Erythema multiforme‐like generalized contact dermatitis to l‐menthol contained in anti‐inflammatory medical compresses as an ingredient

Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic

“…In pharmaceutical products, it is used far more often and in higher concentrations for the treatment of itch and itching dermatoses. In spite of this, only sporadic cases of contact allergy have been reported , often in combination with allergy to Mentha piperita (peppermint) oil, which contains 35–60% menthol . The infrequency of contact allergy to menthol was also shown in a recent study by the Information Network of Departments of Dermatology: of 1147 dermatitis patients tested with menthol between 2005 and 2008, only 1 (0.09%) had a positive reaction .…”

Review of Allergic and Photoallergic Contact Dermatitis from an Ingredient in a Medicament Vehicle Consisting of a Compress, Poultice, Plaster, and Tape

“…Additives, such as crotamiton [6], diisopropanolamine [6, 10, 15], l-menthol [12, 14], paraben [7], and modified resin [11, 12] also have been shown to be allergens. Benzalkonium chloride usually induces irritant contact dermatitis, but rarely induces allergic contact dermatitis [5, 16–18].…”

“…Some cases may show a rectangular eruption with a diffuse erythematous [6] or erythema multiform-like generalized reaction [14]. Case 2 was an 87-year-old Japanese male with a rectangular erythema on the bilateral lower back and the buttock and a diffuse erythema on the trunk and extremities caused by allergic contact dermatitis from the diisopropanolamine in the compresses that he used (Figure 3) [15].…”

l-Menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammationvianuclear factor kappa B, p38 MAPK and Nrf2 signalling pathways

“…Since ancient times, Mentha species have been used in traditional medicines due to their antispasmodic and carminative properties. 8 Recently, more attention has been paid on the pharmacological effects of their active constituents, such as l -menthol, which is the main component of essential oil of from Mentha species. 9 Several studies demonstrated that l -menthol has diverted various pharmacological properties including analgesic, 10 antibacterial, 11 antitussive, 12,13 immune modulator, 14 anti-apoptotic, 15 antimicrobial 16 and antifungal activities, 17 especially its significant anti-inflammatory 8,14,18,19 and antioxidative effects.…”

“…8 Recently, more attention has been paid on the pharmacological effects of their active constituents, such as L-menthol, which is the main component of essential oil of from Mentha species. 9 Several studies demonstrated that L-menthol has diverted various pharmacological properties including analgesic, 10 antibacterial, 11 antitussive, 12,13 immune modulator, 14 anti-apoptotic, 15 antimicrobial 16 and antifungal activities, 17 especially its signicant anti-inammatory 8,14,18,19 and antioxidative effects. 16 Moreover, L-menthol was identied as the main ingredient in many compound preparations which are clinically effective in several respiratory diseases such as bronchitis, allergic rhinitis, laryngopharyngitis and sinusitis in China.…”