association between poromatosis and immunosuppressive treatment 3–9 .…”

“…Multiple poromas (i.e., poromatosis) occur rarely, mainly in patients with hematopoietic or visceral malignancies 3–9 . Patients often have a history of treatments such as transplantation, chemotherapy, and radiotherapy, suggesting an association between poromatosis and immunosuppressive treatment 3–9 . The onset of poromatosis in a pregnant woman 10 and in a breast cancer patient treated with endocrine therapy 8 have indicated an association between hormonal changes and poromatosis.…”

Eccrine poromatosis following chemotherapy and radiation therapy

“…Chemotherapy or radiation therapy may be the most likely etiology for eccrine poromatosis. That is, a history of chemotherapy and/or radiation therapy is often noted in eccrine poromatosis cases (Table 1), [2,3,[5][6][7][8][9][10][11][12][13][14][15][16][17]. Although it is common for patients to receive both chemotherapy and radiation therapy throughout the course of their neoplastic treatment, eccrine poromatosis most commonly occurs on nonirradiated skin in patients who received polychemotherapy [2].…”