‘Erythroblastosis Foetalis’ in the Primate, Tamarinus nigricollis

Gengozian, Nazareth; Lushbaugh, C. C.; Humason, Gretchen L.; Kniseley, Ralph M.

doi:10.1038/209731a0

Cited by 26 publications

(9 citation statements)

References 8 publications

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“…The incidence appears to be higher in offspring of matings between marmoset species, which is comparable to the occurrence of hemolytic disease in mule foals [7]. Experimental production of erythroblastosis in primate animals was first reported in baboons (Papio hamadryas) by Volkova et al [21,22].…”

Section: Experimental Animal Models For Erythroblastosis Fetalismentioning

confidence: 62%

“…Spontaneous hemolytic disease in utero has been reported in marmosets [6,7], the twin chimerism of which renders the situation more complex. The incidence appears to be higher in offspring of matings between marmoset species, which is comparable to the occurrence of hemolytic disease in mule foals [7].…”

Section: Experimental Animal Models For Erythroblastosis Fetalismentioning

confidence: 99%

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Erythroblastosis Models

Wiener¹,

Socha²,

Niemann³

et al. 1975

J Med Primatol

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The current status of erythroblastosis fetalis in man and in animals is briefly reviewed with emphasis on present knowledge of nonhuman primates as models for the disease. Our studies in crab-eating macaques indicate that presence in a mother’s serum of potent antibodies reactive for red cells of her fetus will not necessarily cause erythroblastosis; in one case the maternal antibodies did not penetrate the placental barrier, and in two cases although the fetal red cells were maximally antibody-coated, they remained undamaged and the disease failed to develop.

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Section: Experimental Animal Models For Erythroblastosis Fetalismentioning

confidence: 62%

Section: Experimental Animal Models For Erythroblastosis Fetalismentioning

confidence: 99%

Erythroblastosis Models

Wiener¹,

Socha²,

Niemann³

et al. 1975

J Med Primatol

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“…Congenital malformations of new world primates have been described even less frequently. Reported congenital defects are: defects of the diaphragm in golden lion tamarins [1]; a supernumerary left kidney, thyroid anomalies consistent with the campomelic syndrome in squirrel monkeys [30]; achondroplastic‐like dwarfism, polydactylism and syndactylism in neonatal tamarins [2]; ‘erythroblastosis fetalis’ and syndactylism in Saguinus nigricollis [11, 15]; microphthalmia, ocular hypertelorism, cleft lip and palate and polydactylism, lobster claw abnormality and imperforate vagina in Callithrix jacchus [6, 26, 28].…”

Section: Discussionmentioning

confidence: 99%

Congenitally caused fused labia in the common marmoset (Callithrix jacchus)

Isachenko

Nayudu

Isachenko

et al. 2002

J of Medical Primatology

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In this paper, the occurrence of an external genital abnormality in female marmoset monkeys (fused labia) is discussed. This malformation was detected, for the first time, in a group of animals at the German Primate Center (GPC), Goettingen. The malformed vulva was completely sealed except for an opening of 1.5-2.5 mm around the urethra sufficient for urination. Because of this defect the animals were not able to copulate. As a consequence, the affected females were functionally infertile although they had a normal genital tract and a regular cycle. This vulvar abnormality was found in 12 females, offspring of 10 pairs in which either one or both came to the German Primate Center from two genetically related colonies in Munich, Germany, and one colony in Basel, Switzerland. The abnormality appeared to be recessive and inheritable from either parent. In pairs in which both animals were from one of the mentioned colonies, 45% of the female offspring were affected. In pairs where only one partner came from these colonies, 26% of female offspring had the malformation. These results indicate that avoidance of inbreeding, which is frequently performed in primate colonies, may reduce, but not eliminate the expression of abnormalities of genetic origin. Therefore selective breeding is required, and, in colonies where these recessive mutations are widespread, the development of genetic screening tests would be advantageous.

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“…Their occurrence de scribed here is of prime importance for the use of primate animals as models for man in experimental work involving blood transfusion, cross circulation and transplantation, as well as in breeding or primate ani mals. Recent publications on maternofetal incompatibility observed in primate animals [2,18,20,25] indicate that some of the antibodies ob served may be the result of isoimmunization in pregnancy.…”

Section: Discussionmentioning

confidence: 99%