Erythrina Alkaloids

Chawla, Amit Kumar; Kapoor, Vijay K.

doi:10.1016/b978-0-08-042089-9.50010-3

Cited by 17 publications

(11 citation statements)

References 178 publications

(291 reference statements)

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“…In traditional medicine, the genus has been prominently used in folk medicine (Tanaka et al, 1999;Chawla and Kapoor, 1995), especially for the treatment of microbial infections (Mitscher et al, 1987). The seeds of at least one-third of the species contain potent erythrina alkaloids, and some of these are used for medicinal and other purposes by indigenous peoples.…”

Section: Introductionmentioning

confidence: 99%

In vitro pharmacological activity of the crude acetone extract of Erythrina caffra Thunb: antibacterial and antifungal assessment

Olajuyigbe¹

2012

J. Med. Plants Res.

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The antimicrobial activity of stem bark acetone extract of Erythrina caffra Thunb. against medically important pathogens was evaluated by determining the inhibition zones and the minimum inhibitory concentrations (MICs) of the extract. The result showed that the extract had good antimicrobial activity against the tested bacterial and fungal isolates with the increases in the inhibition zones being concentration dependent. The degree of the antibacterial activity indicated that the minimum inhibitory concentration (MIC) values ranged between 0.0195 and 1.25 mg/ml while the minimum bactericidal concentrations (MBC) ranged between 0.0391 and 1.25 mg/ml for the extract. The extract was less potent than the standard antibiotic, ciprofloxacin, having MIC values of (0.0195 to 0.625 µg/ml). For the fungal isolates, the MIC and minimum fungicidal concentration (MFC) values ranged between 0.625 and 20 mg/ml. Though the results showed that the bacteria were more susceptible to the extract than the fungi, the extract inhibited Gram-negative bacteria more than the Gram-positive bacteria at low concentrations. This study shows a broad spectrum and great therapeutic potential of the plant with the ability to attract significant scientific attention.

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Section: Introductionmentioning

confidence: 99%

In vitro pharmacological activity of the crude acetone extract of Erythrina caffra Thunb: antibacterial and antifungal assessment

Olajuyigbe¹

2012

J. Med. Plants Res.

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“…Melanacanthine 58 inhibits thrombocyte agglutination and can be used in the treatment of hypertonia. The erythrina alkaloids 57 – 58 exhibited paralyzing activity [ 70 , 74 ].…”

Section: Naturally Occurring Naphthyridine Derivativesmentioning

confidence: 99%

Biological Activity of Naturally Derived Naphthyridines

2021

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Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes.

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“…KRUKOFF (1939) recognized, however, that some authorities still considered the two species to be synonymous (NEILL 1993) and recommended further chemotaxonomic studies in order to sustain and to delimit the species. SOTO-HERNANDEZ & JACKSON (1994), CHAWLA & KAPOOR (1995) and GARCIA-MATEOS et al (1996, 1998 studied seeds, leaves, flowers, and bark of mature individuals of both species in order to identify the alkaloids in each organ. It was determined that seeds of E. coralloides contain erythraline, erysothramidine and erysonine, whilst these alkaloids are absent in seeds of E. americana (GARCIA-MATEOS et al 2001).…”

Section: Introductionmentioning

confidence: 98%