Erythema nodosum

Blomgren, Stephen E.

doi:10.1016/0049-0172(74)90015-8

Cited by 19 publications

(3 citation statements)

References 59 publications

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“…EN has been associated with a heterogeneous group of systemic diseases such as sarcoidosis, inflammatory bowel disease, Behçet's disease, or connective tissue diseases (13)(14)(15)(16)(17). Infections have also been implicated in the development of this condition, mainly primary tuberculosis (3,5), Streptococcus ␤ haemolyticus (18,19), Yersinia, Salmonella, and Campylobacter (20)(21)(22)(23)(24)(25)(26), and, less frequently, others such as brucellosis (27), toxoplasmosis (28), blastomycosis (29), histoplasmosis (30), primary coccidioidomycosis (2,5), syphilis (31), leprosy (1), invasive amebiasis and giardiasis (32), hepatitis B virus (33), infectious mononucleosis (34), cytomegalovirus (35), and Mycoplasma (36).…”

Section: Discussionmentioning

confidence: 99%

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Erythema nodosum: Etiologic and predictive factors in a defined population

Garcı́a-Porrúa

González-Gay

Vázquez‐Caruncho

et al. 2000

Arthritis & Rheumatism

129

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Section: Discussionmentioning

confidence: 99%

“…Also, in these cases, treatment of the malignancy should have led to resolution of the EN. 13. Relapse: if a patient previously diagnosed with EN and asymptomatic for at least 1 month presented again with a new flare of lesions.…”

mentioning

confidence: 99%

Erythema nodosum: Etiologic and predictive factors in a defined population

Garcı́a-Porrúa

González-Gay

Vázquez‐Caruncho

et al. 2000

Arthritis & Rheumatism

129

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“…More recently the oral aromatic retinoid analogue of vitamin A (Ro-10-9359: Tigason) has been used for the same conditions, with good results (2)(3)(4). A limiting factor regarding the therapeutic use of re tinoids is the frequency of side effects, most often cheilitis, mucosal dryness, exfoliation of palms and soles, pruritus, sweating, alopecia and severe !iver damage, as well as general malaise, dizziness, nausea, etc.…”

Section: Received October 14 1981mentioning

confidence: 99%

Suppression of erythema nodosum by indomethacin

Ubogy,

Persellin

1982

Acta Derm Venereol

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Erythema nodosum (EN) can be a debilitating illness. Many treatment modalities have been suggested but none is universally effective. We describe three patients with severe EN secondary to streptococcal pharyngitis who were unresponsive to large doses of aspirin. Following the administration of indomethacin in doses of 100 to 150 mg per day, all three showed a dramatic response, with prompt resolution both of systemic symptoms and of local signs of inflammation. The lesions of EN involve the lower cutis, with inflammation of septae and fat lobules. It is likely, therefore, that the local liberation of fatty acids leads to increased prostaglandin synthesis which, in turn, is responsible for the intense inflammation. The impressive suppression of EN by indomethacin could be related to the inhibition of prostaglandin synthetase in the subcutaneous fatty tissues.

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Familial Erythema Nodosum

Elkayam

Caspi²,

Segal³

et al. 1991

Arthritis & Rheumatism

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Erythema nodosum (EN) is a hypersensitivity reaction associated with many diseases. We describe a family in which 4 sisters had acute or recurrent EN. HLA typing showed a common haplotype in the affected members of the family. A review of familial EN and HLA distribution in EN is presented.Erythema nodosum (EN) is considered to be an acute hypersensitivity reaction. It may occur alone or in association with various other diseases or certain medications (1,2). There have been a few reports of familial EN, mostly occurring during tuberculosis (TB) infection (3). We recently studied a family in which all 4 sisters developed EN after pharyngitis. In 3 of them, EN was recurrent. The family, which was studied following examination of 1 of our patients (AP), who presented with acute EN, is discussed herein. Case reports. Sister 1 (AP), 41 years old, was admitted to the hospital because of fever, painful lesions in both legs, and arthralgia of the ankles and knees. A month earlier she had had pharyngitis, which was treated with amoxicillin. On examination, her temperature was 38"C, and she had several raised, red, tender nodular lesions on the pretibial region and tenderness on movement of the ankles and knees, without clear-cut synovitis. The rest of the physical examination findings were unremarkable. Laboratory studies showed an erythrocyte sedimentation rate of 45 mm/hour, and normal results of a complete blood cell count, measurements of glucose, urea, sodium, and potassium, and liver and kidney function tests. Antinuclear antibodies and rheumatoid factor were negative. The antistreptolysin 0 (ASO) titer was high (800 Todd units). A throat culture was negative, but a tuberculin test with 1/10,000 old tuberculin solution gave a strongly positive result: Radiography showed an old apical primary complex and calcified hilar adenopathy . Sputum culture was negative for Koch's bacillus.The patient was treated with naproxen, with complete resolution of her symptoms within 2 weeks. She did not recall having similar episodes in the past, but mentioned that her 3 sisters had similar symptoms on a recurrent basis.Sister 2 (SB), 54 years old, reported having had 4 episodes of EN. The first occurred when she was 26 years old. A few days after a sore throat, she noticed painful red spots on both legs and knees. She also had severe arthralgia of the ankles, knees, wrists, and shoulders. A skin biopsy confirmed the diagnosis of EN. The symptoms resolved upon treatment with aspirin. During the next 15 years, she had 3 more

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Erythema nodosum

Cited by 19 publications

References 59 publications

Erythema nodosum: Etiologic and predictive factors in a defined population

Erythema nodosum: Etiologic and predictive factors in a defined population

Suppression of erythema nodosum by indomethacin

Familial Erythema Nodosum

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