Erythro-hentriacontane-6,8-diol and 11 other alkane-6,8-diols from Carthamus tinctorius

Inhibitory Effect of Alkane-6,8-Diols, the Components of Safflower, on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin

“…Quercetin was isolated from sophorae flos in our laboratory. The fraction of erythro-alkane-6,8-diols separated from carthami flos contained C21 (2.6%), C23 (1.3%), C25 (0.9%), C27 (8.3%), C29 (7.3%), C30 (2.8%), C3, (28.6%), C32 (4.3%), C33 (14.5%), C34 (2.0%), and C35 (2.4%) diols, and 25.0% unidentified components [14]. Individual alkane diols used in this study were isolated from the fraction [14],…”

“…From this active fraction, A5-and A7-sterols were separated. In addition, erythro-alkane-6,8-diols from one active fraction o f carthami flos were isolated and charac terized [ 14]. In this study we examined the anti-inflam matory effect o f these erythro-alkane-6,8-diols against TPA-induced inflammation, and found these compounds to possess a marked inhibitory effect.…”

Inhibitory Effect of Taraxastane-Type Triterpenes on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin

“…Recent ly, it was reported that faradiol (taraxast-20-ene-3p,16p-diol), a taraxastane-type triterpene, from the flowers of Calendula officinalis (Compositae) exhibited marked anti-inflammatory activity on the croton oil-induced der matitis of the mouse ear [10,11]. In addition to our research of Compositae plants [12][13][14][15][16], we have demon strated that the chemical and pharmacological studies of sterols, triterpenes and alkane-6,8-diols from the flowers of Carthamus tinctrius exhibited considerable activity against TPA-induced inflammation and tumor promo tion. Taraxastane-type triperpenes are isolated from the flowers of some Compositae plants, the separation was examined for inhibitory activity against TPA-induced inflammation in mice [unpubl.…”

Separation and determination of chalcones fromCarthamus tinctorius L. and its medicinal preparation by capillary zone electrophoresis

“…The chemical constituents from this plant have been examined, and the isolation of flavonoids [2,3], polyacetylenes [4], serotonin derivatives [5], steroids [6], lignans [7,8], alkanediols [9,10] have been reported. The chalcones in Carthamus tinctorius L. are biologically active compounds, which are reported to have anti-inflammatory, antioxidant, antihepatotoxic, antiviral activities, vasculo-protector and spasmolytic properties [11].…”